Now showing items 87-106 of 115

    Range expansion in the evolutionary history of western palaeartic aquatic coleoptera = Expansiones de rango durante la historia evolutiva de coleópteros acuáticos en el Paleártico occidental 

    García Vázquez, David (Date of defense: 2016-12-16)

    CHAPTER 1: Reconstructing ancient Mediterranean crossroads in Deronectes diving beetles Aim: To reconstruct the evolutionary history of a genus of freshwater beetle with a pan- Mediterranean distribution, to test classic ...

    Regeneració i homeòstasi a les planàries: gens i vies de senyalització implicats en l'organogènesi 

    González Sastre, Alejandro (Date of defense: 2017-07-27)

    En aquesta tesi, titulada “Regeneració i homeòstasi a les planàries: gens i vies de senyalització implicats en l'organogènesi”, s’aprofundeix en l’estudi dels processos responsables de l’organogènesi a la planària d’aigua ...

    The regulatory landscape of Drosophila imaginal disc regeneration 

    Vizcaya Molina, Elena (Date of defense: 2018-12-19)

    One of the most important questions in regenerative biology is how and when genes change expression to trigger regeneration programs. Resetting of gene expression patterns during injury responses is shaped by the coordinated ...

    Relevant deubiquitinating enzymes in cilium formation and function in the retina: USP48 

    Sánchez Bellver, Laura (Date of defense: 2023-12-15)

    [eng] Ciliopathies encompass a broad group of heterogeneous inherited disorders associated with dysfunction of the cilium, a ubiquitous microtubule-based organelle that translates extracellular stimuli into cellular ...

    Rol de la microbiota en pacientes con bronquiectasias no asociadas a la fibrosis quística 

    López Aladid, Rubén (Date of defense: 2022-10-20)

    [spa] El pulmón siempre se ha considerado estéril. Sin embargo, el campo de la microbiota pulmonar se ha visto revolucionado por el avance de las técnicas moleculares. Cada individuo tiene un perfil de microbiota único, ...

    Rol de la mitocòndria en el control de la homeòstasi cel·lular en planàries 

    Rosselló Xamena, Maria (Date of defense: 2021-12-10)

    El manteniment de l’homeòstasi en organismes adults és cabdal per la continuïtat dels individus; desregulacions d’aquest equilibri porten a l’aparició de malalties. La planària és un model d’estudi en regeneració i remodelació ...

    Rol del gen de pigmentació MC1R en la susceptibilitat a malalties neurodegeneratives 

    Tell Martí, Gemma (Date of defense: 2018-05-07)

    El gen MC1R (codi OMIM: #155555) codifica pel receptor de la melanocortina 1 (MC1R) que s’expressa majoritàriament a la membrana dels melanòcits i està implicat en la regulació de la síntesi de melanina. El gen MC1R és ...

    Role of early postnatal nutrition during lactation in offspring metabolic health programming 

    Ribó Gené, Sílvia (Date of defense: 2017-12-01)

    Childhood obesity and overweight can often cause severe complications, including hypertension, dyslipidemia, insulin resistance, type 2 diabetes, and non-alcoholic fatty liver disease, amongst other disorders. Several ...

    Role of the Hippo pathway in planarians 

    Sousa, Nidia de (Date of defense: 2017-07-17)

    A successful cell renewal, which occurs throughout the life of an organism, relies on multiple events, including proliferation and differentiation of progenitor cell populations, and death of unnecessary cells. Out of the ...

    Role of the histone demethylase PHF2 during early neurogenesis 

    Pappa, Stella (Date of defense: 2019-04-10)

    During neural development, signaling molecules and networks of expressed transcription factors cooperate to control cellular fate. Chromatin acting factors are essential players in cell proliferation and differentiation ...

    Role Of The Innate Immunity In The Etiopathogenesis of Primary Sjögren Syndrome: Influence Of Viral And Immunogenetic Factors Related To Cell Adhesion Molecules In Systemic Disease And Autoantibody Profile 

    Gheitasi, Hoda (Date of defense: 2024-01-26)

    [eng] Sjögren Syndrome is a systemic autoimmune disease that affects the exocrine glands, most notably the salivary and lacrimal glands, although it can affect other mucosal surfaces. Inflammation at these sites leads to ...

    The role of the zebrafish tbx5 paralogues during eye, pectoral fin and heart development. 

    Pi Roig, Aina (Date of defense: 2018-04-06)

    Tbx5 is a transcription factor expressed in the developing eyes, heart and upper limbs. Mutations in human TBX5 cause Holt-Oram syndrome (HOS), a condition characterised by heart and upper limb malformations. In zebrafish, ...

    Role of Wnt pathway genes in complex and monogenic phenotypes of low and high bone mass 

    Martínez-Gil, Núria (Date of defense: 2021-03-12)

    Osteoporosis is a complex disease characterized by low bone mass, microarchitectural deterioration, and increased fracture risk. It is the most common bone disease that affects more than 200 million people worldwide and ...

    Sea turtle conservation: genetics and genomics for a better management 

    Barbanti, Anna (Date of defense: 2021-09-23)

    Conservation actions aim to preserve and recover animal and plant species using in-situ or ex- situ strategies. The first, aims to protect and sustain populations in their natural habitat, the second are implemented when ...

    Selective killing of Ras-malignant tisues by exploiting oncogene-induced DNA damage = Eliminación selectiva de tejidos malignos dependientes de RAS mediante la explotación del daño en el ADN inducido por oncogenes 

    Murcia Rosero, Lada (Date of defense: 2019-10-28)

    Most human solid tumors present signs of genomic instability. Activated oncogenes have been proposed to induce genomic instability through the generation of replicative stress. In this thesis, we have sown that the expression ...

    Seqüenciació massiva aplicada a l'epidemiologia d'aigües residuals i a la caracterització de viromes 

    Martínez Puchol, Sandra (Date of defense: 2021-02-18)

    L’objectiu principal de la present tesi doctoral ha estat l’optimització i aplicació de procediments basats en la seqüenciació massiva per a la descripció del viroma associat a l’aigua residual i a altres mostres d’interès ...

    Sortida del virus de l'hepatitis A dels hepatòcits: implicacions en la selecció d'antivirals 

    Castellarnau Serra, Montserrat de (Date of defense: 2018-09-20)

    El virus de l’hepatitis A (HAV), el prototip del gènere Hepatovirus, té una sèrie de característiques que el diferencien de la resta de membres de la família Picornaviridae. Entre aquestes, la via de sortida descrita ...

    Statistical methods for intake prediction and biological significance analysis in nutrimetabolomic studies 

    Castellano Escuder, Pol (Date of defense: 2021-09-08)

    This thesis is the product of three and a half years working on the complex world of metabolomics and nutrition. All the work presented here is focussed on the problems arising from associating and integrating ...

    Study of disseminated high-risk neuroblastoma in the bone marrow niche; from microenvironmental modelling to therapeutic targeting 

    Garcia Gerique, Laura (Date of defense: 2020-12-23)

    Neuroblastoma (NB) is the most common extracraneal solid tumor diagnosed in the first 5 years of childhood and accounts for approximately 15% of all pediatric cancer-related deaths. At the time of diagnosis, about half of ...

    Study of expression levels in MECP2 related disorders using transcriptomics and proteomics: characterizing Rett syndrome and MECP2 duplication syndrome 

    Pascual Alonso, Ainhoa (Date of defense: 2023-07-14)

    [eng] MECP2 is a multifunctional gene involved in multiple processes such as transcription regulation, chromatin remodelling, splicing and miRNA regulation. Malfunction of MECP2 due to loss of function mutations leads to ...