Kennington, Stuart (Date of defense: 2020-12-21)
This thesis focuses on the search for new methodologies for the direct, stereoselective and catalytic formation of carbon-carbon bonds through the formation of chiral nickel(II) enolate species and the ...
Brun Cubero, Omar (Date of defense: 2016-07-27)
An alternative allowing diene-derivatised polyamides to be used in Diels-Alder conjugation reactions has been explored and developed. In this methodology, conjugation takes place between a fully protected, ...
Lobo Ruiz, Ariadna (Date of defense: 2019-05-10)
Peptides and proteins are essential substances for living organisms, as they can be found in every cell and tissue and are involved in many biological and physiological processes. Given their intrinsic ...
Mir Morro, Bartomeu (Date of defense: 2019-11-22)
Given the increasing interest in i-motif structures, obtaining such structures as well as detailed structural information under physiological conditions have become hot topics in the structural biology ...
Agramunt Pi, Jordi (Date of defense: 2019-11-08)
2,2-Disubstituted cyclopent-4-ene-1,3-diones (CPDs), which have been as non-hydrolysable maleimide analogs, have been found to possess an unexpected reactivity with N-terminal cysteines. Whilst maleimides ...
Bujaldón Carbó, Roger (Date of defense: 2022-11-22)
[eng] The increasing demand on next-generation displays encourages an exhaustive research on the development of new and enhanced semiconductors. Apart from the conventional inorganic materials, organic-based ...
Bonelli Blasco, Joaquin Daniel (Date of defense: 2022-12-14)
[eng] Nanomedicine is one of the cutting-edge fields in most of medical applications, specially, in oncology. The possibility to selectively vehiculize and specifically release a wide range of anticancer ...
Rojo Solé, Josep Maria (Date of defense: 2022-11-02)
[eng] P-Stereogenic ligands have demonstrated to be highly efficient for asymmetric catalysis, especially in metal-catalyzed asymmetric hydrogenation reactions. Among them, those bearing bulky substituents ...
Rovira Vidal, Anna (Date of defense: 2023-03-03)
[eng] In this Thesis, we have explored the applications in cancer diagnosis and therapy of COUPY fluorophores, a new family of compounds based on the coumarin structure and operating in the far-red to ...
Lázaro Palacios, Ariadna (Date of defense: 2023-05-05)
[eng] This Doctoral Thesis is focused on the synthesis of cyclometallated platinum compounds with different structural modifications rationally designed specifically for biological or optical applications. ...