Ara mostrant els elements 31-40 de 48
Amengual-Rigo, Pep (Data de defensa: 2021-02-15)
Proteins are large macromolecules constituted by amino acids that are responsible for most of the biological processes within a cell. Proteins showing high complementary affinity may bind forming ...
Guindo Martínez, Marta (Data de defensa: 2019-12-18)
Genome-wide association studies (GWAS) have been proven useful for identifying thousands of associations between genetic variants and human complex diseases and traits. However, the identified loci ...
Pertsovskaya, Inna (Data de defensa: 2014-06-25)
Systems Biology opens new frontiers in the studies of complex diseases such as Multiple Sclerosis (MS). The questions that couldn’t be addressed before due to lack of understanding and methodological ...
Lema Amado, Rafael (Data de defensa: 2020-11-19)
The connection between DNA folding and chromatin conformation has been much studied but the relation between the modulation of chromatin conformation and biological processes such as DNA damage, cell ...
Buitrago Ospina, Diana Camila (Data de defensa: 2019-12-16)
Understanding the connection between DNA organization in the nucleus, and cell functioning is one of the most intriguing problems in biology. Although many interdisciplinary efforts have been developed ...
Lobón García, Irene (Data de defensa: 2019-07-26)
Somatic mutations are those that arise after the zygote is formed and are therefore inherited by a fraction of the cells of an individual. Their relevance in certain skin diseases has been known for ...
Meléndez Esteban, Elena (Data de defensa: 2022-03-24)
The ectopic expression of transcription factors Oct4, Sox2, Klf4 and Myc (OSKM) enables the conversion of differentiated cells into pluripotent stem cells, a process known as “reprogramming”. Methods ...
Sfriso, Pedro (Data de defensa: 2016-03-18)
Sequence, structure and dynamics are an indivisible tandem to understand protein function. Luckily, evolution imposed a hierarchical rational between that facilitates the analysis: dynamics are encoded ...
López Ferrando, Víctor (Data de defensa: 2019-12-11)
Single amino acid variants (SAVs) are one of the main causes of Mendelian disorders, and play an important role in the development of many complex diseases. At the same time, they are the most common ...
Ivani, Iván (Data de defensa: 2016-12-13)
Classical force fields are the core of classical simulations, particularly of molecular dynamics (MD), a technique that is changing our view on the structure, flexibility and function of biological ...