Universitat Pompeu Fabra
Ara mostrant els elements 565-584 de 1296
Ptf1a/p48 is a pancreas specific bHLH transcription factor that is required at early stages of embryonic development for pancreas formation and, during adulthood, for the proper exocrine pancreatic function. P48 also exerts ...
We found that IgM+IgD- memory (ME-M) B cells formed a large reservoir of intestinal antigen-selected IgM+ lymphocytes distinct from antigen-naïve IgM+ lymphocytes. Human ME-M B cells colonized the intestine early in life, ...
L’IKKα nuclear regula la transcripció gènica i ha estat relacionada amb la progressió del càncer i la metàstasis, tot i que la connexió mecanística no s’entén massa bé. Hem observat que les ...
The self-renewing nature of embryonic stem cells (ESCs) is a consequence of their ability to proliferate while maintaining pluripotency, by means the capacity to differentiate into all adult cell types. Despite the remarkable ...
The first chapter of this thesis describes the study of intestinal stem cells (ISCs) and their relationship to colon cancer. We describe the transcriptional landscape of intestinal epithelial populations through the use ...
Els oòcits de vertebrats es troben aturats a la profase I de la primera meiosi (PI). Durant el procés anomenat oogènesi, els oòctits sintetitzen i emmagatzemen grans quantitats d'ARN missatgers(ARNm)que els seran necessaris ...
Gene regulation is a complex biological process that requires the coordinated interaction of different molecules. The integrity of the underlying mechanisms ensures the correct expression of genes that maintain cell ...
Rheumatoid arthritis, psoriasis, psoriatic arthritis, systemic lupus erythematosus, Crohn’s disease and ulcerative colitis are six of the most prevalent immune-mediated inflammatory diseases (IMIDs) and are associated with ...
Entender cómo las especies se adaptan al ambiente es aún una pregunta sin resolver en el campo de la Biología Evolutiva. Mientras el foco principal siempre ha estado en la base genética, los factores ambientales responsables ...
El objetivo de esta tesis era identificar determinantes genéticos de cáncer de mama con metástasis óseas. Para ello se utilizó un enfoque integral que se sustenta en células humanas de cáncer de mama, modelos experimentales ...
Understanding the molecular basis of human inherited disease is a challenging task due to the complexity of mapping the genotype to the phenotype. The study of diseases running in families has shown that the inheritance ...
Tras la infección por VIH-1, el establecimiento de un depósito de células T en reposo infectadas latentemente con VIH impide la erradicación del virus en pacientes. Para lograr la erradicación, la terapia retroviral existente ...
En este estudio hemos aprovechado la simplicidad numérica del sistema nervioso de la larva de la Drosophila melanogaster para identificar las neuronas responsables que dirigen sus movimientos de acuerdo a ciertas sustancias ...
Protein function is often regulated and controlled by posttranslational modifications, such as oxidation. Although oxidation has been mainly considered to be uncontrolled and nonenzymatic, many enzymatic oxidations occur ...
Upon environmental stresses such as temperature fluctuations or increases in osmolarity, yeast Saccharomyces cerevisiae induces a transcriptional reprograming in order to survive and adapt to the stress. Histone ...
In spite of recent advances in understanding the genetic bases of leukodystrophies, a large number of clinical cases remain unexplained, suggesting that many leukodystrophy-associated genes have yet to be identified. Here ...
The embryo culture system is composed by all those elements with the potential to impact embryo development. Its optimization is required to stabilize in vitro embryo culture and produce reliable and reproducible results ...
Systems pharmacology is the discipline that studies the so-called ‘pharmacological space’ with a holistic and network-based perspective. Its challenge is to shed light on the astonishingly sophisticated biological processes ...
Este estudio cualitativo, exploratorio y descriptivo en cinco ciudades examina las condiciones de trabajo, los riesgos, los factores influyentes y los efectos en salud experimentados por trabajadores inmigrantes en España. ...
Objective: To compare health status (sub-study 1), sleep health (sub-study 2) and health care use (sub-study 3) between the Spanish population and immigrants from the seven leading countries in terms of number of immigrants; ...
