Programa de Doctorat en Biomedicina: Recent submissions
Now showing items 41-60 of 1428
Mechanobiology of apoptotic cell clearance in the early embryo
Spontaneous cellular errors can lead to cell death already in early embryo development. Apoptotic cell clearance is thus essential for tissue homeostasis and embryo survival. The outer epithelial layer of the embryo ...
Understanding the impact of early microexon misregulation on zebrafish sleep/wake behaviour
The developing nervous system requires a well-orchestrated and diverse set of proteins, setting the foundation of how an animal perceives the world. Disruptions may result in neurodevelopmental disorders, including autism ...
Temperature exposure and children's brain development
In the context of the ongoing climate change emergency, there is growing concern about the impacts of increasingly extreme temperatures on children’s health, but the effects of extreme temperatures on children's brain ...
Nanosensors quantifying the role of labile zinc on metastasis
This thesis focuses on developing surface-enhanced Raman spectroscopy (SERS)-based nanosensors for real-time quantification of labile zinc in cancer cells and investigating the relationship between zinc dyshomeostasis and ...
Ambient air pollution, cancer risk, and survival using an American Cancer Society prospective cohort
Outdoor air pollution is an established lung carcinogen. In this thesis, we examined associations of outdoor air pollution and incidence of cancers other than lung cancer, as well as the role of air pollution in lung cancer ...
Structural basis of the early exocytosis : a spatio-temporal model of the vesicle tethering machinery
El proyecto tiene como objetivo general descifrar el mecanismo de la exocitosis utilizando biología estructural integrativa, lo cual ayudará a entender cómo las células controlan su crecimiento. Para ello, planteamos generar ...
New insights in cell cycle and meiosis regulation in fission yeast
This thesis is divided into three different sections. The first two sections involve the study of cell cycle and the third section is focused on meiosis. In the first chapter, we have developed a fluorescent-localized cell ...
Implicaciones clínicas de las pruebas de imagen en la evaluación de la sarcopenia asociada a las bronquiectasias
La bronquiectasia es una enfermedad pulmonar compleja cuyas manifestaciones sistémicas han sido poco estudiadas. La presente tesis explora en profundidad la presencia y características de la sarcopenia en pacientes con ...
Ablation of Glut1 drives oxidative phosphorylation and enhances antihumor activity in CD8+ T Cells
The thesis explores the potential of Glut1 ablation to enhance the antitumor activity of CD8+ T cells by inducing a metabolic shift from glycolysis to oxidative phosphorylation. Glut1-KO CD8+ T cells exhibited significantly ...
Adaptative mechanisms of sleep for cognition and memory
Durant el son, els estímuls sensorials externs es filtren mentre el cervell es prepara per consolidar nous records. Aquest equilibri sorgeix d’alternar recursos endògens entre la vigilància de l’entorn i la consolidació ...
Charting the alternative splicing vulnerabilities of cancer
Cancer co-opts alternative splicing to select isoforms that promote disease initiation, progression, and persistence. Drugs targeting either cancer driver splicing factors or specific splicing events can hamper the disease. ...
Attributing heat-related mortality to climate change
Climate change significantly exacerbates public health risks, particularly heat-related mortality. This PhD thesis examines the impact of human-induced climate change on heat-related deaths in Europe, focusing on regional ...
Evaluación del valor pronóstico de la ecografía pulmonar en el infarto agudo de miocardio con elevación del ST (LUS-AMI)
La insuficiencia cardíaca (IC) es un factor pronóstico crucial en pacientes con infarto agudo de miocardio con elevación del ST (IAMEST). La ecografía pulmonar es una técnica ampliamente estudiada en pacientes con insuficiencia ...
New insights into the clinical utility of LMO2
This thesis offers novel information on the clinical utility of LMO2, shown in three different studies. In the first one, we generated a round-robin testing validating the interobserver and interlaboratory reproducibility ...
A novel computational framework for identifying epileptogenic networks based on functional connectivity changes
Esta tesis se centra en mejorar la precisión de los objetivos quirúrgicos en pacientes con epilepsia resistente a los fármacos. Las redes cerebrales epileptogénicas exhiben cambios significativos en la conectividad durante ...
El impacto de la vivienda cooperativa en la salud de las personas: compartir para vivir
El objetivo principal de esta tesis ha sido profundizar y ampliar en el conocimiento sobre la vivienda cooperativa y su impacto en la salud de las personas. Para alcanzar este objetivo, se han diseñado y llevado a cabo ...
Evaluation of topoisomers of snake venom-derived peptides as potential antimicrobial and antitumor agents
This thesis reports an investigation of the effect of topoisomeric modification on the activity of two peptides: crotalicidin (Ctn), a cathelicidin from the venom of a South American rattlesnake, and Ctn[15-34], a Ctn ...
Evolutionary dynamics of cancer drug resistance and prediction of tumor modes of growth
Cancer remains a significant challenge in healthcare and is a leading concern worldwide. Despite advances in cancer therapy and the identification of numerous actionable events, relapse and drug resistance continue to ...
Novel experimental strategies to characterize the genomic architecture of monogenic autoinflammatory diseases: from characterization of aberrant mRNA transcripts to elucidation of the role of post-zygotic variants in desease pathogenesis
Developments in sequencing technologies over the last decade have revolutionized the ability to identify the genetic mechanisms underlying rare autoinflammatory diseases (AIDs), enabling improved characterization and ...
The molecular mechanism of spindle pole focusing: NuMA as a dynein adaptor and microtubule minus end regulator
This project investigates the molecular mechanisms underlying chromosome segregation during eukaryotic cell division. Specifically, it explores the role of the motor protein cytoplasmic dynein 1 in maintaining metaphase ...
