Now showing items 95-114 of 116

    Role of early postnatal nutrition during lactation in offspring metabolic health programming 

    Ribó Gené, Sílvia (Date of defense: 2017-12-01)

    Childhood obesity and overweight can often cause severe complications, including hypertension, dyslipidemia, insulin resistance, type 2 diabetes, and non-alcoholic fatty liver disease, amongst other disorders. Several ...

    Role of the Hippo pathway in planarians 

    Sousa, Nidia de (Date of defense: 2017-07-17)

    A successful cell renewal, which occurs throughout the life of an organism, relies on multiple events, including proliferation and differentiation of progenitor cell populations, and death of unnecessary cells. Out of the ...

    Role of the histone demethylase PHF2 during early neurogenesis 

    Pappa, Stella (Date of defense: 2019-04-10)

    During neural development, signaling molecules and networks of expressed transcription factors cooperate to control cellular fate. Chromatin acting factors are essential players in cell proliferation and differentiation ...

    Role Of The Innate Immunity In The Etiopathogenesis of Primary Sjögren Syndrome: Influence Of Viral And Immunogenetic Factors Related To Cell Adhesion Molecules In Systemic Disease And Autoantibody Profile 

    Gheitasi, Hoda (Date of defense: 2024-01-26)

    [eng] Sjögren Syndrome is a systemic autoimmune disease that affects the exocrine glands, most notably the salivary and lacrimal glands, although it can affect other mucosal surfaces. Inflammation at these sites leads to ...

    The role of the zebrafish tbx5 paralogues during eye, pectoral fin and heart development. 

    Pi Roig, Aina (Date of defense: 2018-04-06)

    Tbx5 is a transcription factor expressed in the developing eyes, heart and upper limbs. Mutations in human TBX5 cause Holt-Oram syndrome (HOS), a condition characterised by heart and upper limb malformations. In zebrafish, ...

    Role of Wnt pathway genes in complex and monogenic phenotypes of low and high bone mass 

    Martínez-Gil, Núria (Date of defense: 2021-03-12)

    Osteoporosis is a complex disease characterized by low bone mass, microarchitectural deterioration, and increased fracture risk. It is the most common bone disease that affects more than 200 million people worldwide and ...

    Sea turtle conservation: genetics and genomics for a better management 

    Barbanti, Anna (Date of defense: 2021-09-23)

    Conservation actions aim to preserve and recover animal and plant species using in-situ or ex- situ strategies. The first, aims to protect and sustain populations in their natural habitat, the second are implemented when ...

    Selective killing of Ras-malignant tisues by exploiting oncogene-induced DNA damage = Eliminación selectiva de tejidos malignos dependientes de RAS mediante la explotación del daño en el ADN inducido por oncogenes 

    Murcia Rosero, Lada (Date of defense: 2019-10-28)

    Most human solid tumors present signs of genomic instability. Activated oncogenes have been proposed to induce genomic instability through the generation of replicative stress. In this thesis, we have sown that the expression ...

    Seqüenciació massiva aplicada a l'epidemiologia d'aigües residuals i a la caracterització de viromes 

    Martínez Puchol, Sandra (Date of defense: 2021-02-18)

    L’objectiu principal de la present tesi doctoral ha estat l’optimització i aplicació de procediments basats en la seqüenciació massiva per a la descripció del viroma associat a l’aigua residual i a altres mostres d’interès ...

    Sortida del virus de l'hepatitis A dels hepatòcits: implicacions en la selecció d'antivirals 

    Castellarnau Serra, Montserrat de (Date of defense: 2018-09-20)

    El virus de l’hepatitis A (HAV), el prototip del gènere Hepatovirus, té una sèrie de característiques que el diferencien de la resta de membres de la família Picornaviridae. Entre aquestes, la via de sortida descrita ...

