Now showing items 117-136 of 229

    Identification of suppressors of the constitutive photomorphogenic phenotype of pifq: from chloroplasts to rhythmic growth 

    Martín Matas, Guiomar (Date of defense: 2015-11-27)

    Plants germinated in the dark under the soil surface, undergo skotomorphogenic development. Once they emerge from the soil surface perceive light for the first time. Then, seedlings switch from skotomorphogenic to ...

    Impacts of climate and drought on tree radial growth in Neotropical dry forests: Scaling up from short to long time-scales = Impactos del clima y las sequías en el crecimiento radial de los árboles en los bosques secos Neotropicales: Evaluación de sus efectos a diferentes escalas temporales 

    Chaparro Mendivelso, Hooz Angela (Date of defense: 2016-12-13)

    This thesis analyzed the dynamics of tree radial growth at different time-scales in relation to climate and drought in two tropical dry forests (TDFs) from Colombia (Tuluá) and Bolivia (INPA). The specific objectives were: ...

    Implementació i desenvolupament d'estudis funcionals per demostrar la patogenicitat de variants de significat incert i identificar nous gens causants de malaltia 

    Muñoz Pujol, Gerard (Date of defense: 2023-11-23)

    [cat] Les malalties metabòliques hereditàries (MMH) són un grup de patologies amb una gran heterogeneïtat clínica, bioquímica i genètica. Actualment se n’han descrit més de 1 800. En l’última dècada la implementació de ...

    Implementation of a novel analytical framework for large-scale genetic data. Extending the genetic architecture of type 2 diabetes beyond common variants 

    Bonàs Guarch, Sílvia (Date of defense: 2017-01-13)

    The major landmark in modern genomic and biological research has been the first survey of the entire human genome. On June 2000 the staging of Bill Clinton along with Craig Venter and Francis Collins extolled how genome ...

    Improving the description of protein-protein association energy 

    Romero Durana, Miguel Alfonso (Date of defense: 2018-11-26)

    Proteins play a crucial role in virtually every biological process taking place within our cells. Most of the times, proteins do not participate in these processes alone but forming complexes of two or more proteins. ...

    In silico design of antibodies for biomedical applications 

    Amengual-Rigo, Pep (Date of defense: 2021-02-15)

    Proteins are large macromolecules constituted by amino acids that are responsible for most of the biological processes within a cell. Proteins showing high complementary affinity may bind forming protein-protein complexes. ...

    Influence of predictable anthropogenic food subsides on seabird´s breeding investment 

    Real Garcia, Enric (Date of defense: 2019-12-12)

    Recent policies on the ban of fishing discards and the closure of open-air landfills are expected to reduce amount of predictable anthropogenic food subsidies (PAFS) for seabirds. To forecast the ecological consequences ...

    Integrating agriculture and conservation: The value of fallow land and its management for farmland and steppe bird conservation 

    Sanz Pérez, Ana (Date of defense: 2021-07-02)

    Extensive farmland ecosystems are widespread and biodiversity-rich, yet they face important human pressures since the beginning of agriculture intensification, which is leading them into a severe biodiversity crisis. As a ...

    Integrating structural and X-chromosome variants in genetic studies of complex diseases 

    Matías Sánchez, Daniel (Date of defense: 2023-10-27)

    [eng] In recent years, the genetics field has placed a significant emphasis on identifying and characterizing genetic factors contributing to complex diseases, alongside environmental factors. Genome-wide association ...

    Integrative Genomic Analyses of Malignant Peripheral Nerve Sheath Tumors 

    Magallón Lorenz, Miriam (Date of defense: 2023-07-07)

    [eng] Malignant peripheral nerve sheath tumors (MPNSTs) are rare soft-tissues sarcomas of the peripheral nervous system (PNS) with poor prognosis and lack of therapeutic options. Complete resection with wide margins of the ...

