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Unraveling potential disease modifiers of myotonic dystrophy type 1
[spa] La distrofia miotónica tipo 1 (DM1) es un trastorno multisistémico, progresivo y no tratable con una expansión CTG en el gen DMPK que es la base de la patología. La compleja naturaleza multisistémica de la DM1 ...
Unraveling the biological role of latexin in cell fate specification
Latexin es un gen de respuesta a ácido retinoico (RA) cuya función celular se conoce escasamente. Latexin se encuentra silenciada por un mecanismo de hipermetilación en numerosas líneas tumorales, sugiriendo que ésta podría ...
Unraveling the complex signaling behavior of neurotransmitters and their receptors in the brain
G protein-coupled receptors (GPCRs) are the main acceptors of neurotransmitters, and thus play an important role in communication between neurons. Because of this they are an attractive drug target for multiple neurodegenerative ...
Unraveling the Dynamics and Equilibrium Behavior of Pure and Mixed Micelles: Insights from Microscopic coarse-grain modeling
Aquesta tesi es centra en explorar i controlar els mecanismes darrere de la formació i el comportament dinàmic de micel?les pures i mixtes, les quals són àmpliament utilitzades en moltes indústries. Es proposen simulacions ...
Unraveling the functional roles of sftb-1/SF3B1 and prpf-4/PRPF4B in Caenorhabditis elegans splicing and human disease
Caenorhabditis elegans provides a powerful experimental system for understanding fundamental questions in biomedical research, including the consequences of pre-mRNA splicing alterations. Here, we have applied CRISPR and ...
Unraveling the Fundamental Aspects of Enzyme-powered Micromotors
[eng] Enzyme-powered motors are based on the micro- and nanosized particles that propel thanks to the chemical conversion of enzymes attached on their surface. Recently, these tiny devices have been applied for a plethora ...
Unraveling the molecular mechanisms involved in RCAN-peptide mediated inhibition of calcineurin-NFAT signaling and its potential as an inhibitor of tumor progressions
The calcineurin-NFATc signaling pathway is involved in many aspects of the development and function of the immune, neural, skeletal, cardiovascular and muscular system of vertebrates. Regulators of Calcineurin (RCAN) ...
Unraveling the success of invaders: biotic and abiotic factors determining the invasibility of Mediterranean benthic assemblages by Caulerpa cylindracea
Biological invasions have become one of the most pervasive threats to native ecosystems worldwide, causing species extinctions, disrupting the functioning of ecosystems, altering the provision of critical ecosystem services ...
Unravelling 3D cargo transport dynamics at the microtubule network with super-resolution microscopy
Intracellular transport plays an essential role in a wide variety of fundamental cellular processes required to maintain the internal regulation and organization of cells. Different types of cargos such as organelles, ...
Unravelling cell-particle interactions for the design of new micro- and nanoengineered systems
Els micromaterials i nanomaterials presenten unes propietats fisicoquímiques úniques i controlables, les quals han permès la creació d’eines innovadores per tal d’afrontar alguns dels reptes que presenten diferents branques ...
Unravelling genetic predisposition to familial breast and ovarian cancer: new susceptibility genes and variant interpretation by in silico approaches
Patients with hereditary breast and ovarian cancer (HBOC) in whom a causative pathogenic variant is not identified after genetic analysis may not benefit from prevention, early detection, or precision treatment measures. ...
Unravelling herbicide resistance in corn poppy (Papaver rhoeas L.) to improve integrated weed management strategies
La presencia de biotipos de amapola (Papaver rhoeas L.) resistentes a herbicidas constituye uno de los principales problemas de muchas áreas cerealistas de secano. La solución del mismo pasa por una correcta caracterización ...
Unravelling integrated kinetics during spindle assembly
To ensure faithful segregation of the genetic material, during mitosis the cell assembles the mitotic spindle, a macromolecular machine made of dynamic microtubules and associated proteins. Spindle microtubules are assembled ...
Unravelling mechanistic underpinnings of organometallic nickel chemistry and applications into medicinal chemistry
El níquel, degut a les seves propietats químiques inherents, ofereix patrons de reactivitat versàtils alhora que és abundant a la Terra i més assequible que altres metalls nobles com el pal·ladi o el ròdium. A més, la ...
Unravelling motor protein organization on lysosomal membranes with super-resolution microscopy
This thesis first develops new methods for high-throughput and multi-color super-resolution microscopy (Chapters 2 and 3). Subsequently, I apply these methods to study the organization of motor proteins on the lysosome ...
Unravelling new oncogenic functions of IKKα : towards a better understanding of colorectal carcinogenesis
Numerous studies have shown that the protein kinase IKKα is associated with cancer progression and metastasis in different models. However, the mechanisms underlying IKKα tumorigenic functions are poorly understood. We ...
Unravelling the (micro)plastic threat: the case study of plastic ingestion in Aristeus antennatus and Nephrops norvegicus from the NW Mediterranean Sea and its potential impact on health condition
L’impacte de la contaminació per plàstics, especialment en forma de microplàstics, ha copsat l’atenció dels mitjans durant les últimes dècades. La seva distribució generalitzada i la facilitat per interaccionar amb multitud ...
Unravelling the epigenomic, transcriptomic and cognitive interplay in Down syndrome
The presence of an extra copy of Human Chromosome 21 (HSA21) in Down syndrome (DS) is one of the most complex genetic perturbations compatible with life and is the most common genetic cause of intellectual disability. Here, ...
Unravelling the molecular bases of carotenoid biosynthesis in maize
My research program focused on the elucidation of the mechanisms of carotenoid accumulation in maize (Zea mays). I amplified a putative carotenoid ε-hydroxylase, named CYP97C19, from the yellow maize variety B73. Metabolic ...
Unravelling the molecular complexities of early-stage oestrogen receptor positive breast cancer to identify biomarkers of resistance to endocrine therapy
[eng] 80% of breast cancer (BC) express positive estrogen receptors (ER+) and up to 15% of them also overexpress or amplify the human epidermal growth factor receptor 2 (HER2), which confers a molecular biology and different ...
