Now showing items 21-40 of 85

    Design of novel compositionally controlled hybrid and ternary nanostructures 

    Dalmases Solé, Mariona (Date of defense: 2019-02-08)

    The size/shape dependent and unique physical and chemical properties presented by nanostructured materials have attracted great attention in several fields such as energy harvesting, optoelectronics and biomedicine, among ...

    Design, synthesis and evaluation of the biological properties of colistin analogues 

    Solé Solé, Judith (Date of defense: 2022-06-03)

    Following the laws of evolution, bacteria are capable of slowly but inexorably acquiring resistance to antibiotic compounds that we have been using for decades. Therefore, bacteria that seemed harmless to most people (such ...

    Design, synthesis and study of coordination complexes with spin crossover or single-molecule magnet properties 

    Diego Creixenti, Rosa (Date of defense: 2022-01-21)

    Spin crossover (SCO) complexes and single-molecule magnets (SMMs) are promising prototypes that can reach magnetic bistability within the molecular scale required for data storage. Despite the extensive library of versatile ...

    The development of new, direct and asymmetric Ni(II) catalysed carbon-carbon bond forming reactions and their application to total synthesis 

    Kennington, Stuart (Date of defense: 2020-12-21)

    This thesis focuses on the search for new methodologies for the direct, stereoselective and catalytic formation of carbon-carbon bonds through the formation of chiral nickel(II) enolate species and the application of such ...

    Development of novel nanomedicines based on polyurethane-polyurea hybrid nanocapsules for cancer theragnosis 

    Bonelli Blasco, Joaquin Daniel (Date of defense: 2022-12-14)

    [eng] Nanomedicine is one of the cutting-edge fields in most of medical applications, specially, in oncology. The possibility to selectively vehiculize and specifically release a wide range of anticancer compounds gained ...

    Diarylethene-based Pt(II) molecular switches: a novel approch to photoactivated chemotherapy 

    Presa i Rodríguez, Andreu (Date of defense: 2016-12-16)

    The photoactivation of metal complexes with potential anticancer activity is a hot topic of current research, as it may lead to the development of more selective and efficient drugs. Photoactivated chemotherapy (PACT) with ...

    Diseño de ligandos β-dicetona y sus agregados metálicos funcionales: estudio cristalográfico y magnético 

    Velasco Amigó, Verónica (Date of defense: 2016-10-28)

    Desde hace años la ciencia del magnetismo ha centrado uno de sus objetivos más ambiciosos en el estudio y creación de dispositivos funcionales a escala molecular. Un ejemplo es el intento de implementación de la computación ...

    Drug discovery with a FRET Biosensor of scaffolding interactions in the N-terminal region of c-Src = Descubrimiento de fármacos mediante un biosensor basado en FRET sensible a las interacciones en la región N-terminal de c-Src 

    Iruela Martin, Guillermo (Date of defense: 2021-09-16)

    c-Src tyrosine kinase is associated with poor prognosis in many cancer processes. Although inhibitors of c-Src kinase activity are known, they have not reached success in clinical trials because of lack of selectivity or ...

    Enolates Go Radical. Stereoselective Radical Alkylation Reactions of Titanium Enolates from N-Acyl Oxazolidinones with Carboxylic Acid Derivatives. Synthesis of Umuravumbolide 

    Pérez Palau, Marina (Date of defense: 2022-07-08)

    This thesis consists in the development of a new methodology of α-alkylation of carbonyl compounds and its application to the synthesis of small molecules with therapeutic interest. In this context, the alkylation of ...

    Estructuras supramoleculares de oro(I) con propiedades luminiscentes. Estudios de agregación y aplicaciones 

    Aguiló Linares, Elisabet (Date of defense: 2017-04-28)

    Hace unos años, en el grupo de investigación donde se ha realizado esta Tesis Doctoral, se estudió un sistema de oro(I)-alquinilo con una fosfina soluble en agua, que dio lugar a la formación de un hidrogel. Este ejemplo ...

