Mostrando ítems 96-115 de 116
Sousa, Nidia de (Fecha de defensa: 2017-07-17)
A successful cell renewal, which occurs throughout the life of an organism, relies on multiple events, including proliferation and differentiation of progenitor cell populations, and death of unnecessary cells. Out of the ...
Pappa, Stella (Fecha de defensa: 2019-04-10)
During neural development, signaling molecules and networks of expressed transcription factors cooperate to control cellular fate. Chromatin acting factors are essential players in cell proliferation and differentiation ...
Gheitasi, Hoda (Fecha de defensa: 2024-01-26)
[eng] Sjögren Syndrome is a systemic autoimmune disease that affects the exocrine glands, most notably the salivary and lacrimal glands, although it can affect other mucosal surfaces. Inflammation at these sites leads to ...
Pi Roig, Aina (Fecha de defensa: 2018-04-06)
Tbx5 is a transcription factor expressed in the developing eyes, heart and upper limbs. Mutations in human TBX5 cause Holt-Oram syndrome (HOS), a condition characterised by heart and upper limb malformations. In zebrafish, ...
Martínez-Gil, Núria (Fecha de defensa: 2021-03-12)
Osteoporosis is a complex disease characterized by low bone mass, microarchitectural deterioration, and increased fracture risk. It is the most common bone disease that affects more than 200 million people worldwide and ...
Barbanti, Anna (Fecha de defensa: 2021-09-23)
Conservation actions aim to preserve and recover animal and plant species using in-situ or ex- situ strategies. The first, aims to protect and sustain populations in their natural habitat, the second are implemented when ...
Murcia Rosero, Lada (Fecha de defensa: 2019-10-28)
Most human solid tumors present signs of genomic instability. Activated oncogenes have been proposed to induce genomic instability through the generation of replicative stress. In this thesis, we have sown that the expression ...
Martínez Puchol, Sandra (Fecha de defensa: 2021-02-18)
L’objectiu principal de la present tesi doctoral ha estat l’optimització i aplicació de procediments basats en la seqüenciació massiva per a la descripció del viroma associat a l’aigua residual i a altres mostres d’interès ...
Castellarnau Serra, Montserrat de (Fecha de defensa: 2018-09-20)
El virus de l’hepatitis A (HAV), el prototip del gènere Hepatovirus, té una sèrie de característiques que el diferencien de la resta de membres de la família Picornaviridae. Entre aquestes, la via de sortida descrita ...
Castellano Escuder, Pol (Fecha de defensa: 2021-09-08)
This thesis is the product of three and a half years working on the complex world of metabolomics and nutrition. All the work presented here is focussed on the problems arising from associating and integrating ...
Garcia Gerique, Laura (Fecha de defensa: 2020-12-23)
Neuroblastoma (NB) is the most common extracraneal solid tumor diagnosed in the first 5 years of childhood and accounts for approximately 15% of all pediatric cancer-related deaths. At the time of diagnosis, about half of ...
Pascual Alonso, Ainhoa (Fecha de defensa: 2023-07-14)
[eng] MECP2 is a multifunctional gene involved in multiple processes such as transcription regulation, chromatin remodelling, splicing and miRNA regulation. Malfunction of MECP2 due to loss of function mutations leads to ...
Aguirre Gómez, Josu (Fecha de defensa: 2020-07-14)
The translation of Next Generation Sequencing (NGS) technologies from the research field to the clinical setting and, specifically, the results obtained in terms of diagnostic yield remain far from expected. This situation ...
Abad Morales, Víctor (Fecha de defensa: 2017-02-03)
La sumoïlació és una modificació posttraduccional (PTM) que consisteix en la conjugació covalent i reversible d’una proteïna SUMO (Small ubiquitin-like modifier) al residu lisina d’una proteïna diana. Igual que la ubiquitina, ...
Badia Ramentol, Jordi (Fecha de defensa: 2020-01-14)
Colorectal cancer (CRC) is the second-highest cause for cancer-related mortality worldwide. Patients suffering from CRC generally don’t die from primary tumours but rather from metastasis, for which there are no effective ...
Abzazou Souisa, Tarik (Fecha de defensa: 2016-12-21)
La presente tesis titulada Técnicas moleculares para la caracterización microbiológica de los procesos de eliminación de nutrientes en las EDARs, se ha desarrollado desde dos puntos de vista, el primero fue la puesta a ...
Navas Pérez, Enrique (Fecha de defensa: 2017-07-28)
Uno de los mecanismos genéticos que facilitan la innovación evolutiva es la formación de nuevos genes. De entre los procesos que permiten generar nuevos genes, la domesticación molecular de genes transposónicos es uno de ...
Benítez Álvarez, Lisandra (Fecha de defensa: 2022-06-16)
Evolutionary Biology offers a set of methods and theories to elucidate the evolutionary processes that lead to the diversification of life. With the development of sequencing technologies, the access to genetic data has ...
Leria Florensa, Laia (Fecha de defensa: 2019-10-28)
The main goal of the present thesis has been to shed light into the processes that shape the genetic diversity of organisms, focussing in the following factors: the type of reproduction, the morphological diversity of ...
Martín Díaz, Julia (Fecha de defensa: 2017-09-08)
La presente investigación explora la utilidad de los bacteriófagos y otros microorganismos indicadores de la contaminación fecal en relación a dos grandes tipos de sólidos relevantes en el ciclo del agua, los lodos de ...