Design, synthesis and biological evaluation of novel molecules with the capacity of inducing the degradation of different proteins by direct signaling to the proteasome 

Alqahtani, Abdulateef (Date of defense: 2023-10-25)

[eng] In 2001, the initial hypothesis of targeted protein degradation (TPD) was born to announce the launching of a new era of therapeutics development not by inhibiting a component of ubiquitin-proteasome system as small ...