Recent Submissions

Unraveling the neuro-immunological implications of the Ikaros family in schizophrenia and neuroinflammation 

Ballasch, Iván (Date of defense: 2025-05-06)

[eng] The Ikaros family of transcription factors has been largely described in the context of immune system function and immune system cells development. In the last years, some of its members were found in neural cells, ...

Characterization of striatal development in Huntington’s Disease and its implication to the adult phenotype 

Vila Torondel, Cristina (Date of defense: 2023-09-15)

[eng] Huntington's disease (HD) is a devastating neurodegenerative disorder that manifest itself through motor, cognitive and behavioral symptoms. HD is a monogenic disease caused by CAG expansion in the huntingtin gene, ...

Role of VPS13A in corticostriatal synaptic transmission in a model of Chorea-Acanthocytosis 

García García, Esther (Date of defense: 2023-07-25)

[spa] El objetivo principal de esta tesis ha consistido en analizar el papel de VPS13A en la plasticidad sináptica y el comportamineto corticostriatal en un modelo murino de corea-acantocitosis. En primer lugar hemos ...

Unravelling the contribution of small non-coding RNAs to Huntington’s disease pathogenesis 

Guisado Corcoll, Anna (Date of defense: 2023-07-21)

[eng] BACKGROUND AND OBJECTIVES: Huntington's disease (HD) is an autosomal dominant neurodegenerative disease caused by an abnormal expansion in the number of CAG triplets located at exon 1 of the huntingtin gene (HTT), ...

Insights in the pathogenesis of the aortic aneurysm in Marfan syndrome and new therapeutic approaches 

Rodriguez Rovira, Isaac (Date of defense: 2023-07-20)

[eng] The objective of this thesis was to investigate the effect of a potent inhibitor peptide (P144) targeting transforming growth factor β (TGFβ) on the development of aortic aneurysms in a mouse model of Marfan syndrome. ...

Inmunoterapia del cáncer colorrectal mediante la combinación de fármacos bloqueantes de la vía PD-1/PD-L1 y vacunas de células dendríticas autólogas 

Español Rego, Marta (Date of defense: 2023-07-20)

[spa] En esta tesis se estudia el cáncer colorrectal metastásico y posibles alternativas de tratamiento. Se plantea una terapia combinada con células dendríticas autólogas e inhibidores de la vía PD-1/PD-L1 y se profundiza ...

Role of MITF in IgE and MRGPRX2-dependent mast cell activation 

Guo, Yanru (Date of defense: 2023-07-20)

èng] Anaphylaxis is a severe allergic reaction triggered by allergens to certain foods, medicines, insect venom, and other substances. Anaphylactic shock can be fatal if not treated. Mast cells are the effector cells in ...

Uncovering new therapeutic strategies for motor and cognitive deficits in Huntington's Disease 

Espina Cortes, Marc (Date of defense: 2023-06-23)

[eng] The present thesis focuses on studying possible new therapeutic strategies for the treatment of cognitive and motor symptoms associated with Huntington's disease (HD). More specifically, the first work focuses on ...

The role of 4E-BP1 in Huntington’s disease: modulation of translation initiation as a therapeutic strategy 

Castany Pladevall, Carla (Date of defense: 2023-06-21)

[eng] Precise regulation of translation initiation plays a critical role in learning and memory processes, and defects in this process have been linked to numerous cognitive disorders including neurological disorders such ...

Network alterations in Huntington’s disease beyond the classical model of basal ganglia circuitry 

Conde Berriozabal, Sara (Date of defense: 2023-06-09)

[eng] The main objective of this doctoral thesis has been to elucidate the alterations in the dynamics of neural networks in Huntington's disease (HD) beyond the basal ganglia circuit in order to define new therapies based ...

Clasificación automática de malaria e inclusiones eritrocitarias anómalas en sangre periférica utilizando modelos de machine learning 

Molina Borrás, Angel (Date of defense: 2025-03-03)

[spa] Los especialistas de laboratorio juegan un papel esencial en el diagnóstico del paludismo mediante la identificación de características morfológicas cualitativas de los hematíes en la revisión del frotis de sangre ...

Muscle dysfunction and exercised-based rehabilitation in cardiac diseases: From muscular physiology in animals to prognosis impact on patients 

Cabrera-Aguilera, Ignacio Alfredo (Date of defense: 2023-01-24)

[eng] Cardiovascular diseases (CVD) such heart failure (HF) or acute coronary syndrome (ACS) impairs muscular dysfunction that affect cardiorespiratory fitness. Animals models realistically mimicking CVD, including the ...

Depletion of aneuploid cells in epithelial tissues is shaped by cell-to-cell interactions 

Fusari, Elena (Date of defense: 2025-04-04)

[eng] Aneuploidy, the major cause of miscarriages, is pervasive in early human embryos, and later in life, it correlates with pathological conditions including cancer and other ageing-related conditions. At the cellular ...

Implications of astrocytic RTP801 in neuroinflammation and neurodegeneration in Alzheimer’s disease 

Chicote González, Almudena (Date of defense: 2024-11-29)

[eng] The central nervous system (CNS), consisting of the brain and spinal cord, is supported by various cells including neurons, glial cells, and blood vessel cells. Neurons are responsible for transmitting signals, while ...

Exploring extracellular small RNAs as potential early biomarkers and mediators in the pathogenesis of Huntington’s disease 

Herrero Lorenzo, Marina (Date of defense: 2024-10-18)

[eng] Huntington's disease (HD) is a dominantly inherited neurodegenerative disorder caused by an expansion of CAG triplets in the huntingtin gene (HTT). The main neuropathological signs of HD include the presence of ...

Investigating therapeutic targeting to intercellular adhesion molecule 1 through epitope, isoform, and cross-reactivity selection 

Vigo, Marco (Date of defense: 2024-09-26)

[eng] AIM AND HYPOTHESIS: Based on the previous literature and indicated gaps of knowledge, the hypothesis for this study was that by generating cell lines expressing only specific forms of ICAM-1, it may be possible to ...

Nous abordatges en l'estudi de les malalties autoimmunitàries 

Pérez Isidro, Albert (Date of defense: 2024-10-30)

[cat] HIPÒTESIS: Un augment del nombre de biomarcadors disponibles amplia la informació a l’abast del clínic i ajuda a una millor la presa de decisions mèdiques i terapèutiques per a l’atenció dels pacients amb malalties ...

RTP801: a novel regulator of the tRNA ligase complex in Alzheimer's disease 

Campoy Campos, Genís (Date of defense: 2024-06-19)

[eng] RTP801/REDD1 is a stress-responsive protein overexpressed in neurodegenerative diseases such as Alzheimer’s disease (AD) that contributes to cognitive deficits and neuroinflammation. Here we found that RTP801 interacts ...

Inhibition of KRAS oncogenic activity by interfering with new KRAS interactors 

Abuasaker, Baraa (Date of defense: 2024-06-14)

[eng] INTRODUCTION: The Kirsten rat sarcoma oncogene (KRAS) homologue stands out as a prominent oncogene, distinguished by its notably elevated mutation rate compared to other oncogenes. This genetic anomaly is intricately ...

Machine Learning for predicting Immunotherapy response from routine Medical Imaging 

Ligero Hernández, Marta (Date of defense: 2024-03-15)

[eng] HYPOTHESIS: Precision oncology has revolutionized the landscape of cancer treatment. Emerging therapeu- tic approaches, such as immunotherapy or anti-angiogenic agents, have exhibited remarkable outcomes in solid ...