Recent Submissions

Essential functions of Cdt1 and Orc6 during origin licensing 

Guerrero-Puigdevall, Marina (Date of defense: 2025-07-28)

Origin licensing ensures that eukaryotic cells replicate their DNA precisely once per cell cycle. The ORC complex, together with the licensing factors Cdc6 and Cdt1, load the core of the replicative helicase (M2-7), as a ...

Approaching the function of a Lipid transfer protein and various miRNAs in the formation of the Arabidopsis root periderm 

Surís Auguet, Javier (Date of defense: 2025-07-24)

ENG- This thesis aims to explore the two knowledge gaps exposed above. First, we identified a gene that codes for an LTP, which was overexpressed in phellem and other suberized structures of different plant species. To ...

Better together: electron-directed synergistic interactions in Clostridium co-cultures for improved alcohol production 

Feliu Paradeda, Laura (Date of defense: 2025-07-15)

ENG- The need for sustainable alternatives to fossil fuels powers up science in the study of new energy sources. One of these alternatives is anaerobic fermentation, a process in which bacteria transform organic carbon ...

Unió seqüencial de múltiples dominis proteics in vivo i in vitro utilitzant trans-inteïnes ortogonals 

Romero Casañas, Alejandro (Date of defense: 2025-07-08)

ENG- Inteins are a type of protein that can excise themselves from inside a precursor protein sequence, joining the two ends (named exteins) forming a mature protein. This process is termed protein splicing. One particular ...

miRNAs as biomarkers and modulators in asymptomatic carotid stenosis: diagnosis, prognosis, and plaque vulnerability 

Carballo Perich, Laia (Date of defense: 2025-07-04)

ENG-This thesis investigates microRNAs (miRNAs), small RNA molecules involved in gene regulation, as potential non-invasive biomarkers to improve the diagnosis and prognosis of ACAS. Because miRNAs are stable and detectable ...

Desenvolupament i utilització de llevats recombinants com a plataforma vacunal. Seguretat, eficàcia i propietats immunomoduladores 

Nadal i Fullà, Guillem (Date of defense: 2023-11-16)

ENG- Yeast are considered the first microorganisms used by humans to process food and alcoholic beverages. The technology developed from these ancient processes has formed the foundation of modern industrial biotechnology. ...

The impact of imprinted genes on growth and cardiometabolic risk parameters in healthy children 

Mas Parés, Berta (Date of defense: 2025-04-07)

ENG- Imprinted genes are expressed only from one parental allele, either from the mother or the father. They play fundamental roles in fetal and placental growth, as well as in neurobehavioral traits. These genes are ...

Analysis of microbiota patterns linked to pancreatic cancer and their role in host inflammation, oxidative stress, and immune status 

Vilà-Quintana, Laura (Date of defense: 2025-02-07)

ENG- Pancreatic cancer (PDAC) is becoming more common, especially in developed countries, due to risk factors like smoking and alcohol-related chronic pancreatitis (CP). Its hidden location often causes late-stage diagnosis, ...

Untangling lineages: population genetics and phylogenomics of Auxis Rochei and Euthynnus Alletteratus 

Ollé Vilanova, Judith (Date of defense: 2025-01-13)

ENG- The Little Tunny (Euthynnus alletteratus) and the Bullet Tuna (Auxis rochei) are two fish species within the tuna family that are closely related to larger tunas. Although they have a lower market value, thousands of ...

Desenvolupament i implementació clínica d’un nou dispositiu en tècniques d’inspiració forçada mantinguda en tractaments de càncer de mama esquerra amb radioteràpia externa per reduir la dosi al cor 

Romera Martínez, Ingrid (Date of defense: 2024-12-05)

ENG- The radiotherapy treatment for left breast cancer is widely described. One of the long-term undesirable effects of radiotherapy is heart disease, which often manifests as ischemia or myocardial infarction, especially ...

