Universitat de Barcelona
Now showing items 9563-9582 of 11082
Voltage gated potassium channels (Kv) play important roles in different biological process such as generation and propagation of the nerve pulse and the cardiac action potential, promotion of insulin secretion, cell volume ...
[eng] DYRK1A is a kinase that is expressed in virtually all tissues and cell types and is implicated in human diseases. Several studies indicate that DYRK1A is a dose-dependent gene with a prevalent function in brain ...
The identification of genes that mediate metastasis is pivotal to better understand the mechanism, to develop novel drugs and to stratify patients with highest risk and consecutively administrate them preventive treatments. ...
1. General Overview MTAP is a key enzyme in the methionine salvage pathway and controls the levels of methylthioadenosine (MTA). Lost of MTAP, which is frequent in melanoma, results in higher intra and extracellular MTA ...
Mitochondria are well known for their role as bioenergetic and biosynthetic organelles. Recently, they also have emerged as one of the main regulators of innate immune responses, mostly for its ability to modulate several ...
The γ-‐tubulin ring complex (γTuRC) is required to efficiently generate new microtubules (MT) in a process known as MT nucleation. In mitotic cells, MT nucleation by γTuRC occurs from the centrosome, in vicinity of the ...
The process that gives rise to all the mature blood cells from the HSCs (Hematopoietic Stem Cells) is known as hematopoiesis. In the adult, hematopoiesis takes place in the bone marrow although the HSCs are likely generated ...
In normal epithelial cells, p38α has a well-established role as a tumor suppressor. However, recent reports have illustrated pro-tumorigenic functions for the p38α pathway by promoting tumor cell survival and proliferation. ...
[eng] The lungs are constantly exposed to external particles and microbes, so their particular immune environment is immunosuppressive to avoid unnecessary inflammatory responses. This increases the susceptibility of this ...
Tumors evolve by sequentially acquiring genetic abnormalities, like K-Ras activation and Tp53 loss of function, which enable transformed cells to survive, proliferate, invade, and reprogram their microenvironment. ...
Nowadays entrepreneurs deal with new technological, social and environmental challenges. Faced with this unpredictable environment, personal values can help to understand the decisions that have to be made. Personal values ...
Diacylglycerol (DAG) is required for the generation of transport carriers at the Golgi complex. Several enzymatic reactions have been found to contribute to the maintenance of DAG levels at this organelle. However, the ...
Pericytes (PCs) are important regulators of the vascular development promoting vessel growth and stabilization. They have recently emerged as a therapeutic target to promote or inhibit angiogenesis. Therefore, advancing ...
Reelin is a high molecular weight extracellular glycoprotein that exhibits key roles both in the development of the central nervous system and in adult synaptic plasticity. Reelin expression during brain development ...
It is difficult to imagine life without changes influenced by technology and innovation, which are characteristic of the era in which we live, with changes that, albeit always present throughout the history of mankind, are ...
Inflammatory bowel diseases (IBD) are chronic inflammatory processes that affect the gastrointestinal tract. IBD is characterized by an intestinal inflammation and epithelial cell injury leading to a poor psychosocial ...
Chromatin compaction is regulated by different factors, among them histone posttranslational modifications. There are different histone modifications, and among them, acetylation and methylation of lysine residues. Acetylation ...
Hoy en día es difícil imaginar nuestra vida sin las Tecnologías de la Información (TI), de hecho, las Tecnologías de Información y Comunicación (TIC) juegan un papel muy importante en casi todas las organizaciones públicas ...
Biological diversity in a global scale has been threaten seriously by anthropogenic disturbances in ecosystems. Changes in land cover and land use affect biodiversity, causing habitat loss and species extinction, or ...
EN CATALÀ DE LA TESI DOCTORAL<br/><br/>"Importància de l'adhesió al substrat en la mecànica cel·lular: Implicacions en neutròfils i cèl·lules endotelials microvasculars".<br/><br/>En organismes multicel·lulars complexos ...
