Browsing Departament de Farmacologia, Toxicologia i Química Terapèutica by Subject "615"

Now showing items 1-20 of 31

    Addressing Alzheimer's disease through innovative mechanisms 

    Martínez Conde, Noemí (Date of defense: 2025-02-07)

    [eng] Alzheimer’s disease (AD) remains a major unmet medical need, with no effective disease- modifying treatments available despite decades of research and a growing socioeconomic burden associated with its increasing ...

    Characterization of epigenetic and transcriptional changes in aging and Alzheimer’s disease 

    Cosín Tomàs, Marta (Date of defense: 2017-02-28)

    Epigenetic changes are currently recognized as part of the aging process and have been implicated in many age-related chronic diseases such as Alzheimer’s disease (AD). The term epigenetics includes a variety of processes ...

    Chloroacetamides as Valuable Synthetic Tools to Access Nitrogen-Containing Heterocycles Using Both Radical and Non-Radical Processes 

    Montiel Achong, Juan Andrés (Date of defense: 2016-12-20)

    Durante este trabajo de tesis doctoral se ha demostrado que las cloroacetamidas son intermedios de gran utilidad para la síntesis de heterociclos nitrogenados a través de procesos radicalarios o no radicalarios. En este ...

    Common scaffolds for the enantioselective synthesis of marine, plant, and amphibian cis-decahydroquinoline alkaloids 

    Pinto, Alexandre (Date of defense: 2017-09-28)

    Chiral amino alcohol derived lactams are a valuable scaffold for the enantioselective synthesis of alkaloids. In the present thesis the potential of this methodology was expanded and to demonstrate the synthetic utility ...

    Design and synthesis of heterocyclic compounds potentially antitumor by enzymatic inhibition 

    Lizano Gispert, Enric (Date of defense: 2020-07-24)

    This doctoral thesis is focused on the investigation and development of new compounds directed to different cancer and tropical diseases targets. Drug resistance, as well in cancer as in tropical diseases, is a hurdle which ...

    Development of a divergent strategy towards the synthesis of lycopodium alkaloids 

    Saborit Villarroya, Gisela (Date of defense: 2016-07-19)

    En la present tesi doctoral s’ha desenvolupat una estratègia per obtenir els esquelets dels quatre alcaloides licopodi representatius a partir d’un mateix intermedi sintètic comú 1, de manera semblant al procés que té lloc ...

    Development of New Multicomponent Processes based on Unexplored Chemistry of Isocyanides: Access to Heterocyclic Scaffolds and Applications 

    Ghashghaei, Ouldouz (Date of defense: 2017-09-26)

    1. It was observed that the interaction of imines and isocyanides in the presence of a Lewis acid can lead to a variety of scaffolds including α-aminoamides, α-aminoamidines, indoles and diiminoazetidines. The reaction ...

    Developmental toxicity screening in the zebrafish embryo – a metabolomics approach 

    Wilhelmi, Pia Rosa Maria (Date of defense: 2024-07-19)

    [eng] Birth defects occur in about 3-6% of human births worldwide (CDC, 2023). To mitigate the risk to the unborn child, the assessment of embryo-fetal developmental toxicity is an integral part of chemical registration ...

    El déficit cognitivo y la enfermedad de Alzheimer en presencia de alteraciones metabólicas: Estudio in vivo de una nueva diana terapéutica y de la estrategia multidiana para el tratamiento de estas condiciones 

    Espinosa Jiménez, Triana (Date of defense: 2023-09-26)

    [spa] La enfermedad de Alzheimer (EA) es el tipo de demencia más común. En los últimos años su prevalencia se ha incrementado preocupantemente, considerándose la epidemia del siglo XXI. Hasta ahora solo se han conseguido ...

    Efectes metabòlics, vasculars i cognitius del consum de sucres simples en rates femella 

    Sangüesa Puigventós, Gemma (Date of defense: 2017-04-18)

    En les últimes dècades, l’increment del consum de sucres, especialment de fructosa, s’ha associat al desenvolupament de la obesitat i d’alteracions metabòliques com ara diabetis, hipertensió i malalties cardiovasculars. ...

