Facultat de Biologia: Recent submissions
Now showing items 86-105 of 252
Acoustic monitoring: new applications for bird and human wildlife conflicts monitoring
In a context of the global biodiversity crisis, such as the one in which the planet is found, having accurate information linked to biodiversity monitoring systems is essential to be able to make evidence-based decisions. ...
SLIMP: a mitochondrial protein involved in cell cycle regulation
SLIMP (Seryl-tRNA Synthetase-Like Insect Mitochondrial Protein) was identified during the generation of a mitochondrial human disease fly model. SLIMP was described as a previously uncharacterized paralog of the Drosophila ...
Molecular analysis of MTOC assembly - the role of ninein-like protein
Despite decades of work, the molecular requirements underlying microtubule- organizing center (MTOC) formation at the centrosome remain obscure. Progress is hindered by the complexity of this organelle, which is composed ...
Genetic and epigenetic insights into colorectal tumorigenesis
Colorectal cancer (CRC) is a major health burden with large numbers of new cases worldwide and high disease-specific mortality, despite great advances made towards improving patient clinical outcomes. It arises through the ...
Identification and characterization of new complex patterns of structural DNA and RNA alterations in cancer
Human cancer arises as a result of genomic alterations that transform cells and make them to grow without control and to pathological levels. The characterization of such genomic changes has enabled understanding tumor ...
Mechanisms that regulate intracellular DNA entanglement
Topoisomerase II often produces DNA knots and catenates when its DNA strand passage activity equilibrates the topology of intracellular DNA. However, these DNA entanglements are detrimental for the normal development of ...
Estudio de biomarcadores celulares para la implementación de terapias personalizadas en Fibrosis Quística
La Fibrosis Quística (FQ) es una enfermedad autosómica recesiva que ocurre cuando existen variantes patogénicas bialélicas en el gen Cystic Fibrosis Transembrane Regulator (CFTR), y que codifica por una proteína con el ...
Mejora del control biológico por conservación de las plagas que afectan a cultivos hortofrutícolas
Esta tesis se ha enfocado en evaluar el potencial de mejora del control biológico por conservación en huertos frutales y hortícolas en Cataluña, mediante la integración de infraestructuras ecológicas que promuevan y ...
The environmental change in coastal ecosystems during the Late Holocene as recorded in seagrass sedimentary archives
Coastal ecosystems, especially the vegetated areas, are among the most threatened ecosystems in the world, undergoing a fast and constant decline. Their losses are of serious concern due to their elevated production, ...
Genomic analysis of an introduced ascidian and implications for invasiveness
Invasive species constitute a major threat to global biodiversity and cause important economic losses and ecological impacts. In the marine realm, ascidians include several aggressive invasive species, some of which have ...
Eines per a l'estudi del metabolisme i els efectes dels esfingolípids
1. El paper que tenen les ceramidases en diferents malalties humanes va guanyant interès. Tot i així, la recerca en aquest àmbit ha estat obstaculitzada per la manca d’inhibidors i substrats específics per les diferents ...
Secretory markers of dense-core vesicles in Alzheimer's disease
The regulated secretory pathway is a hallmark of professional secretory cells as neurons and endocrine cells. Significant peptidergic neurotransmitters as hormones, neurotrophins and growth factors are targeted to ...
The role of behavioural and feedback mechanisms in mediating herbivory processes in Mediterranean seagrass ecosystems
The role of consumer-resource relationship is the basis of the structure and functioning of ecological communities. The traditional lens for studying such interactions have tended to omit the importance of the species ...
Gene regulatory networks in pancreatic islets and insulinoma
Insulinomas are extremely rare pancreatic neuroendocrine (PNET) tumours that develop from the β-cells of the pancreas.β-cells are the only cells capable of producing the hormine insulin, and play a major role in glucose ...
The metabolic aspects of macroH2A histone variants
The histone variant macroH2A is the only structural chromatin component containing a macrodomain. In vertebrates, two genes and one event of alternative splicing give rise to three macroH2A proteins that differ in their ...
Hydrometeorological and climatic control over lake phytoplankton: the importance of time scales
In the present thesis we focus on the two extremes of the wind speed – storms and atmospheric stilling – and analyse their impacts on lake environments and phytoplankton dynamics over short and long periods. As we realised ...
The role of SIRT1 and SIRT6 in epigenetic regulation of genome stability under stress
The Sirtuin family of NAD+-dependent enzymes plays a key role in the maintenance of genome integrity upon stress. Sirtuins coordinate the response to different forms of stress at different levels and have been involved ...
Integrating agriculture and conservation: The value of fallow land and its management for farmland and steppe bird conservation
Extensive farmland ecosystems are widespread and biodiversity-rich, yet they face important human pressures since the beginning of agriculture intensification, which is leading them into a severe biodiversity crisis. As a ...
Analysis of the contribution of Barrier-to-Autointegration Factor (BAF) to centromere function and mitosis progression
This work is focused on Barrier-to-Autointegration Factor (BAF) protein. BAF is a nuclear envelope (NE) component that binds chromatin and is required for NE reassembly (NER) at mitosis exit. Previous work in our group ...
Comprehensive identification and characterisation of germline structural variation within the Iberian population
One of the central aims of biology and biomedicine has been the characterisation and understanding of genetic variation across humans, to answer important evolutionary questions and to explain phenotypic variability ...
