Universitat Pompeu Fabra
Now showing items 264-283 of 1297
Modern biology relies on genomic references to perform analyses in most studies. High-quality de novo genome assemblies are key to having references containing all the genomic content of a species. Here I use avant-garde ...
Several rainforest hunter-gatherer groups in south-east Asia are characterized by specific morphological features including a particularly dark skin color (D), an extremely short stature (S), the development of woolly hair ...
The intrinsic complexity and dynamic nature of B-lymphocytes make them ideal for in-depth analysis using single-cell technologies. Secondary lymphoid organs (SLOs) are central in B-lymphocyte activation and differentiation, ...
Subcellular compartmentalisation of metabolic enzymes may elicit specific cellular functions by establishing a unique metabolic environment. Indeed, the nuclear translocation of certain metabolic enzymes impacts epigenetics ...
Neural microexons are the most conserved type of alternative splicing, suggesting a strong functional relevance. Consistently, mutation of their master regulators leads to dramatic neurodevelopmental alterations and ...
Short explanation English To reveal how RBM10 loss contributes to development and cancer we have established Rbm10 constitutive and conditional knockout mouse models and have analyzed phenotypes at the organismal and ...
RNA modifications, collectively known as the ‘epitranscriptome’, play a major role in multiple biological processes, including splicing regulation, gene expression regulation and antibiotic resistance. Unfortunately, ...
Cancer stem cells (CSCs) fuels tumours and are involved in therapy resistance, yet their contribution immunotherapy resistance and immunological properties are poorly understood. Herein, we show that within tumour phenotypic ...
Virtually all living organisms are challenged by changes in their environment, such as sudden increases in osmolarity. To cope with these stresses, cells have developed stress responses that tune every aspect of cell ...
Designing novel drugs is a complex process which requires finding molecules in a vast chemical space that bind to a specific biomolecular target and have favorable physio-chemical properties. Machine learning methods can ...
This thesis describes the application of Next Generation Sequencing, especially RNA sequencing, on the investigation of the pathogenic yeast Candida parapsilosis. Pathogenic yeasts of the Candida clade are one of the most ...
Dual-specificity tyrosine-regulated kinases (DYRKs) are a conserved family of protein kinases present in all eukaryotes. In mammals, the association of DYRKs with a wide variety of putative substrates and interactors, in ...
Spinal Muscular Atrophy (SMA) is an autosomal recessive neuromuscular disorder characterized by the degeneration of the lower motor neurons. It is caused by homozygous loss or mutations in the Survival Motor Neuron 1 (SMN1) ...
Recent advances in high throughput technology have opened the door to systematic studies of epigenetic mechanisms. One of the key components in the regulation of the cell cycle and differentiation is the retinoblastoma ...
Since the first peopling of the region, multiple demographic events have occurred generating a complex genetic landscape in North Africa characterized by high genetic heterogeneity and constant gene flow from surrounding ...
The history of North Africa is extremely complex, and it has been difficult to assess from genetic and archeological data whether early populations were replaced by later migrations or if there has been continuous ...
The human colonization of worldwide landmasses occurred through complex patterns of dispersal and admixture. At the same time, the survival in the different areas of the world depended on the adaptation to new habitats ...
El descubrimiento de las duplicaciones segmentarias (DS) o Low Copy Repeats (LCRs) ha permitido definir nuevos mecanismos evolutivos mediados, en gran parte, por duplicación génica. Las DS son responsables de reordenamientos ...
Descriure l’ agregat d’àrees petites amb un elevat risc de mortalitat detectat a la zona sud-oest d’Espanya, en particular a les províncies de Huelva, Sevilla i Cadis (HSC) durant el període 1987-1995, analitzar la seva ...
Podrán cuestionarse históricamente la existencia de un vínculo entre las opresiones de poder, la reproducción y la salud en general sin embargo no cabe la menor duda que punto y aparte de nuestras diferencias genéticas o ...
