Facultat de Biologia: Recent submissions
Now showing items 66-85 of 252
Molecular characterization of High Risk Neuroblastoma. Potential biomarkers for high-risk neuroblastoma classification
[eng] BACKGROUND: High-risk neuroblastoma (NB) represents a heterogeneous group of tumors, whereby patients can display response to treatment and long-term outcome or develop early progressive, chemoresistant disease with ...
Network-driven strategies to integrate and exploit biomedical data
[eng] In the quest for understanding complex biological systems, the scientific community has been delving into protein, chemical and disease biology, populating biomedical databases with a wealth of data and knowledge. ...
Application of Next Generation Sequencing to Study the Genetics of Idiopathic Neonatal Arterial Ischemic Stroke
[eng] Neonatal arterial ischemic stroke (NAIS) is a cerebrovascular disease that shows a focal disruption of cerebral blood flow due to artery obstruction. Due to its early onset, it can cause long-lasting outcomes such ...
Biodiversity assessment of marine benthic communities with COI metabarcoding: methods and applications
[eng] Ecosystem biomonitoring is crucial for proper management of natural communities during the Anthropocene era. With the advent of new sequencing technologies, DNA metabarcoding has been proposed as a game-changing tool ...
Pharmaceutical development of nanosystems for the delivery of drugs in epidermis and hair follicles, skin biodistribution studies
[eng] Different transdermal drug delivery platforms have been developed for epidermal and follicular targeting. Nanoformulations have been developed, optimised and physicochemically characterised with complementary techniques. ...
Protective role of polyethylene glycol 35 against hepatic cold and warm ischemia
Steatotic livers are considerably more prone to IRI, in which turn, it is known to impair mitochondrial function. Our working hypothesis lies on the fact that impaired mitochondrial function and reduced protection against ...
Development and application of computer-aided strategies for virtual screening and hit-to-lead
The incremental application of supercomputers to offer solutions to complex problems has motivated the usage of computational modeling tools in drug design pipelines. Specifically, small low-affinity compounds are modified ...
Characterization of the molecular mechanisms used by JmjC-lysine demethylases to regulate gene expression
The thesis objectives resulted from previous work from Dr Martínez-Balbás lab that characterized the cooperation between TGFβ and JMJD3 to regulate transcription at enhancers, promoters, and gene bodies.Taking into ...
Modeling and targeting metastatic relapse in colorectal cancer
Colorectal cancer (CRC) kills around 700,000 people worldwide every year. The majority of these deaths are the result of dissemination of the disease to foreign organs. Despite undergoing curative resection of the primary ...
Understanding stochastic and deterministric microbial assembly processes in ephemeral saline lakes
Understanding the mechanisms and processes driving biological com- munities assembly, i.e. determining why a specific community is found under certain circumstances, is one of the fundamental questions in ecology. The ...
Fibroblastic SNAIL1 induces a metastasis-permisive tumor stroma by regulating fibronectin alternative splicing
SNAIL1 is a transcription factor with roles in repression of epithelial genes and enhancement of mesenchymal genes. As such, it plays a key role in Epithelial-to-mesenchymal transition and in fibroblast activation into ...
Refining prognosis capacity and implementing priciples of personalized therapies for Neurofibromatosis Type 2
Neurofibromatosis type 2 (NF2) is an autosomal dominant condition caused by loss of function variants in the NF2 gene. The pathognomonic feature of the disease is the development of bilateral vestibular schwannomas (VS), ...
Estudi d'alguns aspectes del metabolisme dels aminoàcids en la rata després del part
Se han estudiado los niveles de aminoácidos individuales (lactato, glucosa, glicerol, etc.) en plasma y actividad de GLU-deshidrogenasa, ASP-transaminasa, ALA-transaminasa, TYR-transaminasa, GLN-sintetasa, SER-deshidratasa, ...
Caracterització de les activitats triacilglicerol ester hidrolases en miòcits aïllats de cor de rata
En células aisladas de corazón de rata se caracterizaron las actividades triacilglicerol ester hidrolasas. Se detecta la presencia de actividad acida localizada en el interior de los lisosomas, que no es sensible ni a la ...
Liquid-liquid phase separation in gene regulation and disease
Intrinsically disordered (ID) proteins or regions are protein sequences that lack stable secondary and tertiary structures. ID proteins are particularly prone to undergo liquid- liquid phase separation (LLPS). The structures ...
Three-dimensional organization of HP1c-complex target genes
It has been previously shown that the Drosophila heterochromatin protein 1c (HP1c) forms a complex with the transcription factors (TF) WOC and ROW, and the extraproteasomal ubiquitin receptor dDsk2. The HP1c-complex localizes ...
Post-transcriptional control of anti-tumor immune responses
Translation of mRNAs into proteins is a highly regulated step of gene expression. In cancer, post-transcriptional and translational control have a critical effect on transformation, controlling proliferation, survival, ...
Investigating genetic and mechanistic interactors in familial cardoimyopathy through advanced disease modeling
Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac disease and a frequent cause of heart failure and sudden cardiac death. HCM is a highly complex condition defined by clinical and genetic heterogeneity. ...
Cell-extrinsic barriers of cellular plasticity: contribution of natural killer cells, T lymphocytes and vitamin B12 to in vivo reprogramming
The ectopic expression of transcription factors Oct4, Sox2, Klf4 and Myc (OSKM) enables the conversion of differentiated cells into pluripotent stem cells, a process known as “reprogramming”. Methods based on in vivo ...
Unravelling genetic predisposition to familial breast and ovarian cancer: new susceptibility genes and variant interpretation by in silico approaches
Patients with hereditary breast and ovarian cancer (HBOC) in whom a causative pathogenic variant is not identified after genetic analysis may not benefit from prevention, early detection, or precision treatment measures. ...
