MicroRNAs as predictors and therapy for prostate cancer

dc.contributor
Universitat Autònoma de Barcelona. Departament de Medicina
dc.contributor.author
Montes Pérez, Melania
dc.date.accessioned
2015-12-02T07:24:37Z
dc.date.available
2015-12-02T07:24:37Z
dc.date.issued
2015-11-26
dc.identifier.isbn
9788449057779
dc.identifier.uri
http://hdl.handle.net/10803/323366
dc.description.abstract
Prostate cancer (PC) is the most common neoplasia among males from developed countries and the second leading cause of death from cancer in these males. During the last years, serum prostate specific antigen (PSA) has been used as biomarker for PC diagnosis. Although PSA test has increased PC detection, it has a low specificity and leads to over-diagnosis and over-treatment; therefore, it is necessary to improve the current diagnostic methods for PC. In the past decade, urine has received more and more attention for its simplicity, as well as its potential use in identifying new biomarkers as non-invasive detection method. Deregulation of microRNAs (miRNAs) in serum/plasma or tissue has been associated with many diseases including PC, suggesting the possible use of miRNAs as diagnostic biomarkers also in other body fluids. The intent of my PhD research program was to evaluate if miRNAs known to be deregulated in blood or tissue for PC could also be detected in urine from cellular fraction, and characterize the function of the most promising of them. By analysing a large cohort of post-digital rectal exam (DRE) urine samples, we have validated a miRNA panel consisting of 3 urinary miRNAs (miR-648, miR-147b and miR-193a-5p) with a predictive value of area under the curve (AUC): 0,74 In addition, we have determined that miRNAs-miR-28 and miR-210 are under-expressed in PC urine and associated with PC development and progression, mainly affecting PC cell proliferation and migration. Overall, this work introduces novel candidate miRNAs that are aberrantly expressed in PC as diagnostic biomarkers, and perhaps aids in defining how miRNAs might one day serve as anti-cancer therapeutic agents.
dc.format.extent
179 p.
dc.format.mimetype
application/pdf
dc.language.iso
eng
dc.publisher
Universitat Autònoma de Barcelona
dc.rights.license
L'accés als continguts d'aquesta tesi queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons: http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.rights.uri
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
*
dc.source
TDX (Tesis Doctorals en Xarxa)
dc.subject
MicroRNA
dc.subject
Urine
dc.subject
Prostate cancer
dc.subject.other
Ciències de la Salut
dc.title
MicroRNAs as predictors and therapy for prostate cancer
dc.type
info:eu-repo/semantics/doctoralThesis
dc.type
info:eu-repo/semantics/publishedVersion
dc.subject.udc
576
dc.contributor.authoremail
melaniamontes14@gmail.com
dc.contributor.director
Reventós i Puigjaner, Jaume
dc.contributor.director
Morote Robles, Juan
dc.contributor.director
Olivan Riera, Mireia
dc.embargo.terms
cap
dc.rights.accessLevel
info:eu-repo/semantics/openAccess


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