Universitat de Barcelona
Now showing items 21-40 of 85
Carbohydrates are one of the most important biochemical molecules due to their role as energetic resource for non-photosynthetic organisms, cell-cell recognition and adhesion, protection of cell membranes of bacteria and ...
L'objectiu principal d'aquesta Tesi doctoral ha estat l’obtenció d’una via alternativa a les existents per a l'obtenció d'un intermedi clau, 1, en la síntesi d'un fàrmac anticoagulant. La nova via havia de ser novedosa i ...
c-Src is a central player in several cellular signaling pathways. It controls impor- tant cellular processes like cellular proliferation, survival or motility. Therefore, a number of tumoral diseases have been related to ...
The Thesis is based on the development of a potentially-scalable methodology to prepare polyurethane/polyurea polymers to nanoencapsulate bioactive molecules. In the first part of the project, the design, optimization and ...
The discovery of cisplatin and its successful use as chemotherapeutic agent have encouraged the development of metal-based anticancer molecules. The present doctoral research project includes three different chemistry ...
Nowadays, serious concern exists about atmospheric CO2 increase related with environmental impact and climate change. The reuse of CO2 through its chemical recycling is a promising route, which could contribute to the ...
Amb l’objectiu d’obtenir materials moleculars amb una o més propietats físiques tals com magnètiques, luminescents i/o quirals en aquest treball s’han obtingut nous compostos de coordinació basats en metalls de transició, ...
Enzymes have attracted the attention of chemists and biologists since long ago due to their molecular complexity and tremendous efficiency. They are highly specific catalysts that make chemical reactions possible at mild ...
El siguiente trabajo recopila los resultados conseguidos durante el transcurso del periodo Doctoral, el cual se divide en dos secciones: la primera sección aborda distintos estudios sobre reacciones organocatalíticas, ...
El desarrollo de métodos para la creación de nuevos enlaces carbono-carbono de forma sostenible y selectiva es clave en la química orgánica actual. En las últimas décadas, ha aumentado de gran manera el interés en llevar ...
Les nanopartícules de metalls nobles han atret l’interès dels investigadors en els últims anys degut a la seva elevada activitat i selectivitat en un gran nombre de reaccions catalítiques. No obstant això, les nanopartícules ...
Estudios previos de nuestro grupo de investigación describieron moléculas orgánicas heterocíclicas, aparentemente de capas cerradas que presentan carácter birradical triplete asequible térmicamente. La formación de esta ...
Nanoscience and Nanotechnology have become research areas that promote the design and fabrication of novel devices with a number of different applications with the aim of satisfying the growing demand of the society regarding ...
Asymmetric hydrogenation of double bonds by means of organometallic catalysis is a powerful tool for organic synthesis; it is an efficient and simple method to produce valued chiral compounds. Among the many different ...
Matrix metalloproteinases (MMPs) are a family of zinc-containing endopeptidases involved in the degradation of the extracellular matrix. They make a major contribution to the progression of a vast number of diseases, ...
Somatostatin (SST or SRIF14) is a peptidic hormone secreted throughout the central nervous system and in the gastrointestinal tract which has anti-secretory, anti-proliferative and anti-angiogenic effects. Although its ...
In the present Thesis, it has been carried out the development of new chemical tools for the diagnosis and treatment of cancer through the use of light as an external factor. On the one hand, light can be used to control, ...
Combining the judiciously designed bis−β-diketone and polypyrazolyl scaffolds with the crystal field effects on the 3d metal ions, this manuscript exposes different methods of selective preparation of new heterometallic ...
During this doctoral thesis, we have synthesised hundreds of grams of the TGF-β inhibitor LY2157299 (Galunisertib). This product was used by the group of Eduard Batlle in their investigations into the roles that TGF-β plays ...
In the present Thesis we continued a previous study of the nucleophilic character of titanium(IV) enolates. Particularly,we focused our attention on the analysis of substrate-controlled Michael additions to enones and other ...