    Enantio- and Diastereoselective Cyclocondensation Reactions. Stereocontrolled Access to Azabicycles and Application to Natural Product Synthesis 

    Ghirardi, Elena (Date of defense: 2016-07-28)

    The first objective of this Thesis was the study of the preparation of octhydro-1H-cyclopenta[b]pyridines and octahydro-1H-indoles, through the synthesis of (R)-phenylglycinol derived tricyclic lactams. Following the ...

    Estudio de los efectos en el neurodesarrollo de productos a base de plantas (PBPs) consumidos por la población gestante y lactante usando el modelo del pez cebra 

    Romero, Noelia Giselle (Date of defense: 2025-04-08)

    [spa] A nivel mundial, el uso de productos a base de plantas (PBPs) entre las mujeres durante el embarazo y la lactancia se estima en un 60% en los países occidentales y 76% en países orientales, pero no hay datos sobre ...

    From the design to the in vivo evaluation of novel soluble epoxide hydrolase inhibitors 

    Codony Gisbert, Sandra (Date of defense: 2020-09-17)

    Epoxieicosatrienoic acids acids (EETs) are endogenous chemical mediators derived from arachidonic acid that show anti-inflammatory, antihypertensive, analgesic, angiogenic and antiatherosclerotic effects. Soluble epoxide ...

    Mecanismos implicados en la neurodegeneración inducida por dieta grasa en modelos de senescencia 

    Palomera Ávalos, Verónica (Date of defense: 2018-01-26)

    La población mundial está envejeciendo, la mayoría de países del mundo están experimentando un aumento en el número y la proporción de personas mayores. Los últimos datos publicados de la ONU en 2017 informan que se espera ...

    Multi-functionalization of micro- and nanoparticles for cancer theranostics 

    Amirthalingam, Ezhil (Date of defense: 2018-10-01)

    This thesis has its main focus on developing multi-functional nanomaterials, that we called nano- and microtools through two different approaches, top-down to provide support and bottom up to give functionality to prepare ...

    Multitarget strategies in search of novel drug candidates against Alzheimer’s disease 

    Pont Masanet, Caterina (Date of defense: 2020-01-31)

    Alzheimer’s disease (AD) is the most common form of dementia and one of the most important health-care problems in the world, due to its high prevalence and unaffordable personal and economic impact. Moreover, current ...

    New polycyclic small molecules as ion channel modulators 

    Barniol Xicota, Marta (Date of defense: 2017-01-13)

    L’objectiu de la present tesi doctoral consisteix en desenvolupar molècules policícliques de baix pes molecular que tinguin com a diana tres canals iònics específics: la viroporina A/M2 del virus de la grip, el receptor ...

    Novel approaches toward anti-Alzheimer and antiprotozoal drug candidates 

    Sola Lao, Irene (Date of defense: 2016-11-15)

    This PhD Thesis pursues the development of novel anti-Alzheimer and antiprotozoal drug candidates upon exploitation of three different novel approaches: Multitarget therapies, Drug repurposing, and Validation of a novel ...

    Novel multi-target directed ligands as drug candidates against Alzheimer’s disease 

    Pérez Areales, Francisco Javier (Date of defense: 2017-07-14)

    Alzheimer’s disease (AD) is the main neurodegenerative disorder and one of the most important health-care problems worldwide, because of its high prevalence and personal and economic impact. To aggravate this situation, ...

    Novel potential determinants in endoplasmic reticulum stress, inflammation and insulin resistance: Apo CIII and sAPPβ 

    Botteri, Gaia (Date of defense: 2018-03-14)

    Diabetes represents one of the biggest health challenges of the 21st century. Insulin resistance is the primary defect in the most common form of diabetes, type 2 diabetes mellitus (T2D), and is defined as a failure in the ...