Facultat de Biologia: Recent submissions
Now showing items 106-125 of 252
Investigating the role of mitochondrial dysfunction in the pathogenesis of Parkinsons´s disease using patient-specific derived astrocytes
Parkinson’s disease (PD) is an incurable, chronically progressive disorder of old age leading to premature invalidity and death. Clinically, PD is characterized by classical motor syndrome linked to a progressive loss of ...
An epigenetic approach to fatty acid metabolism in haematological malignancies
The role of fatty acids to overcome stress and contribute to disease progression is becoming increasingly evident in haematological diseases. Further, epigenetic factors play an important role in the aetiology of myelodysplastic ...
Role of Capicua-L in RTK signaling and endocycle regulation
The HMG-box protein Capicua (Cic) is a conserved transcriptional repressor with key functions downstream of receptor tyrosine kinase (RTK)-Ras-MAPK signaling pathways. In both Drosophila and mammals, Cic is expressed as ...
Setting up stem cell therapy for human retina: from organotypic cultures to cell fusion understanding
Visual impairments and different retinopathies have been silently increasing in the modern society and they become a medical hurdle in need to be addressed. Müller glial cells (MGCs), in lower vertebrates, show regenerative ...
Cambios en la capacidad funcional producidos por la hemodiafiltración "on-line"
Las personas con insuficiencia renal crónica (ERC) suelen manifestar sentirse más fatigados al terminar la sesión de diálisis (HD). Cabe destacar que se trata de una población compuesta por pacientes que pueden presentar ...
Function of the histone demethylase PHF8 in neural progenitor cells and glial differentiation
Taking into consideration the current knowledge about the subjects treated, several goals were proposed for this PhD thesis in order to further understand PHF8 function in both astrocytes and neural stem cells biology. To ...
Proteomic profile in postmortem brain in chronic schizopfrenia
Schizophrenia is a complex psychiatric disorder involving dysregulation of multiple pathways. In the last decades, the cortico-cerebellar-thalamo-cortical circuit has been proposed to play a key role in cognitive impairments ...
Factors implicats a l’estructura de l’heterocromatina constitutiva pericèntrica
La cromatina és una estructura nucleoproteïca dinàmica i jeràrquicament organitzada dins del nucli cel·lular. Segons la seva funcionalitat, la cromatina es pot classificar en dos tipus de regions: l’eucromatina, també ...
Biodiversidad, biogeografía y patrones evolutivos en crustáceos (Anomura, Galatheoidea) de zonas tropicales y templadas
The present dissertation addresses the study of the diversity, systematics, biogeography and evolutionary history of squat lobster superfamily Galatheoidea, founded on integrative taxonomy criteria. Squat lobsters are a ...
In silico design of antibodies for biomedical applications
Proteins are large macromolecules constituted by amino acids that are responsible for most of the biological processes within a cell. Proteins showing high complementary affinity may bind forming protein-protein complexes. ...
Patterns of activity in marine planktonic copepods: diel rhythms and driving factors
Marine planktonic copepods play a key ecological role in pelagic food webs. The study of their patterns of activity is fundamental in order to better understand the processes involved in the transfer of energy from lower ...
Functional interplay between ER and MAF transcription factors in breast cancer bone metastasis
Metastatic breast cancer (BCa) is the leading cause of death in BCa patients. Current therapies for BCa aim at cell proliferation and, therefore, latent disseminated cells are able to escape treatment. For this reason, ...
Modeling neurofibromatosis type1 neurofibroma composition and formation
Neurofibromatosis type 1 (NF1) is a genetic disease caused by inherited mutations in the NF1 gene. NF1 is a cancer predisposition syndrome, and the disease’s hallmark is the appearance of tumors of the peripheral nervous ...
Evaluación de la vulnerabilidad y del estado de conservación de ecosistemas marinos bentónicos especialmente productivos del Mediterráneo frente al impacto de la pesca de arrastre, para impulsar su correcta gestión
En el mar Mediterráneo existen hábitats especialmente productivos como los fondos de maërl y de agregación de crinoideos, que son explotados en la actualidad por la flota de arrastre. Esta actividad supone un impacto que ...
Study of complex chromosomal rearrangements in cancer. The role of extrachromosomal circular DNA as a genome remodeler in neuroblastoma
This thesis illustrates the work I have developed as a Ph.D. student in the computational genomics group lead by Dr. David Torrents at the Barcelona Supercomputing Center. The group’s expertise in the analysis of biological ...
Deciphering the molecular and phenotypic effects of a Drosophila melanogaster transposable element located in a unique insertional cluster
Understanding how organisms adapt to their environment remains an open question in Biology. So far, most projects focus on the study of single nucleotide polymorphism variants, while other types of mutations, likely to ...
Environmental effects during gonadal development in fish: role of epigenetics
In many organisms, sex is determined by a combination of genetic and environmental influences. Epigenetic regulatory mechanisms such as DNA methylation integrate both types of influences. However, understanding how genetic ...
Molecular mechanisms for active DNA demethylation in cellular immune models
Epigenetic factors, such as histone post-translational modifications and DNA methylation, are critical determinants of gene expression, which ultimately defines cell identity and function. Despite intense research in DNA ...
Alternative splicing control over naïve and primed pluripotency
A fundamental step in embryo development is the transition through pluripotency. There are two known sequential states of pluripotency termed naïve and primed pluripotency. Considerable efforts have been made to characterize ...
Papel del Polietilenglicol 35 en la Modulación de los Procesos Inflamatorios Asociados al Páncreas
A pesar de las extensas investigaciones durante las últimas décadas, la pancreatitis aguda (PA) continúa siendo un reto para el manejo clínico, con una importante carga de morbilidad, mortalidad y coste, cuando la enfermedad ...
