Recent Submissions

Quorum Sensing as a Potential Biomarker Target to Diagnose Staphylococcus aureus Infections 

Ferrero Ruedas, Carla (Date of defense: 2025-04-25)

[eng] Staphylococcus aureus is a Gram-positive bacterium capable of causing a wide range of infections, from minor skin conditions to severe diseases like pneumonia and sepsis. Its adaptability, virulence factors, and the ...

Estudio clínico para identificar especies lipídicas y proteínas moduladas en obesidad infantil: nuevas claves en la influencia del estilo de vida 

Soria Gondek, Andrea (Date of defense: 2025-04-04)

[spa] INTRODUCCIÓN: La obesidad es un trastorno metabólico caracterizado por una acumulación anómala de grasa, desencadenando lipotoxicidad, inflamación crónica y enfermedades asociadas. La biología de la obesidad pediátrica ...

Desenvolupament de sistemes nanobiotecnològics multifuncionals per a l'administració de Riluzol en malalties neurodegeneratives 

Esteruelas Navarro, Gerard (Date of defense: 2025-03-13)

[cat] La present tesi doctoral aborda el desenvolupament i l’avaluació de noves eines multifuncionals basades en NPs polimèriques (NPs) com a estratègia avançada per a l’administració i l’optimització terapèutica del Riluzol ...

Desarrollo de Nanopartículas Lipídicas para vehiculizar siRNA a través de la Barrera Hematoencefálica 

Vargas Monge, Ronny (Date of defense: 2025-01-08)

[spa] La administración de medicamentos hacia el sistema nervioso central (SNC) es uno de los principales retos en la neurofarmacología, principalmente debido a la presencia de la barrera hematoencefálica (BHE). Aunque ...

A single-cell RNA sequencing approach to understand the mechanisms underlying response and resistance to tofacitinib in ulcerative colitis 

Melón Ardanaz, Elisa (Date of defense: 2025-01-17)

[eng] Ulcerative colitis (UC) is a chronic inflammatory bowel disease that represents a major health problem worldwide due to its increasing prevalence and the lack of effective treatments. Tofacitinib is a JAK inhibitor ...

Atmospheric characterization and time-series analysis of the impact of environmental factors on disease onset 

Fontal Navarrete, Alejandro (Date of defense: 2025-01-16)

[eng] This thesis investigates the complex interplay between atmospheric characterization, environmental factors, and the onset of diseases, specifically focusing on Kawasaki Disease (KD) and COVID-19. Through time-series ...

Epigenetic determinants of differentiation in monocyte subsets: implications in autoimmune disease 

Ferreté Bonastre, Anna Guiomar (Date of defense: 2025-04-09)

[eng] Monocytes are an extremely plastic and heterogeneous cell type with fundamental roles in the innate immune system. Single-cell omic studies have revealed a broad range of unique phenotypes and behaviors in the cells ...

Estudio de nuevas aproximaciones terapéuticas aplicadas a patologías musculoesqueléticas en nuevos modelos animales que imitan la patología humana 

Vidal i Fornells, Laura (Date of defense: 2024-12-03)

[spa] Las lesiones musculoesqueléticas afectan a músculos, huesos, articulaciones y tejidos asociados como tendones y ligamentos, causando dolor y reducción de la movilidad, lo que limita la vida social y genera un coste ...

Finding new drugs for CNS diseases by targeting proteases: the case of matrix metalloproteinase-9 and prolyl oligopeptidase 

Trallero Canela, Nuria (Date of defense: 2024-07-19)

[eng] Central nervous system (CNS) diseases are a broad category of conditions limiting health and the ability to function that affects nearly one in six people of the world’s population. Proteases are involved in a large ...

La disfàgia orofaríngia a la malaltia de la neurona motora. Prevalença, diagnòstic i dietoteràpia 

Romero Gangonells, Elisabet (Date of defense: 2024-09-02)

[cat] Introducció: la malaltia de la neurona motora (MND) cursa amb debilitat progressiva de la musculatura i acaba conduint a la mort del pacient en 3-5 anys. La supervivència augmenta fins a 10 anys en alguns fenotips. ...

