Recent Submissions

Genetic diagnosis of inherited arrhythmogenic syndromes and sudden cardiac death in pediatrics 

Martínez-Barrios, Estefanía (Date of defense: 2025-07-08)

ENG- Sudden death in children and young people is rare, but when it occurs, it is a devastating event. In many of these cases, even after a complete autopsy, the exact cause of death cannot be identified. Current evidence ...

Physical exercise-induced health benefits: the potential role of exerkine secretion and epigenetic modifications 

Vasileva, Fidanka (Date of defense: 2025-07-07)

ENG- The thesis findings indicate a more favorable cardio-metabolic profile in children who are more physically active, as compared to less physically active ones (Study 1). Interestingly, the current findings suggest that ...

Optimització del procés de tractament actual dels pacients amb tumors localment avançats de laringe/hipofaringe: validació de factors pronòstics clínics de preservació d’òrgan i processament volumètric en la delimitació dels volums de tractament radioteràpic 

Marruecos Querol, Jordi (Date of defense: 2025-07-07)

ENG- This study analyzes the treatment of locally advanced laryngeal and hypopharyngeal tumors, focusing on two key areas: the validation of the TALK protocol and the use of the Smoothing tool in radiotherapy. - Validation ...

MALDI-TOF spectral fingerprints analysis by Artificial Neural Networks of different types of pathological pain in experimental models 

Deulofeu, Meritxell (Date of defense: 2019-12-13)

ENG- Pathological pain is a complex and widely prevalent disease in our society. This type of pain can be divided into two different types: neuropathic pain, which is caused by nervous system injuries (e.g. nerve and spinal ...

Tratamiento farmacológico del dolor en dos modelos experimentales de fibromialgia en ratón 

Álvarez-Pérez, Beltrán (Date of defense: 2019-12-09)

ENG- Fibromyalgia syndrome is a chronic disease that presents chronic diffuse musculoskeletal pain combined with fatigue, sleep alterations and cognitive alterations. Currently, about 2.3% of the world's population suffers ...

Role of sigma-1 receptor in central neuropathic pain development after mild spinal cord injury in mice 

Castany Quintana, Sílvia (Date of defense: 2017-10-27)

ENG- The traumatic injury of the spinal cord causes the onset of pain in 65% of patients. Almost 50% of them do not respond to current analgesic treatments. It is a serious health condition with considerable impact on ...

The impact of imprinted genes on growth and cardiometabolic risk parameters in healthy children 

Mas Parés, Berta (Date of defense: 2025-04-07)

ENG- Imprinted genes are expressed only from one parental allele, either from the mother or the father. They play fundamental roles in fetal and placental growth, as well as in neurobehavioral traits. These genes are ...

Abordaje laparoscópico 3D de la patología suprarrenal 

Ranea Goñi, Alejandro Andrés (Date of defense: 2025-03-21)

ENG- Introduction: Laparoscopic adrenalectomy, introduced in the 1990s, replaced open surgery as the gold standard. While advantageous, 2D vision has limitations in depth perception, addressed by 3D systems. This study ...

A comprehensive approach to meeting the needs and demands of people with multiple sclerosis 

Robles Sánchez, Miguel Ángel (Date of defense: 2025-02-28)

ENG- This thesis aims to provide a comprehensive approach to meeting the needs and demands of people with multiple sclerosis (MS) by expanding knowledge and offering solutions to enhance patient participation, health ...

Analysis of microbiota patterns linked to pancreatic cancer and their role in host inflammation, oxidative stress, and immune status 

Vilà-Quintana, Laura (Date of defense: 2025-02-07)

ENG- Pancreatic cancer (PDAC) is becoming more common, especially in developed countries, due to risk factors like smoking and alcohol-related chronic pancreatitis (CP). Its hidden location often causes late-stage diagnosis, ...

Desenvolupament i implementació clínica d’un nou dispositiu en tècniques d’inspiració forçada mantinguda en tractaments de càncer de mama esquerra amb radioteràpia externa per reduir la dosi al cor 

Romera Martínez, Ingrid (Date of defense: 2024-12-05)

ENG- The radiotherapy treatment for left breast cancer is widely described. One of the long-term undesirable effects of radiotherapy is heart disease, which often manifests as ischemia or myocardial infarction, especially ...

L’elastografia ecogràfica per avaluar l’elasticitat muscular en els infants amb paràlisi cerebral 

Casellas-Vidal, Dolors (Date of defense: 2024-11-27)

ENG- Introduction: Children with spastic cerebral palsy (CP) suffer from biomechanical changes in their muscles, causing excessive spasticity. These changes in muscle tone can be estimated by means of clinical scales or ...

Estudi de la malaltia ateroscleròtica subclínica en pacients amb diabetis tipus 1 de la regió sanitària de Girona 

Sojo Vega, Lidia (Date of defense: 2024-12-02)

ENG- Cardiovascular diseases (CVDs) are the leading cause of death and illness in people with type 1 diabetes (T1D). However, the traditional prediction models for cardiovascular events, which are based on common risk ...

TGFβI gene promoter methylation as a biomarker of resistance to anti-HER2 therapies in HER2-positive breast cancer 

Pla-Juher, Helena (Date of defense: 2024-12-02)

ENG- HER2 positive breast cancer represents approximately 15-20% of breast cancer and it is associated with higher grade, more aggressive phenotype and worse prognosis. The prognosis of these patients has dramatically ...

Unravelling the relevance of Plakophilin-2 and Olfactomedin-2 in obesity 

Lluch Balaña, Aina (Date of defense: 2024-10-22)

ENG- Obesity is a complex chronic disease linked to adipocyte dysfunction and a low-grade inflammatory condition leading to the impaired synthetic and secretory activity of hyperplastic depots of adipose tissue. As a ...

New insights in the study of the physiology of the adipose tissue 

Oliveras-Cañellas, Núria (Date of defense: 2024-10-09)

ENG- The prevalence of obesity has increased dramatically in recent years and has reached epidemic proportions. Obesity is a chronic multifactorial disease associated with an abnormal accumulation of dysfunctional adipose ...

Identificación y caracterización de nuevos biomarcadores para el diagnóstico de la miocardiopatía dilatada 

Perez-Serra, Alexandra (Date of defense: 2024-10-18)

ENG- Atherosclerotic cardiovascular diseases are efficiently treated with statins. These medications can cause unwanted muscle problems in some patients, leading them to discontinue treatment. In this context, the ...

Impact of serum ferritin and metformin on cognitive function in middle-aged subjects: modulation by the gut microbiome 

Rosell Díaz , Marisel (Date of defense: 2024-10-07)

ENG- The global obesity epidemic represents a major threat to public health worldwide. Obesity is associated with many complications that reduce quality of life and longevity. Complications associated with obesity include ...

Fenotipado de las mutaciones NRAS en cáncer colorrectal: caracterización clínico-molecular y búsqueda de nuevas terapias 

Queralt, Bernardo (Date of defense: 2024-09-30)

ENG- Metastatic colorectal cancer (mCRC) remains a major medical challenge, particularly in the search for effective treatments such as epidermal growth factor receptor (EGFR)-targeted therapies. While mutations in the ...

Fatty acids profile and DNA methylation in the placenta: prevention of cardiometabolic risk and obesity in childhood 

Gómez-Vilarrubla, Ariadna (Date of defense: 2024-07-24)

ENG- The increase in the prevalence of obesity worldwide over the past 50 years has led to obesity being considered the pandemic of the 21st century. Overweight and obesity are under scrutiny because the current pediatric ...