Now showing items 158-177 of 229
Capdevila Busquets, Eva (Date of defense: 2016-03-17)
Breast cancer is a very heterogeneous disease with a poor prognostic outcome, largely due to its resistance to current cancer therapies. The balance between cell proliferation and apoptosis plays a critical role in determining ...
Fernández Torras, Adrià (Date of defense: 2022-11-28)
[eng] In the quest for understanding complex biological systems, the scientific community has been delving into protein, chemical and disease biology, populating biomedical databases with a wealth of data and knowledge. ...
Benítez Amaro, Aleyda (Date of defense: 2022-12-22)
[eng] BACKGROUND: Low-density lipoprotein receptor-related protein 1 (LRP1) plays a key role in fatty acid metabolism and glucose homeostasis. In the context of dyslipidemia, LRP1 is positively regulated in the heart. The ...
Ferrer Aparicio, Silvia (Date of defense: 2018-10-18)
Els trastorns neuromusculars pediàtrics són malalties minoritàries causades per un gran nombre de gens, molts d’ells de gran mida i d’estructura complexa, fet que dificulta enormement el diagnòstic molecular i el disseny ...
Bagiński, Błażej Mikołaj (Date of defense: 2022-12-15)
[eng] Tumour progression largely depends on the signalling networks that direct cell viability, growth and dissemination (metastasis). Transforming growth factor beta (TGF-β) and Bone Morphogenetic Protein (BMP) are cytokines ...
Deniz, Ozgen (Date of defense: 2014-05-06)
The nucleosome is the fundamental structural unit of DNA compaction in eukaryotic cells and is formed by the wrapping of 147 bp double stranded DNA around a histone octamer. Nucleosome organization plays a major role in ...
Flores Guri, Oscar (Date of defense: 2014-06-10)
This thesis presents a broad study of the chromatin structure and function with special focus in the nucleosome organization. More specifically, it includes three different but complementary perspectives: i) Analysis of ...
Lacasta Marín, Anna (Date of defense: 2013-02-20)
La peste porcina africana (PPA) es una enfermedad hemorrágica altamente infecciosa que afecta principalmente a cerdos domésticos, causando verdaderos estragos en la producción porcina en los países afectados. El agente ...
Pentinat Pelegrin, Thais (Date of defense: 2013-12-17)
Es coneix que la nutrició en les primeres etapes de la vida és un factor clau que contribueix a la prevalença de la obesitat, així com la resta de característiques de la Síndrome Metabòlica en l’edat adulta (Langley-Evans ...
Fernández Vidal, Leyden (Date of defense: 2015-01-22)
Se ha demostrado en un número de estudios de metagenómica que la adición y la pérdida de genes específicos ha permitido a los microbiomas adaptarse a condiciones ambientales típicas de los entornos. Pero, aún no se conoce ...
Rodríguez García, Mª Ángeles (Date of defense: 2016-10-17)
El colágeno VI es una proteína de la matriz extracelular cuyos defectos conducen a una variedad de trastornos musculares en humanos caracterizados por una debilidad muscular entre otros múltiples síntomas. Tanto el colágeno ...
Ferrero Andrés, Ana (Date of defense: 2020-12-22)
A pesar de las extensas investigaciones durante las últimas décadas, la pancreatitis aguda (PA) continúa siendo un reto para el manejo clínico, con una importante carga de morbilidad, mortalidad y coste, cuando la enfermedad ...
Amézaga Solé, Núria (Date of defense: 2013-09-05)
La proteïna secretada Apoptosis inhibitor expressed by macrophages (AIM) és expressada per macròfags tissulars en condicions d’inflamació. És una glicoproteïna que pertany a la família dels Receptors Scavenger Rics en ...
Ventayol Espinazo, Marina (Date of defense: 2013-02-22)
Les patologies renals s’han convertit en una problemàtica a nivell mundial, en l’actualitat poden afectar a una de cada 9 persones al llarg de la seva vida i porten associats elevats costos econòmics. Malgrat els últims ...
Ivani, Iván (Date of defense: 2016-12-13)
Classical force fields are the core of classical simulations, particularly of molecular dynamics (MD), a technique that is changing our view on the structure, flexibility and function of biological macromolecules. Originated ...
Olivares Requena, Manuel (Date of defense: 2021-02-19)
Marine planktonic copepods play a key ecological role in pelagic food webs. The study of their patterns of activity is fundamental in order to better understand the processes involved in the transfer of energy from lower ...
Carella, Mirco (Date of defense: 2018-07-13)
The Antarctic bottoms harbour rich communities of sponges, which play an important role in structuring benthic habitats. Many Antarctic sponge species have been discovered in the past but most of them were poorly described ...
Pena Rodríguez, Eloy (Date of defense: 2022-07-18)
[eng] Different transdermal drug delivery platforms have been developed for epidermal and follicular targeting. Nanoformulations have been developed, optimised and physicochemically characterised with complementary techniques. ...
Soy Platero, Judit (Date of defense: 2014-07-17)
Arabidopsis thaliana seedling growth and development is influenced by both external (such as light and temperature) and internal (like hormones or circadian clock) factors. In short-day (SD) growing conditions, it is known ...
Peyre, Gwendolyn (Date of defense: 2015-05-12)
The páramo is a high mountain ecosystem that includes the natural and semi-natural habitats located between the montane treeline and the permanent snowline in the humid Northern Andes. Given its recent origin and continental ...