Universitat Pompeu Fabra
Now showing items 1123-1142 of 1296
Genetic variation in humans and the great apes has been amply explored using a wide variety of markers, among them tandem repeats (TRs). Because of the nature of TRs, highly variable in length due to its high mutation rate, ...
COPII vesicles of 60-90nm diameter are known to export secretory cargoes from endoplasmic reticulum (ER). However, they cannot be employed to export bulky cargoes like the collagens that can reach up to 400 nm in length. ...
Aging is the main challenge that humanity will face on the near future. Brain aging is associated with cognitive deficiencies and is the main risk factor for Alzheimer’s Disease (AD). AD is the most common neurodegenerative ...
Alternative splicing of BRAF mRNA can provide a resistance mechanism to BRAF and MEK inhibitors that has been described mostly in BRAF-mutant melanoma. The mechanisms underlying the production of a variety of BRAF mRNA ...
Endometriosis is a chronic inflammatory disease that affects 1 in 10 women of childbearing age. It is characterized by the growth of endometrium in extrauterine locations and is associated with chronic pelvic pain, ...
Chemotherapy-induced peripheral neuropathy (CIPN) is the most common adverse effect of many first-line antineoplastic agents, which negatively affects the quality of life and clinical outcome. Current clinical management ...
The endocannabinoid system is an endogenous neuromodulatory system that regulates a plethora of physiological functions, including the modulation of memory, anxiety, pain, synaptic plasticity and neuronal excitability, ...
Retinoblastoma protein (RB) is a negative regulator of the cell cycle. In response to environmental stress, p38 MAPK phosphorylates RB in the N-terminal region, increasing the affinity of RB for E2F, repressing gene ...
This PhD thesis aimed to understand the impact of temperature at different levels (biology to physics) while performing live-cell imaging. A study and characterization of the role of the temperature during the cell division ...
Dynamic brain states, temporal functional unions of diverse brain areas, are the driving force in our everyday cognition. They help us to flexibly integrate and segregate the assorted information that the environment is ...
Acute myeloid leukemias (AMLs) are a type of cancer where undifferentiated myeloid cells abnormally proliferate. Such phenotype can be caused by the expression of chimeric proteins like PML-RARα and MLL-AF9. Many studies ...
The idea of Terraformation comes from the science fiction literature, where humans have the capability of changing a non-habitable planet to an Earth-like one. Nowadays, Nature is changing rapidly, the poles are melting, ...
Old age comes coupled with frailty and disease and, thus, the ageing of the World’s population have spurred the interest on the causes and mechanisms of senescence. Senescence has long been a mystery, with no single ...
This thesis reports the study of chromatin composition and conformation on the expression of integrated reporters at thousands of genomic locations in the Drosophila genome. We have adapted and improved a technology ...
Identification of signatures of positive selection has long been a major issue for understanding the unique features of any given species. However, only a fraction of human genes have been interrogated. Genes within ...
La coordinació de la citocinesis amb la segregació cromosòmica és essencial per mantenir l’estabilitat cromosòmica durant la proliferació cel•lular. Tant en llevat com en cèl•lules animals, els ponts de cromatina en anafase ...
The main objective of this dissertation is to examine the consequences of bilingualism on speech production. Previous research has shown that bilingual speakers experience a cost compared to monolinguals in a variety of ...
The purpose of my doctoral studies was to develop an algorithm for large-scale analysis of protein sets. This thesis outlines the methodology and technical work performed as well as relevant biological cases involved in ...
Genetically identical cells and organisms growing in homogenous environmental conditions can show significant phenotypic variation. Furthermore, mutations often have consequences that vary among individuals (incomplete ...
This project was carried out in the Cell Signaling Research Group headed by Dr. Carme Caelles at IRB Barcelona. As a part of the research-line that deals with physiological and pharmacological (anti-inflammatory and/or ...
