Calvo Vidal, Verónica Alejandra (Date of defense: 2009-07-17)
Germ-line mutations in the breast cancer susceptibility gene BRCA1 strongly increase the risk of developing breast and ovarian cancer in women. Different hypothesis have been proposed to explain this ...
Martínez Bosch, Neus (Date of defense: 2011-09-26)
Pancreatic cancer is nowadays one of the neoplasms with worst prognosis, so research towards the discovery of new molecular targets for therapy and diagnosis is more than urgent. In this direction, ...
Guix Arnau, Marta (Date of defense: 2017-12-19)
Targeted therapies against the Epidermal Growth Factor Receptor (EGFR) are useful to treat many human cancers such as non-small cell lung cancer, colorectal cancer and head and neck cancer. However, the ...
Pons i Vigués, Mariona (Date of defense: 2010-11-23)
The general objective of this dissertation is to study breast cancer screening and specifically social inequalities by social class and country of origin and its relationship with decreasing mortality. ...
Antonell Boixader, Anna (Date of defense: 2006-04-20)
En aquest treball es presenta l'evolució molecular i estudi funcional de gens localitzats a les duplicacions segmentàries de la regió 7q11.23, implicada en la Síndrome de Williams-Beuren (SWB). S'ha ...
Malouf Sierra, Jorge (Date of defense: 2012-01-20)
El dolor es un síntoma muy común y la práctica asistencial diaria nos muestra que, a pesar de todas las herramientas que tenemos para combatirlo, aún somos incapaces de controlarlo adecuadamente en ...
Schroeder, Michael Philipp (Date of defense: 2014-11-21)
Cancer is a complex disease caused by somatic alterations of the genome and epigenome in tumor cells. Increased investments and cheaper access to various technologies have built momentum for the generation ...
Pérez Núñez, Iván (Date of defense: 2023-03-13)
Cancer stem cells (CSCs) fuels tumours and are involved in therapy resistance, yet their contribution immunotherapy resistance and immunological properties are poorly understood. Herein, we show that ...
Subtil Rodriguez, Alicia (Date of defense: 2007-06-27)
El gen humano 11-HSD2 es un modelo para investigar la contribución de los efectos de los receptores de esteroides en células de cáncer de mama. El análisis del promotor mostró que la región ...
García López, Roberto (Date of defense: 2018-04-06)
Genome-wide association studies have been very useful tools in the last years to relate genes and diseases. Thereby, single nucleotide polymorphisms have been linked to increased ORMDL3 expression and ...