Advancing antileishmanial treatments through innovative nanotechnology in vitro approaches and characterization of novel therapeutic compounds 

Román Álamo, Lucía (Date of defense: 2024-09-12)

[eng] Leishmaniasis is a vector-borne disease, caused by the parasite Leishmania spp. and transmitted by sand flies of the genus Phlebotomus or Lutzomyia. There are over 12 million people infected worldwide and around one ...

Development of a novel CPT1 enzymatic assay for drug screening. Synthesis and evaluation of UB006 derivatives and flavonoids’ effect on lipid 

Reina i Aibar, Marc (Date of defense: 2024-11-22)

[eng] Lipid metabolism (biosynthesis, storage, and mobilization of lipids within an organism) is a very important aspect of energy homeostasis and plays an essential. Obesity is a complex multifactorial disease characterized ...

Design and Evaluation of Enzyme-Powered Nanobots for Crossing Biological Barriers and Treating Cancer 

Serra i Casablancas, Meritxell (Date of defense: 2024-11-04)

[eng] The field of nanomedicine has garnered increasing clinical interest over the past few decades, leading to the approval of numerous products, particularly in oncology. This is due to their ability to encapsulate and ...

Protección de hígados patológicos frente a la lesión y al fallo en la regeneración asociado a la cirugía hepática 

Rojano Alfonso, Carlos (Date of defense: 2024-11-08)

[spa] El hígado es un órgano vital para el organismo por la multitud de funciones que desarrolla. Cuando se compromete su actividad, puede ser necesario recurrir a una cirugía mayor hepática. La resección hepática, asociada ...

Investigating abdominal aortic aneurysm mechanisms: searching for new therapeutic targets to restrain inflammation and vascular remodelling 

Puertas Umbert, Lídia (Date of defense: 2024-06-21)

[eng] Abdominal aortic aneurysm (AAA) is a prevalent vascular degenerative disease defined as a focal and permanent dilation of the aorta at the abdominal level. The progressive weakening of the aortic wall can ultimately ...

Pegilación y liofilización de nanopartículas sólidas lipídicas con colesteril oleato como vectores de ácidos nucleicos 

Narváez Narváez, David Andrés (Date of defense: 2024-05-29)

[spa] Las nanopartículas catiónicas sólidas lipídicas (cSLN) han surgido como una herramienta prometedora en terapias genéticas y de ARN. Esta investigación se enfocó en mejorar la formulación existente de SLNs con colesteril ...

Mecanismos de señalización en el trasplante hepático de donantes con criterio extendido 

Micó Carnero, Marc (Date of defense: 2024-11-22)

[spa] En la práctica clínica, el trasplante de hígado supone una de las pocas soluciones a enfermedades hepáticas en estado terminal. Multitud de personas fallecen esperando un injerto hepático debido a la escasez de ...

Role of conjugated sterols homeostasis in plant development and stress response 

Lopez Tubau, Joan Manel (Date of defense: 2024-12-19)

[eng] Phytosterols are a family of triterpenoid compounds that occur in free form (FS) or conjugated as steryl esters (SE), steryl glycosides (SG) and acylated steryl glycosides (ASG). Free sterols and their glycosylated ...

Role of HIVEP2 in drug-tolerant persister cancer cells and tumor recurrence 

Mur Espinosa, Alex (Date of defense: 2024-12-17)

[eng] Colorectal cancer (CRC) is a leading cause of death worldwide and tumor recurrence is a frequent complication that arises from minimal residual disease (MRD). Patients can relapse months or even years after an apparent ...

CPEB4 regulation of vasculogenic mimicry in liver cancer: mechanisms and therapeutic implications 

Iralde Cárdenas, Beatriz (Date of defense: 2024-12-12)

[eng] BACKGROUND: Hepatocellular carcinoma (HCC) poses a significant clinical challenge due to its complex vascular abnormalities and the regulatory mechanisms underlying tumor progression. Vasculogenic mimicry (VM), a ...