Ara mostrant els elements 2614-2633 de 3216

    Role of microparticles in atherothrombosis 

    Suades Soler, Rosa (Data de defensa: 2014-11-21)

    Cardiovascular disease and, specifically, atherothrombosis is a global health problem with huge devastating consequences. While cardiovascular research has progressed rapidly over the last years, there is still a need ...

    Role of mTOR in the activation of marginal zone B cells by TACI 

    Gentile, Maurizio (Data de defensa: 2014-09-19)

    The marginal zone (MZ) of the spleen contains an innate-like subset of B cells that mount rapid protective antibody responses to polysaccharides and lipids from bloodborne viruses and bacteria. These antigens activate ...

    The Role of mutational processes in the evolution of somatic tissues and malignancy 

    Pich Roselló, Oriol (Data de defensa: 2021-03-24)

    Cells of our body are constantly exposed to events that can create lesions in the DNA. If unremoved by the DNA repair mechanisms, the lesion may lead to a mutational event. Some of these events might drive the transformation ...

    Role of network topology based methods in discovering novel gene-phenotype associations 

    Güney, Emre (Data de defensa: 2012-09-25)

    The cell is governed by the complex interactions among various types of biomolecules. Coupled with environmental factors, variations in DNA can cause alterations in normal gene function and lead to a disease condition. ...

    Role of NFAT5 in macrophage polarisation 

    Tellechea Recarte, Mónica (Data de defensa: 2017-05-19)

    Macrophages are exquisite sensors of tissue homeostasis that can rapidly switch between pro- and anti-inflammatory or regulatory modes to respond to perturbations in the microenvironment. This functional plasticity involves ...

    Role of NK cells in the efficacy of anti-HER2 therapeutic antibodies in breast cancer : from biomarkers to functional checkpoints enhacing ADCC responses 

    Cabo, Mariona (Data de defensa: 2019-11-08)

    HER2 overexpression accounts for approximately 15-20% of breast tumors, and mainstay therapy for these patients includes HER2-specific antibodies in combination with chemotherapy. Although the efficacy of anti-HER2 antibodies ...

    Role of NTRK3 in the extinction of fear memories and streess-coping: studies in a mouse model of panic disorder 

    Amador Arjona, Alejandro (Data de defensa: 2008-07-23)

    The correct development and function of CNS is critical for brain health of the organism. Early or chronic stress causes prominent alterations in brain function, and affects the expression of neurotrophic factors in limbic ...

    Role of PLK1 in steroid hormone signaling in breast cancer cells 

    Wierer, Michael (Data de defensa: 2013-01-13)

    Steroid receptors (SRs) are hormone-induced transcription factors that regulate gene expression by their concerted actions with coregulatory proteins. Performing a quantitative mass spectrometry-based interaction screen ...

    Role of polycomb-like proteins in mouse embryonic stem cell differentiation 

    Condemi, Livia (Data de defensa: 2024-03-07)

    Polycomb repressive complex (PRC) 2 is one of the key regulators of the transcriptional programs, it maintains stem cell properties and guides cell lineage specification. It is a multiprotein complex formed by a core and ...

    Role of PRC2-associated factor EPOP in mouse embryonic stem cells differentiation and early development 

    Chammas, Paul (Data de defensa: 2019-11-29)

    Polycomb repressive complex 2 (PRC2) is a key epigenetic regulator of gene expression. It acts through its histone-modifying activity, as it is responsible of di- and trimethylating the tail of histone H3 on lysine 27 ...

    Role of progranulin in humoral immunity 

    Cassis, Linda (Data de defensa: 2015-10-29)

    Human spleen is continually exposed to blood-borne antigens derived from autologous apoptotic cells and commensal bacteria. This chronic stimulation of the marginal zone (MZ) results in the generation of a steady-state ...

    Role of psychological and culturaly influenced risk factors on symptoms and disability for musculoskeletal disorders. CUPID study (Spain) 

    Vargas-Prada Figueroa, Sergio (Data de defensa: 2014-01-24)

    This PhD thesis is based on the Spanish sample of the International “Cultural and Psychosocial Influences on Disability” (CUPID) study. This multicentre study is coordinated by Professor David Coggon at the University of ...

    Role of RanGTP and spindle assembly factors in cilia assembly and function 

    Mòdol Cano, Aitor (Data de defensa: 2021-04-29)

    El cilio primario es una estructura formada por microtúbulos que sobresale de la superficie celular durante G0 teniendo una función de orgánulo sensor. La importancia del cilio es patente por las ciliopatías como la ...

    Role of Ring1B in ephitelial to mesenchimal transition, invasion and migration of mammary epithelial cells 

    Bosch Gutiérrez, Almudena (Data de defensa: 2009-12-21)

    The Polycomb group (PcG) family of proteins form chromatin-modifying complexes essential for embryonic development, and stem cell renewal and are commonly deregulated in cancer. There are several reports that address the ...

    Role of the amygdala and the hippocampus in conscious perception and emotion processing in patients with drug resistant epilepsy 

    Quevedo Díaz, Marcos (Data de defensa: 2017-12-21)

    Understanding the neural basis of conscious perception is still one of the central unsolved problems in neuroscience. Current theoretical models of conscious processing include the Global Workspace Theory, that proposes ...

    Role of the cellular decapping activator LSM1-7 complex in the replication of positive-strand RNA viruses 

    Galão, Rui Pedro Ribeiro (Data de defensa: 2010-12-01)

    By using the ability of the positive-strand RNA ((+)RNA) virus BMV to replicate in yeast it was previously shown that subunits of the LSm1-7 ring, as well as Pat1 and Dhh1 play an essential role in the transit of the BMV ...

    Role of the endocannabinoid system in the control of the cerebellar functions 

    Cutando Ruiz, Laura (Data de defensa: 2015-07-17)

    The endocannabinoid system is an endogenous neuromodulatory system widely expressed in the central nervous system. It modulates synaptic plasticity and neuronal excitability, and fine-tunes several physiological functions ...

    Role of the LILRB1 HLA class I-specific inhibitory receptor in the regulation of macrophage function 

    Baía, Diogo Nogueira de Graça (Data de defensa: 2014-10-24)

    In the present work the regulatory role played by the HLA class I (HLA-I)-specific LILRB1 inhibitory receptor in human macrophages (MΦ) was addressed. In vitro differentiated monocyte-derived M1 and M2 MΦ expressed different ...

    Role of the MAP kinase Sty1 and the transcription factor Atf1 in euchromatin and heterochromatin dynamics in Schizosaccharomyces pombe 

    Fraile Beneitez, Rodrigo (Data de defensa: 2021-07-23)

    Eukaryotic DNA is condensed inside the nucleus, compacted into chromatin. The structure of chromatin is dynamic, and its accessibility to cellular machinery can be altered depending on the level of chromatin compaction ...

    Role of the protein quality control system in basal and stress conditions in fission yeast 

    Marte, Luis (Data de defensa: 2020-01-31)

    Proteostasis is the proper homeostasis of the concentration and the molecular structure of the proteins, which preserves the integrity of the proteome. Proteo-stasis is constantly challenged by intrinsic and extrinsic ...