Polycyclic group optimization in 11β-HSD1 inhibitors and their pharmacological evaluation 

Leiva Martínez, Rosana (Date of defense: 2017-09-22)

The present PhD Thesis evolves around the design, synthesis and pharmacological evaluation of novel 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors. Given that the enzyme active site includes a hydrophobic ...