    Interplay of genetic, epigenetic and transcription factors in the regulation of transcriptional variation in Plasmodium falciparum 

    Michel Todó, Lucas (Date of defense: 2023-03-28)

    [eng] The most severe form of malaria, caused by Plasmodium falciparum parasites, still kills over half a million people every year, most of them children under the age of five. Despite huge research efforts, reduction in ...

    Investigating genetic and mechanistic interactors in familial cardoimyopathy through advanced disease modeling 

    Escribá Piera, Rubén (Date of defense: 2022-03-17)

    Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac disease and a frequent cause of heart failure and sudden cardiac death. HCM is a highly complex condition defined by clinical and genetic heterogeneity. ...

    Investigating the role of mitochondrial dysfunction in the pathogenesis of Parkinsons´s disease using patient-specific derived astrocytes 

    Fernández Carasa, Irene (Date of defense: 2021-06-29)

    Parkinson’s disease (PD) is an incurable, chronically progressive disorder of old age leading to premature invalidity and death. Clinically, PD is characterized by classical motor syndrome linked to a progressive loss of ...

    Investigating the role of testis-mitochondiral genes in Drosophila lethal (3) malignant brain tumor 

    Louzao Boado, Ánxela (Date of defense: 2019-04-30)

    Genetically tractable models such as Drosophila melanogaster may help to identify new approaches to halt malignant growth. During my doctoral thesis, I performed a screen to find mitochondrial genes required for the growth ...

    Jellyfish of the Spanish Mediterranean coast: effects of environmental factors on their spatio-temporal dynamics and economic impacts 

    Canepa Oneto, Antonio Jesús (Date of defense: 2014-10-03)

    During recent years, jellyfish blooms have become in a passionate issue among marine scientists with a series of studies and reviews. The main concern about this blooms are related with ecosystem and socio-economic impacts ...

    Linker histones function in chromosomal RNAs homeostasis and chromatin dynamics 

    Bujosa Rodriguez, Paula (Date of defense: 2023-09-27)

    [eng] Linker histones are essential proteins involved in higher-order chromatin structures and architectural functions. However, their roles extend beyond structure, encompassing various chromatin metabolic processes such ...

    Liquid-liquid phase separation in gene regulation and disease 

    Garcia Cabau, Carla (Date of defense: 2022-05-31)

    Intrinsically disordered (ID) proteins or regions are protein sequences that lack stable secondary and tertiary structures. ID proteins are particularly prone to undergo liquid- liquid phase separation (LLPS). The structures ...

    lnduced Pluripotent Stem cells disease modeling: approaching Gaucher and Tay Sachs 

    Lorenzo Vivas, Erica (Date of defense: 2013-11-05)

    IPSC are potent tools in the creation of disease models for both basic studies on the disease and testing of potential therapeutical drugs. In this context, it has been developed the derivation of iPSC from patient fibroblasts ...

    Long-term growth and functioning of high-elevation Pinus uncinata forests and trees inferred through dendroecology = Creixement i funcionament a llarg termini de boscos i individus de Pinus uncinata inferits mitjançant dendroecologia 

    Galván Candela, Juan Diego (Date of defense: 2014-01-21)

    Iberian Pinus uncinata tree-growth variability and its responses to climate are analyzed by means of dendrochonological methods from an individual- to a population-level scale across its distribution area in the Iberian ...

    L´hemostàsia primària en la trombosi venosa. Biomolècules implicades en la formació del coàgul plaquetari: paper de VAMP8, SERT, SEROTONINA, ADAMTS13 i Factor von Willebrand 

    Llobet i Lorente, Ma. Dolors (Date of defense: 2020-11-06)

    La patologia associada a l’hemostàsia primària ha estat clàssicament relacionada amb diàtesi hemorràgica (malaltia de von Willebrand, Síndrome de Bernard- Soulier, malaltia de Glanzmann, trombopènia, etc) on s’ha valorat ...