Moles Meler, Ernest (Date of defense: 2015-12-09)
Bearing in mind the absence of an effective preventive vaccine against malaria (WHO, 2015) and its severe clinical manifestations that are principally associated with red blood cell (RBC) destruction ...
Cingolani, Francesca (Date of defense: 2015-07-10)
Sphingolipids (SLs), essential components of cell membranes, are bioactive molecules involved in the regulation of a variety of cellular processes. Ceramide and sphingosine generally mediate anti-proliferative ...
Plà Solans, Helena (Date of defense: 2014-11-13)
Although survival rates of colorectal cancer (CRC) treated with surgery and conventional chemotherapy are high, metastatic CRC still shows acute mortality rates. Current chemotherapeutic treatment ...
Gris Ormo, Georgia (Date of defense: 2015-12-04)
The present Doctoral Thesis focuses on the study of the Sigma-1 receptor (σ1R) in the field of pain. This research has been a part of the preclinical σ1R project focusing on drug discovery of σ1R ligands ...
Hosseini, Seyed Ali (Date of defense: 2015-05-08)
A complete understanding of complex formation between proteins and ligands, a crucial matter for pharmacology and, more in general, in biomedicine, requires a detailed knowledge of their static and ...
Peric, Brezana (Date of defense: 2014-12-17)
Ionic liquids (ILs) are a fairly new and very promising group of compounds. They are often considered as environmentally benign substitutes for traditional volatile organic solvents due to their attractive ...
de la Puente Robles, Beatriz (Date of defense: 2015-12-18)
The present Doctoral Thesis focuses on the study of the sigma-1 receptor (σ1R) in the field of pain. This research has been a part of the preclinical σ1R project focusing on drug discovery of σ1R ligands ...
Püschel, Franziska (Date of defense: 2019-10-31)
Metabolic alterations in cancer cells are primarily caused by oncogenic mutations and cancer cells are more dependent on glucose compared to non-transformed tissue. Targeting the cancer metabolism opens ...
Gil Sepúlveda, Victor Alejandro (Date of defense: 2016-06-09)
The pharmaceutical industry is actively looking for new ways of boosting the efficiency and effectiveness of their R&D programmes. The extensive use of computational modeling tools in the drug discovery ...
Tintoré Gazulla, Maria (Date of defense: 2015-07-01)
The O6-alkylguanine DNA alkyltransferase (hAGT or MGMT) is a DNA repair protein in charge of removing alkyl adducts from the O6 position of guanines, blocking their cytotoxic effects and playing an ...