Trex1 and Nbs1 as Regulators of the Macrophage Inflammatory Response 

    Pereira Lopes, Selma Patrícia (Date of defense: 2014-02-20)

    Trex1 is an exonuclease that was first identified in mammal cells and due to its role in DNA metabolism was conjectured to have a role in DNA damage repair and cancer. It was unexpected to find that Trex1-/- mice generated ...