Universitat de Barcelona
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Los esteroles son una familia de compuestos triterpénicos que se presentan en forma libre (FS, por sus siglas en inglés) o conjugada, como ésteres (SE), glicósidos (SG) y acilglicósidos de esteroles (ASG). Los esteroles ...
Food intake and whole-body energy balance are regulated by the brain through a sophisticated neuronal network located mostly in the hypothalamus. In particular, the hypothalamic arcuate nucleus (ARC) is a fundamental sensor ...
Vesicle trafficking is fundamental to distribute correctly lipids and proteins among cellular compartments. A complex network of interconnected pathways transport vesicles between organelles to satisfy the cellular demand. ...
Endocytosis and endosomal trafficking are of central meaning in all eukaryotic cells. It enables cells to rapidly modify their surface exposure of signalling complexes, nutrient and ion transporters, to maintain the ...
Los grandes ensamblados macromoleculares presentan unas propiedades mecánicas extraordinarias las cuales los hacen perfectos para su uso con fines muy distintos dentro de la nanotecnología y la biomedicina. El virus diminuto ...
La acuicultura es una importante actividad económica vinculada a la producción de alimentos que se encuentra en etapa de expansión. Sin embargo, la producción de especies carnívoras como la dorada (Sparus aurata) presenta ...
Aquesta tesi descriu el disseny, optimització i implementació de metodologies d’screening versàtils per a la recerca de noves formes sòlides de compostos orgànics. La certesa d’estar desenvolupant la forma sòlida d’un ...
The study of the 3D structural details of protein interactions is essential to understand biomolecular functions at the molecular level. In this context, the limited availability of experimental structures of protein-protein ...
Oncolytic virotherapy with Adenoviruses has regained importance in the past years with the appearance of fresh and promising strategies to deal with tumors. Among the major limitations of this therapy are the immune ...
En el abordaje terapéutico de las enfermedades inflamatorias oculares se han utilizado tanto fármacos antiinflamatorios no esteroideos como corticoides en diferentes formas de dosificación, con la finalidad de devolver la ...
La triple teràpia antitrombòtica (TT), consistent en un anticoagulant oral i la doble antiagregació plaquetària (DAPT), és el tractament recomanat en els pacients amb fibril·lació auricular (FA) sotmesos a un intervencionisme ...
Los bacteriófagos son componentes abundantes y omnipresentes en muchos ambientes naturales, y el cuerpo humano no es la excepción. Del mismo modo que pasa en la naturaleza, los fagos en el cuerpo humano pueden desempeñar ...
[eng] L-type amino acid transporters play key roles in human physiology and are involved in several human pathologies such as primary inherited aminoacidurias (Feliubadaló et al., 1999; Torrents et al., 1999), autism ...
La actividad antiinflamatoria de dosis farmacológicas de glucocorticoides (GCs) los ha convertido en una de las familias de fármacos más utilizados en las últimas décadas a pesar de que su prescripción se halla sujeta a ...
Infectious diseases are still one of the main leading causes of death worldwide mainly due the overuse and the lack of development of new antibiotics. This fact has increased the appearance of multidrug resistance (MDR) ...
Adenosine deaminase acting on transfer RNA (ADAT) is a human heterodimeric enzyme that catalyzes the deamination of adenosine (A) to inosine (I) at the first position of the anticodon of transfer RNAs (tRNAs) (position 34, ...
This research work was aimed at the characterization in vitro, ex vivo and in vivo of nanostructured systems which independently contain a natural flavanone extracted from Eysenhardtia platycarpa and another four flavanones ...
Once a target is identified and characterized, the long pathway to develop a drug starts. In this process, biophysical methods have an important part to play and nowadays are firmly combined at several stages. In this ...
Rosmarinic acid (RA), an ester of caffeic acid and 3,4-dihydroxyphenyl lactic acid, is widely distributed in the plant kingdom, including Satureja khuzistanica, a threatened Iranian plant species. Interest in RA is growing ...
The general goal of this thesis has been to progress oncolytic adenovirus therapy for PDAC, by the incorporation of novel preclinical models to test for patient-specific responses and the generation of oncolytic adenoviruses ...
