Universitat de Barcelona
Now showing items 2609-2628 of 11039
The incremental application of supercomputers to offer solutions to complex problems has motivated the usage of computational modeling tools in drug design pipelines. Specifically, small low-affinity compounds are modified ...
[eng] This industrial Ph.D. thesis aimed to illustrate the presence of the cell-based bioassays throughout the whole life of a drug product and to demonstrate its importance for a complete characterization of a pharmaceutical ...
[eng] Next-generation sequencing (NGS) has revolutionized biomedical sciences, especially in the area of cancer. It has nourished genomic research with extensive collections of sequenced genomes that are investigated to ...
The general aim of this thesis is to develop and apply new computational tools to overcome existing limitations in the analysis of metabolism. This thesis is focused on developing new computational strategies to overcome ...
Nuclear Magnetic Resonance (NMR) spectroscopy is able to produce by a single direct measurement a very high amount of chemical information. However, this information is not always easy to interpret. In fact, the complexity ...
Therapy development in cancer involves several consecutive steps including (1) the identification of the unmet medical need (disease or clinical question), (2) the establishment of clinically relevant resources or models ...
Modern medical treatments are largely based on the ability of pharmacological drugs to interact with a molecular target in the human body (e.g., receptors) in order to evoke a physiological response. Such targets are ...
Photopharmacology is an emerging field that relies on the development of photosensitive compounds to enable precise spatiotemporal control over endogenous proteins. Photochromic ligands· are designed to respond ...
The main aim of this thesis is setting up and using in vivo screening techniques to identify and characterize new photopharmacological compounds targeting endogenous proteins. In order to achieve that aim, the thesis ...
[eng] The interest of this work was to manufacture solid lipid nanoparticles that serve as a vehicle for biomolecules, specifically Chondroitin sulfate and pEGFP plasmid DNA. In the experimental part, the reagents and ...
With the emergence of Industry 4.0 and the increasing availability of sensors and data acquisition systems, modern manufacturing processes are now generating large amounts of process data on a scale as never seen before. ...
Our perceptual system tends to associate higher-pitched sounds with upper spatial positions and smaller visual sizes, and lower pitched-sounds with lower positions and bigger visual sizes. This processes, known as crossmodal ...
This dissertation has the main goal of developing ceramic materials for Mask-Image- Projection-based Stereolithography (MIP-SLA) technology, focused on electronic applications. To accomplish this aim, a low temperature ...
Computing has pushed a paradigm shift in many disciplines, including structural biology and chemistry. This change has been mainly driven by the increase in performance of computers, the capacity of dealing with huge amounts ...
The main goal of this doctoral thesis is the development and optimization of inkjet- based technologies for hybrid electronic circuits manufacturing, as well contribute on the development of the incoming low cost electronics. ...
We have characterized electroluminescent devices based on silicon rich oxide and/or silicon rich nitride. We have discussed the photoluminescence and structural characterization of the active layers and the electrical and ...
Long non-coding RNAs (lncRNAs) are defined as transcripts longer than 200 nucleotides that lack protein-coding potential. Although multiple examples of functional lncRNAs have been described, particularly regulating gene ...
INTRODUCTION: Almost 38 million people were living with HIV at the end of 2020, 73% of whom were estimated to be receiving antiretroviral therapy (ART). The face of HIV has changed greatly since the first highly effective ...
The application of NGS techniques to the study of mature B-cell neoplasms at the research level is providing a large amount of new information, in certain cases with clinical implications, which includes the identification ...
[eng] The use of in vitro models in biomedical research offers an invaluable tool for exploring biological processes of health and disease. While animal models remain highly informative and necessary to ensure clinical ...
