Pereira Lopes, Selma Patrícia (Date of defense: 2014-02-20)
Trex1 is an exonuclease that was first identified in mammal cells and due to its role in DNA metabolism was conjectured to have a role in DNA damage repair and cancer. It was unexpected to find that ...
Marín Juez, Rubén (Date of defense: 2012-10-26)
The aim of this thesis was to study the function and regulation of two of the major players in the carbohydrate metabolism regulated by insulin, the facilitative glucose transporters GLUT2 and GLUT4, ...
Rius Radrigales, Mònica (Date of defense: 2014-10-30)
The aim of this work is to gain insight in the understanding of the biogenesis of membrane proteins, specially their folding, assembly and ER-exit. Our model is the human cystinuria transporter rBAT- ...
Martín Pérez, Miguel (Date of defense: 2012-10-25)
Stable isotopes, as tracers of the food chain, have been used to characterize the relationship between consumers and their food since isotopic fractionation implies discrimination against certain isotopes. ...
Zare, Fatemeh (Date of defense: 2015-02-05)
Cancer immunotherapy represents a treatment strategy which is being clinically tested to complement surgery, radiotherapy and chemotherapy – the current cornerstones of our fight against cancer. It has ...
Valverde Estrella, Lorena (Date of defense: 2015-02-06)
Aicardi-Goutières Syndrome (AGS) is a rare encephalopathy which mimics a viral intrauterine infection and is characterized by calcifications of the basal ganglia, cerebral atrophy and IFN-a in the ...