Fraile Beneitez, Rodrigo (Date of defense: 2021-07-23)
Eukaryotic DNA is condensed inside the nucleus, compacted into chromatin. The structure of chromatin is dynamic, and its accessibility to cellular machinery can be altered depending on the level of ...
Demajo Meseguer, Santiago (Date of defense: 2014-02-21)
Acute myeloid leukemia (AML) is frequently linked to epigenetic abnormalities and deregulation of gene transcription, which lead to aberrant cell proliferation and accumulation of undifferentiated ...
Iannone, Camilla (Date of defense: 2014-05-23)
Intron removal is a necessary step for expression of most genes in higher eukaryotes, and alternative splice selection is a highly regulated mechanism that endows a single gene with the possibility to ...
Ortells Campos, Mª Carmen (Date of defense: 2012-07-26)
Adaptive responses allow cells to maintain their growth as well as their proliferative potential under diverse stress conditions. It is known that, growth and proliferation can be suppressed by intense ...
Viéitez Manrique, Cristina (Date of defense: 2014-12-18)
In response to fluctuations in the environment, all living organisms have the ability to sense, respond and adapt to the new conditions. In budding yeast (Saccharomyces cerevisiae) there is a massive ...
Ruiz Roig, Clàudia (Date of defense: 2011-12-02)
A Saccharomyces cerevisiae, un increment de la temperatura comporta diversos efectes deleteris en l’organització interna de la cèl∙lula i indueix una inducció ràpida, massiva i transitòria d’expressió ...
Martín de Dios, Laura (Date of defense: 2024-05-06)
La organización del genoma en células mamíferas sigue siendo en gran parte desconocida. Un nivel fundamental de organización se considera el bucle de cromatina, que consiste en una región de ADN atrapada ...