    Estudio computacional de reacciones organocatalíticas e interacciones de macrólidos-proteínas del citoesqueleto 

    Castro-Alvarez, Alejandro (Date of defense: 2018-06-25)

    El siguiente trabajo recopila los resultados conseguidos durante el transcurso del periodo Doctoral, el cual se divide en dos secciones: la primera sección aborda distintos estudios sobre reacciones organocatalíticas, ...

    Estudio teórico de enlaces no clásicos 

    Falceto Palacín, Andrés (Date of defense: 2016-12-12)

    En esta tesis se abordan diferentes problemas químicos relacionados con situaciones inusuales de enlace en moléculas. Para algunos de estos problemas se ha aplicado el análisis de pseudosimetría de los orbitales moleculares, ...

    Estudio cinético de la interacción de complejos de metales de transición con moléculas biológicamente relevantes  

    Vázquez Valero, Marta (Date of defense: 2016-07-22)

    El uso de complejos inertes de metales de transición en procesos en los que se involucran moléculas biológicamente relevantes es un sistema ampliamente estudiado en la actualidad. El ejemplo a destacar de estos estudios ...

    Exploring the heavy atom effect and supramolecular assemblies of Au(I) and Pt(II) complexes 

    Romo Islas, Guillermo (Date of defense: 2023-07-14)

    [eng] This thesis is mainly focused on studying the photophysical properties of Au(I), Ag(I), Cu(I), and Pt(II) coordinated compounds. This work can be divided into two parts: on the one hand, the compounds of the group ...

    Fighting bacteria. Synthesis and study of Polymyxin derivates to improve their therapeutic properties 

    Pascual i Pérez, Marina (Date of defense: 2023-11-10)

    [eng] Multidrug resistant bacteria have grown to be a significant medical concern as a result of decades of excessive antibiotic usage and overuse in human medicine, agriculture, and the animal industry. In this context, ...

    Immobilització d’àtoms aïllats i nanopartícules de Pd sobre magnetita. Comportament catalític 

    Caparrós Rodríguez, Francisco Javier (Date of defense: 2018-07-06)

    Les nanopartícules de metalls nobles han atret l’interès dels investigadors en els últims anys degut a la seva elevada activitat i selectivitat en un gran nombre de reaccions catalítiques. No obstant això, les nanopartícules ...

    Insights into the myristoylated c-Src N-terminal Regulatory Element 

    Mohammad Jabeen, Irrem Laareb (Date of defense: 2021-09-23)

    c-Src is a non-receptor tyrosine kinase that controls numerous cellular signaling pathways. c-Src implication in human cancers was brought into the attention in the 1980s. Since its discovery, unveiling of c-Src ...

    Ligandos Supramoleculares en Complejos Metálicos con Propiedades Físicas Relevantes 

    Maxwell Villacorta, Lindley Andrés (Date of defense: 2017-06-16)

    En la primera parte de esta tesis, se basó en la síntesis de ligandos basados en la heptazina y los complejos formados con CuII. Utilizando 2-dipiridilamina para funcionalizar el núcleo de heptazina, (ligando que presenta ...

    Luminescent gold(I) supramolecular assemblies on materials and biological chemistry 

    Pinto Martínez, Andrea (Date of defense: 2021-11-05)

    During the last years, the research group where this Doctoral Thesis has been carried out has been pioneer in the development of different gold(I) complexes and resulting supramolecular assemblages with a wide variety of ...

    Materiales piezoeléctricos derivados del (Bi0,5Na0,5)TiO3-BaTiO3 : preparación y estudio de las propiedades funcionales 

    Cerdeiras Montero, Elena (Date of defense: 2016-11-17)

    Los materiales piezoeléctricos basados en el titanato zirconato de plomo (PZT) son ampliamente utilizados en una gran cantidad de dispositivos electrónicos debido a sus excelentes propiedades eléctricas. Esta mejora de las ...