Study of disseminated high-risk neuroblastoma in the bone marrow niche; from microenvironmental modelling to therapeutic targeting 

    Garcia Gerique, Laura (Date of defense: 2020-12-23)

    Neuroblastoma (NB) is the most common extracraneal solid tumor diagnosed in the first 5 years of childhood and accounts for approximately 15% of all pediatric cancer-related deaths. At the time of diagnosis, about half of ...

    Targeting the TGF-beta pathway of cancer-associated fibroblasts in colorectal cancer metastasis 

    Badia Ramentol, Jordi (Date of defense: 2020-01-14)

    Colorectal cancer (CRC) is the second-highest cause for cancer-related mortality worldwide. Patients suffering from CRC generally don’t die from primary tumours but rather from metastasis, for which there are no effective ...