dc.contributor
Universitat Jaume I. Escola de Doctorat
dc.contributor.author
Guarque-Chabrera, Julian
dc.date.accessioned
2023-07-27T09:44:07Z
dc.date.available
2023-07-27T09:44:07Z
dc.date.issued
2023-07-20
dc.identifier.uri
http://hdl.handle.net/10803/688871
dc.description
Doctorat internacional
ca
dc.description.abstract
The present thesis investigates the cerebellum-IL interactions in drug-induced memories and their anatomical pathways. To do so, we 1) assessed activity and perineuronal nets (PNNs) expression in the posterior cerebellum of IL-inactivated rats, 2) digested PNNs in LVIII at different time points of the learning process, and 3) created an anatomical map of the ascending and descending cerebellum-IL reciprocal pathways using tracing agents. First, IL inactivation promoted cocaine-induced memory acquisition and upregulated cFos and vGluT2 activity around neurogranin+ Golgi interneurons and PNN expression in the posterior cerebellum. Second, LVIII PNNs enzymatic digestion disrupted short-term cocaine memory and facilitated reinstatement of cocaine-induced memory probably by preventing the consolidation of extinction. Third, our anatomical maps show that LVIII via the interposed DCN might contact VTA and then contact IL, and IL might send projections to both interposed DCN and inferior olive and these areas that reach LVIII.
ca
dc.format.extent
287 p.
ca
dc.publisher
Universitat Jaume I
dc.rights.license
L'accés als continguts d'aquesta tesi queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons: http://creativecommons.org/licenses/by-nc-sa/4.0/
ca
dc.rights.uri
http://creativecommons.org/licenses/by-nc-sa/4.0/
*
dc.source
TDX (Tesis Doctorals en Xarxa)
dc.subject
Infralimbic cortex
ca
dc.subject
Interposed DCN
ca
dc.subject
Inferior Olive
ca
dc.subject.other
Ciències de la salut
ca
dc.title
Functional interactions of Infralimbic-Cerebellum pathways in cocaine-induced preference memory
ca
dc.type
info:eu-repo/semantics/doctoralThesis
dc.type
info:eu-repo/semantics/publishedVersion
dc.contributor.director
MIQUEL, MARTA
dc.contributor.director
Khodakhah, Kamran
dc.contributor.tutor
MIQUEL, MARTA
dc.rights.accessLevel
info:eu-repo/semantics/openAccess
dc.identifier.doi
http://dx.doi.org/10.6035/14112.2023.23864
ca
dc.description.degree
Programa de Doctorat en Ciències Biomèdiques i Salut