Development of comprehensive non-target bioinformatics and chemometric tools for data filtering and management of mass spectrometry datasets and the chemical compound identification in environmental omics (proteomics, metabolomics, and exposomics) 

Pérez López, Carlos (Date of defense: 2024-11-18)

ENG- Environmental omics is a valuable source of knowledge concerning the chemical compounds and biomolecules occurring in the environment and their molecular effects on the exposed biota. Mass spectrometry (MS), usually ...

Estudi comparatiu de la microbiota oral de l'antiga Tàrraco i la població actual 

González Ruiz, Mercedes (Date of defense: 2024-12-16)

ENG- The present doctoral thesis explores and compares the oral microbiome of ancient dental plaque from burial sites in the ancient Roman city of Tarraco (modern-day Tarragona) with dental plaque from present-day individuals. ...

Fatty acids profile and DNA methylation in the placenta: prevention of cardiometabolic risk and obesity in childhood 

Gómez-Vilarrubla, Ariadna (Date of defense: 2024-07-24)

ENG- The increase in the prevalence of obesity worldwide over the past 50 years has led to obesity being considered the pandemic of the 21st century. Overweight and obesity are under scrutiny because the current pediatric ...

Patró espacio-temporal de la ligno-suberificació de l’arrel d’Arabidopsis: la funció de les CASPARIAN STRIP MEMBRANE DOMAIN PROTEINS-LIKE en l’endodermis i el fel·lema 

Sànchez Guirado, Carla (Date of defense: 2024-07-22)

ENG- Terrestrial plants develop cellular barriers in stems and roots to protect themselves from adverse environmental conditions. These barriers accumulate lignin and suberin in their walls. Lignin is a polyphenolic polymer ...

Microbiota as indicator of intestinal health and modulation strategies 

Oliver Galindo, Lia (Date of defense: 2024-07-17)

ENG- Intestinal microbiota, a diverse community of microorganisms residing in the gastrointestinal tract, plays a crucial role in digestion, nutrient absorption, and immune system regulation, thus influencing overall gut ...

Estudi del transcriptoma de l’Escherichia coli adherent-invasiva (AIEC) per desxifrar les bases moleculars implicades en la seva patogenicitat 

Bonet-Rossinyol, Queralt (Date of defense: 2024-07-12)

Adherent-invasive Escherichia coli (AIEC) is a bacterium found in the intestine that can adhere to and invade intestinal epithelial cells and to survive and replicate inside macrophages. Although it has also been detected ...

Altered glycosylation of prostate specific antigen in prostate cancer: structural analysis and assessment for cancer risk stratification 

Gratacós Mulleras, Anna (Date of defense: 2024-07-05)

The prostate-specific antigen (PSA) is the reference biomarker for prostate cancer (PCa) diagnosis. This biomarker is increased in PCa, but also in benign prostate hyperplasia (BPH) causing a high number of unnecessary ...

Microbial characterization of different bread-making processes and assessment of their impact on human intestinal dysbiosis and inflammatory bowel disease 

Lluansí Salis, Aleix (Date of defense: 2024-07-01)

Inflammatory bowel disease (IBD) is a group of immune-mediated chronic inflammatory intestinal conditions of multifactorial etiology. Unfortunately, there are still some gaps in its pathophysiology and, therefore, in its ...

Polimorfismos de los genes moduladores de la respuesta inmune como predictores de recaída en los pacientes con mieloma múltiple 

Gonzalez Montes, Yolanda (Date of defense: 2024-04-12)

Multiple myeloma (MM) remains an incurable disease despite the incorporation of new therapies. The natural history of disease is of the relapse following treatments due to the re-emergence of the tumour from residual disease ...

New tumour markers for pancreatic cancer based on the altered glycosylation of serum glycoproteins 

Duran Sidera, Adrià (Date of defense: 2023-11-14)

Pancreatic cancer (PaC) is the deadliest of all tumours, with a 5-year survival below 12% and a mortality/incidence ratio of 94.5%. One of the main reasons behind this dismal prognosis is the diagnosis of the disease at ...