Degradation of perineuronal nets in the cerebellum to prevent relapse of drug seeking

llistat de metadades

Director

MIQUEL, MARTA ORCID

Tutor

Cerezo García, Miguel ORCID

Date of defense

2023-03-03

Pages

196 p.



Department/Institute

Universitat Jaume I. Escola de Doctorat

Doctorate programs

Programa de Doctorat en Ciències

Abstract

Drug addiction can be associated with the ability of certain substances to hijack natural learning and memory mechanisms. This thesis focuses on the study and manipulation of cerebellar perineuronal nets (PNNs) following cocaine self-administration. These structures regulate synaptic architecture and have been related with learning, memory and addiction. Our results show that cocaine self-administration, in an extended access pattern, dynamically regulates plasticity conditions in the cerebellum during withdrawal and increases the expression of PNNs after prolonged abstinence. This is consistent with the observed expression levels of essential components of PNNs. These results support the theory that PNNs around Golgi interneurons are necessary mechanisms for the persistence of drug-induced memories and their regulation may be linked to their stabilisation.

Subjects

615 - Pharmacology. Therapeutics. Toxicology. Radiology

Knowledge Area

Ciències

Note

Doctorat internacional

Recommended citation

Documents

Llistat documents

2023_Sanchez Hernández_Aitor.pdf

10.43Mb

 

Rights

L'accés als continguts d'aquesta tesi queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons: http://creativecommons.org/licenses/by-nc-sa/4.0/
L'accés als continguts d'aquesta tesi queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons: http://creativecommons.org/licenses/by-nc-sa/4.0/

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