Universitat de Barcelona: Envíos recientes
Mostrando ítems 86-105 de 11839
Mechanics of crypt folding, tissue compartmentalization and collective cell migration in intestinal organoids
[eng] The intestinal epithelium is a monolayer of cells that covers the inner surface of the gut. It protects against pathogens, absorbs nutrients, and secretes hormones and other molecules. This epithelium is folded into ...
Efecto antitumoral de la inhibición de las histonas demetilasas KDM6A/KDM6B en tumores con inactivación genética en SMARCA4 y SMARCB1
[spa] En los últimos años, los estudios de secuenciación masiva del genoma del cáncer han revelado una prevalencia sorprendentemente alta de mutaciones en genes que codifican elementos reguladores de la cromatina. Algunas ...
Identification of risk factors for poor prognosis and impact of different therapeutic strategies in a cohort of hospitalised patients with COVID-19
[eng] In December 2019, an emerging disease was identified in Wuhan, China, about which very little was known at the time: the risk of transmission and the clinical manifestations were not clear. In one of the first ...
Obtención de progenitores hematopoyéticos de sangre periférica: Estrategias de optimización de movilización y aféresis
[spa] INTRODUCCIÓN: En el momento actual el trasplante de progenitores hematopoyéticos (TPH) tanto autólogo como alogénico, constituye un tratamiento fundamental para muchas enfermedades hematológicas y también una ...
Targeting ROS metabolism and hypoxia signaling sensitizes castration-resistant prostate cancer to androgen receptor signaling inhibition
[eng] Most prostate cancer (PCa) patients who undergo Androgen Deprivation Therapy (ADT) exhibit clinical progression, resulting in the development of castration-resistant prostate cancer (CRPC), which is highly metastatic ...
Microbial Biochemistry of Emerging Contaminants and Anthropogenic Organic Matter in the Atlantic and Southern Oceans
[eng] The introduction of anthropogenic organic chemicals into the environment, particularly those exhibiting persistence, bioaccumulation, potential for long-range transport, and toxicity, poses a threat to the well-being ...
Disordered Eating Behaviors in Adolescents with Type 1 Diabetes
[eng] INTRODUCTION: Disordered eating behaviors (DEB) are frequent in people with type 1 diabetes (T1D), presenting a prevalence of 8-55%. As in people without T1D, DEB are more frequent in females than in males and ...
Análisis de los diferentes tipos de endometriosis y su relación con fenómenos de autoinmunidad y otras comorbilidades. Repercusión en la esfera sexual y la calidad de vida
[spa] La endometriosis es una enfermedad compleja de la que se desconocen muchos aspectos importantes sobre su etiología o su patogenia. Está descrito en trabajos científicos previos una relación entre la endometriosis ...
Cellular senescence and inflammatory complement system in bone homeostasis
[eng] Bone loss due to chemotherapy or aging depends on cellular senescence and its secretory phenotype. Even so, it is unknown what factors secreted in the senescent environment contribute to bone loss and osteoporosis. ...
La hiposmia y el trastorno de conducta durante el sueño REM idiopático como marcadores prodrómicos de las alfa-sinucleinopatías
[spa] Las alfa-sinucleinopatías, constituidas por la enfermedad de Parkinson (EP), la demencia con cuerpos de Lewy (DCLw) y la atrofia multisistémica (AMS), presentan una fase prodrómica donde pueden estar presentes ...
Linfoma de células grandes B: Caracterización genética y utilidad en el diagnóstico y pronóstico de la biopsia líquida
[spa] El linfoma difuso de células grandes B (LDCGB) es una neoplasia con gran heterogeneidad clínico-biológica y es el síndrome linfoproliferativo más frecuente en el mundo occidental y el paradigma de linfoma agresivo, ...
Uncovering new therapeutic strategies for motor and cognitive deficits in Huntington's Disease
[eng] The present thesis focuses on studying possible new therapeutic strategies for the treatment of cognitive and motor symptoms associated with Huntington's disease (HD). More specifically, the first work focuses on ...
Utilitat clínica de l’ADN circulant tumoral en pacients amb càncer colorectal
[cat] L’abordatge terapèutic dels pacients amb càncer colorectal (CCR) està definit principalment per la localització tumoral, l’extensió de la malaltia (estadiatge TNM) i el diagnòstic patològic i molecular. Així, en el ...
The role of 4E-BP1 in Huntington’s disease: modulation of translation initiation as a therapeutic strategy
[eng] Precise regulation of translation initiation plays a critical role in learning and memory processes, and defects in this process have been linked to numerous cognitive disorders including neurological disorders such ...
Oncogenes in aggressive B cell lymphomas: dissecting the mechanisms of their aberrant expression and tumorigenic role
[eng] B cell lymphomas are a heterogeneous group of hematological neoplasms. The first tumorigenic events in B cell lymphomagenesis are usually translocations involving defined oncogenes that often lead a block on normal ...
Beta cell dedifferentiation in the treatment of type 2 diabetes
[eng] Type 2 Diabetes Mellitus (T2DM) is the most common type of diabetes (90-95 %) traditionally associated with peripheral insulin resistance that entails compensatory β- cell mass expansion and hyperinsulinemia during ...
Network alterations in Huntington’s disease beyond the classical model of basal ganglia circuitry
[eng] The main objective of this doctoral thesis has been to elucidate the alterations in the dynamics of neural networks in Huntington's disease (HD) beyond the basal ganglia circuit in order to define new therapies based ...
La experiencia educativa en el aula universitaria. Un enfoque fenomenológico-hermenéutico
[spa] Esta tesis doctoral se sitúa en una aproximación holística de la teoría crítica educativa (Freire, 1992; Agamben, 2004; Illich, 2011; Bauman, 2013; Biesta, 2009), mostrando la insuficiencia del proyecto racionalista ...
Interlanguage Pragmatics in Greek as a Foreign Language by Spanish/Catalan Bilinguals: An Analysis of Requests
[eng] The speech act of requests has been widely investigated in the field of Interlanguage Pragmatics (ILP) throughout the years (i.e., Alcón Soler et al., 2005, Barón, 2015; Cohen & Shively, 2007; Martínez-Flor, 2003; ...
El ioga a l'aula com a font de benestar integral i aprenentatge a l'educació secundària: investigació-acció
[cat] Aquesta recerca mesura l’impacte de les pràctiques de ioga a l’aula per establir com el benestar que comporten repercuteix en l’aprenentatge dels alumnes. El ioga a l’aula es presenta com el mètode per crear el context ...
