Universitat Pompeu Fabra
Now showing items 1-20 of 144
During reprogramming of somatic cells into induced pluripotent stem cells (iPSCs), the epigenome needs to be reset. A prime example of this is the reversal of the silent state of the inactive X chromosome in female cells, ...
Cancer cells are constantly subject to complex stresses in the tumour microenvironment. These stresses encapsulate a wide array of challenging stimuli from physical and mechanical forces to interference in major mechanistic ...
The exocyst is an heterooctameric protein complex that tethers secretory vesicles to the plasma membrane during exocytosis. Each exocytic event is mediated by 10-15 exocysts. However, how multiple exocysts organize in time ...
The short-term effects of air pollution on brain health have come under investigation only recently. Since environmental health studies are often developed entirely by scientists, citizen science is a promising approach ...
El procés de descobriment i desenvolupament de fàrmacs (DDD) és costós tant econòmic com temporalment, i el qual resulta en nivells d'èxit molt reduïts. Una gran quantitat de compostos son analitzats i molts descartats en ...
RNA is a molecule that is released by the different tissues into the circulation. When it is found in the circulation it is called cell-free RNA (cfRNA). This type of molecule has great potential as a noninvasive biomarker ...
Tumors are complex masses composed by multiple cell types, such as cancer associated fibroblasts (CAFs) and macrophages, that interact with each other promoting the tumor progression. Snail1 is a transcription factor ...
Introducción: El Trastorno Depresivo Mayor (TDM) es una enfermedad común que limita severamente el funcionamiento psicosocial y disminuye la calidad de vida. Clínicamente, el diagnóstico pasa por la entrevista clínica ...
Precision and accuracy are paramount for the use of genome editing in clinic, environmental, and industrial applications. These fields require reliable and traceable results to ensure the safety and viability of the resulting ...
Bilingual infants acquire words at a similar rate as monolingual ones, despite navigating a more intricate linguistic environment. The mechanisms behind this phenomenon remain elusive. Our project addressed the potential ...
Though Computed Tomography (CT) plays an essential role in healthcare, several large-scale cohort studies have reported an increased cancer risk following CT-radiation exposure in childhood. Results may be subject to ...
Els pacients diagnosticats amb esquizofrènia o un primer episodi psicòtic (PEP) que consumeixen cànnabis presenten alteracions clíniques diferencials comparats amb els no consumidors. En aquesta tesi doctoral, hem emprat ...
La ínsula es una región cerebral que participa en la regulación del sistema nervioso autonómico, pero su papel en el control cardiovascular central no está bien definido en la actualidad. Realizamos un estudio observacional ...
The statoacoustic ganglion (SAG) is a complex 3D structure composed by neurons in charge of transmitting the information from inner ear hair cells to the CNS. During development, SAG copes with otic tissue demands to ...
Este proyecto se centra en el papel de las células senescentes durante la regeneración muscular desde varios ángulos. Para llevarlo a cabo, hemos desarrollado una técnica novedosa para poder aislar células senescentes ...
Dual-Spiral Dual-Energy Computed Tomography is an emerging technology that is being introduced in Radiotherapy Departments of hospitals because of its cost and simplicity. There is still a lack of literature about its ...
G protein-coupled receptors (GPCRs) are central to cellular signaling and pivotal in drug development. This thesis investigates allosteric communication in GPCRs, crucial for their effective modulation in pharmacotherapy. ...
La malaltia d’Alzheimer (MA) està precedida per una llarga etapa preclínica, en la qual es desenvolupa la patologia cerebral en absència de simptomatologia. La identificació acurada d’aquesta fase preclínica, i un millor ...
Chronic obstructive pulmonary disease (COPD) patients may present different types of systemic manifestations. Iron deficiency (ID) (Fe, an essential nutritional element) is common and can negatively affect exercise tolerance ...
Cancer cells exhibit a synthetic lethal (SL) phenotype when Myc upregulation is combined with antitumor drugs targeting the splicing factor SF3B1. However, the molecular events and mechanisms responsible for this vulnerability ...