    Statistical methods for intake prediction and biological significance analysis in nutrimetabolomic studies 

    Castellano Escuder, Pol (Date of defense: 2021-09-08)

    This thesis is the product of three and a half years working on the complex world of metabolomics and nutrition. All the work presented here is focussed on the problems arising from associating and integrating ...

    Study of disseminated high-risk neuroblastoma in the bone marrow niche; from microenvironmental modelling to therapeutic targeting 

    Garcia Gerique, Laura (Date of defense: 2020-12-23)

    Neuroblastoma (NB) is the most common extracraneal solid tumor diagnosed in the first 5 years of childhood and accounts for approximately 15% of all pediatric cancer-related deaths. At the time of diagnosis, about half of ...

    Study of expression levels in MECP2 related disorders using transcriptomics and proteomics: characterizing Rett syndrome and MECP2 duplication syndrome 

    Pascual Alonso, Ainhoa (Date of defense: 2023-07-14)

    [eng] MECP2 is a multifunctional gene involved in multiple processes such as transcription regulation, chromatin remodelling, splicing and miRNA regulation. Malfunction of MECP2 due to loss of function mutations leads to ...

    Study of the components that determine the applicability of pathogenicity predictors in the clinical setting 

    Aguirre Gómez, Josu (Date of defense: 2020-07-14)

    The translation of Next Generation Sequencing (NGS) technologies from the research field to the clinical setting and, specifically, the results obtained in terms of diagnostic yield remain far from expected. This situation ...

    SUMO a la retina: expressió gènica i rellevància en la modificació posttaducciontal del factor de transcripció NRE3 

    Abad Morales, Víctor (Date of defense: 2017-02-03)

    La sumoïlació és una modificació posttraduccional (PTM) que consisteix en la conjugació covalent i reversible d’una proteïna SUMO (Small ubiquitin-like modifier) al residu lisina d’una proteïna diana. Igual que la ubiquitina, ...

    Targeting the TGF-beta pathway of cancer-associated fibroblasts in colorectal cancer metastasis 

    Badia Ramentol, Jordi (Date of defense: 2020-01-14)

    Colorectal cancer (CRC) is the second-highest cause for cancer-related mortality worldwide. Patients suffering from CRC generally don’t die from primary tumours but rather from metastasis, for which there are no effective ...

    Técnicas moleculares para la caracterización microbiológica de los procesos de eliminación de nutrientes en las EDARs = Molecular techniques for microbiological characterization of nutrient removal processes at WWTPs 

    Abzazou Souisa, Tarik (Date of defense: 2016-12-21)

    La presente tesis titulada Técnicas moleculares para la caracterización microbiológica de los procesos de eliminación de nutrientes en las EDARs, se ha desarrollado desde dos puntos de vista, el primero fue la puesta a ...

    Una nueva domesticación molecular en el origen de los euterios: la familia génica Bex/Tceal 

    Navas Pérez, Enrique (Date of defense: 2017-07-28)

    Uno de los mecanismos genéticos que facilitan la innovación evolutiva es la formación de nuevos genes. De entre los procesos que permiten generar nuevos genes, la domesticación molecular de genes transposónicos es uno de ...

    Understanding diversification and dispersion patterns in planarians (Tricladida, Platyhelminthes): form one to hundreds of genes 

    Benítez Álvarez, Lisandra (Date of defense: 2022-06-16)

    Evolutionary Biology offers a set of methods and theories to elucidate the evolutionary processes that lead to the diversification of life. With the development of sequencing technologies, the access to genetic data has ...

    Understanding the processes that shape the genetic diversity of freshwater planarians (Platyhelminthes, Tricladida, Dugesiidae) = Estudi dels processos que modelen la diversitat genètica en les planàries d'aigua dolça (Platyhelminthes, Tricladida, Dugesiidae) 

    Leria Florensa, Laia (Date of defense: 2019-10-28)

    The main goal of the present thesis has been to shed light into the processes that shape the genetic diversity of organisms, focussing in the following factors: the type of reproduction, the morphological diversity of ...