Universitat Pompeu Fabra
Now showing items 2614-2633 of 3213
Cells of our body are constantly exposed to events that can create lesions in the DNA. If unremoved by the DNA repair mechanisms, the lesion may lead to a mutational event. Some of these events might drive the transformation ...
The cell is governed by the complex interactions among various types of biomolecules. Coupled with environmental factors, variations in DNA can cause alterations in normal gene function and lead to a disease condition. ...
Macrophages are exquisite sensors of tissue homeostasis that can rapidly switch between pro- and anti-inflammatory or regulatory modes to respond to perturbations in the microenvironment. This functional plasticity involves ...
HER2 overexpression accounts for approximately 15-20% of breast tumors, and mainstay therapy for these patients includes HER2-specific antibodies in combination with chemotherapy. Although the efficacy of anti-HER2 antibodies ...
The correct development and function of CNS is critical for brain health of the organism. Early or chronic stress causes prominent alterations in brain function, and affects the expression of neurotrophic factors in limbic ...
Steroid receptors (SRs) are hormone-induced transcription factors that regulate gene expression by their concerted actions with coregulatory proteins. Performing a quantitative mass spectrometry-based interaction screen ...
Polycomb repressive complex (PRC) 2 is one of the key regulators of the transcriptional programs, it maintains stem cell properties and guides cell lineage specification. It is a multiprotein complex formed by a core and ...
Polycomb repressive complex 2 (PRC2) is a key epigenetic regulator of gene expression. It acts through its histone-modifying activity, as it is responsible of di- and trimethylating the tail of histone H3 on lysine 27 ...
Human spleen is continually exposed to blood-borne antigens derived from autologous apoptotic cells and commensal bacteria. This chronic stimulation of the marginal zone (MZ) results in the generation of a steady-state ...
This PhD thesis is based on the Spanish sample of the International “Cultural and Psychosocial Influences on Disability” (CUPID) study. This multicentre study is coordinated by Professor David Coggon at the University of ...
El cilio primario es una estructura formada por microtúbulos que sobresale de la superficie celular durante G0 teniendo una función de orgánulo sensor. La importancia del cilio es patente por las ciliopatías como la ...
The Polycomb group (PcG) family of proteins form chromatin-modifying complexes essential for embryonic development, and stem cell renewal and are commonly deregulated in cancer. There are several reports that address the ...
Understanding the neural basis of conscious perception is still one of the central unsolved problems in neuroscience. Current theoretical models of conscious processing include the Global Workspace Theory, that proposes ...
By using the ability of the positive-strand RNA ((+)RNA) virus BMV to replicate in yeast it was previously shown that subunits of the LSm1-7 ring, as well as Pat1 and Dhh1 play an essential role in the transit of the BMV ...
The endocannabinoid system is an endogenous neuromodulatory system widely expressed in the central nervous system. It modulates synaptic plasticity and neuronal excitability, and fine-tunes several physiological functions ...
In the present work the regulatory role played by the HLA class I (HLA-I)-specific LILRB1 inhibitory receptor in human macrophages (MΦ) was addressed. In vitro differentiated monocyte-derived M1 and M2 MΦ expressed different ...
Eukaryotic DNA is condensed inside the nucleus, compacted into chromatin. The structure of chromatin is dynamic, and its accessibility to cellular machinery can be altered depending on the level of chromatin compaction ...
Proteostasis is the proper homeostasis of the concentration and the molecular structure of the proteins, which preserves the integrity of the proteome. Proteo-stasis is constantly challenged by intrinsic and extrinsic ...
Osteoarthritis is the most common musculoskeletal disease worldwide, characterized by degradation of the articular cartilage, chronic joint pain and disability. Currently available treatments for osteoarthritis have limited ...
The molecular basis that sustain embryonic stem cell (ESCs) pluripotency and their differentiation in all the types of somatic cells is subject of intensive research. Recently, the potential involvement of RNA Binding ...
