Serra Bardenys, Gemma (Date of defense: 2019-12-12)
Oxidation of histone H3 (H3K4ox) by lysyl oxidase-like 2 (LOXL2) is important in triple-negative breast cancer (TNBC) cells to generate compacted heterochromatin regions. However, the molecular mechanisms ...
Bosch Colom, Jaume (Date of defense: 2012-12-03)
This doctoral thesis describes the evaluation of analytical methodologies to detect human growth hormone (hGH) abuse in sport. Two main strategies are studied and compared. The first (direct method) ...
Crespo Bojorque, Paola (Date of defense: 2016-12-02)
La consonancia es una de las características más salientes de la música. A pesar de su papel fundamental en la música occidental, sus orígenes siguen siendo controversiales. Por lo tanto, la comprensión ...
Millán Ariño, Lluís (Date of defense: 2013-11-25)
Seven linker histone H1 variants exist in human somatic cells with distinct prevalence among cell types and during differentiation. Despite being key chromatin structural components, it remains elusive ...
Mariotti, Marco (Date of defense: 2013-12-13)
Selenoproteins are a diverse class of proteins containing selenocysteine, the 21st aminoacid. Selenocysteine is inserted co-translationally, recoding very specific UGA codons through a dedicated ...
Segura Puimedon, Maria (Date of defense: 2012-11-20)
Williams-Beuren syndrome (WBS) is a neurodevelopmental disorder caused by the common deletion of 26-28 contiguous genes in the 7q11.23 region, which poses difficulties to the establishment of ...
Timón Pérez, Krystal (Date of defense: 2018-12-18)
During mitosis, the microtubules organize a bipolar spindle that segregates the chromosomes. In higher eukaryotes, these microtubules are nucleated through three different pathways involving the centrosomes ...
Carrignon, Simon (Date of defense: 2019-11-15)
In this thesis, we have quantified the influence of content-dependent biases in social learning strategies. Our theoretical framework combines agent-based models and Bayesian inference to measure ...
Manaca, Maria Nélia Joquim (Date of defense: 2011-09-27)
Past and present uses of DDT and pyrethroids have led to their incorporation into humans, mainly through the food chain and sometimes by direct exposure. The present work focuses on establishing the ...
Serra Pascual, Selma A. (Date of defense: 2011-07-04)
Migraine is one of most disabling neurological disorders for which the genetic and molecular mechanisms are not fully resolved. This PhD thesis has focused on the functional characterization of two new ...