Now showing items 77-96 of 457

    Cálculo médico legal de un índice de peligrosidad 

    Saumench Gimeno, Domingo (Date of defense: 1960-01-01)

    Extractos de la Introducción de la tesis: El concepto de peligrosidad es en esencia jurídico y se debe a la Escuela Positivista italiana. El considerar al delincuenta como una personalidad en la cual el delito es fatal, ...

    Cell-enriched engineered cardiac grafts improve heart function and promote cardiac regeneration: a novel therapy for myocardial infarction 

    Perea Gil, Isaac (Date of defense: 2017-07-03)

    El infarto de miocardio es una de las enfermedades cardiovasculares de mayor incidencia y mortalidad entre la población mundial. A pesar de los diferentes tratamientos empleados, a día de hoy ninguno de ellos consigue ...

    Cervical cancer and pre-cancer in the EPIC cohort: the role of environmental cofactors = El càncer de coll uterí i els seus precursos en la cohort EPIC: el rol dels cofactors ambientals 

    Roura Fornells, Esther (Date of defense: 2018-10-22)

    The objective of this thesis is to estimate prospectively the association between environmental cofactors and the risk of developing cervical cancer and pre-cancer, including tobacco smoking, hormonal and reproductive ...

    Characterization and prevention of the “small-for-size” syndrome in a porcine model of hepatic transplant 

    Hessheimer, Amelia Judith (Date of defense: 2011-04-13)

    The hypothesis of this doctoral thesis is two-fold: 1. Excessive portal vein flow is present immediately after portal reperfusion in the recipient and is the instigating factors in a series of events that ultimately ...

    Characterization of heart failure with preserved ejection fraction in the outpatient setting: improvement in prognosis assessment and applicability of new echocardiographic techniques 

    Sanchis Ruiz, Laura (Date of defense: 2016-10-20)

    Heart failure with preserved left ventricular ejection fraction (HFPEF) is the most prevalent type of heart failure (HF) in the outpatient setting. Left ventricular ejection fraction values (considered as a surrogate of ...

    Characterization of novel actionable molecular subgroups in Hepatocellular Carcinoma: Immune class and IGF2-driven tumors 

    Martínez Quetglas, Iris (Date of defense: 2018-01-09)

    Insulin-like growth factor (IGF) signaling is frequently altered in HCC, including activation of IGF1R, IGF2 overexpression, IGFBP3 downregulation and IGF2R allelic losses1,2. A previous study from our group identified ...

    Characterization of the DNA methylation patterns of chemosensitive and chemoresistant human cancer cells: Biological and clinical impact 

    Moutinho, Cátia (Date of defense: 2014-05-23)

    Although chemotherapeutic drugs are widely used in order to improve the cancer outcome, drug resistance remain the most unpredictable factor affecting chemotherapy and a major impediment to successful patient’s treatment. ...

    Characterization of the pulmonary and systemic immune response in relation with lung stem cells in patients with COPD 

    Cruz Santa Cruz, Tamara (Date of defense: 2017-07-21)

    RATIONALE: Chronic obstructive pulmonary disease (COPD) is characterized by chronic airflow limitation caused by a combination of airways disease (bronchiolitis) and parenchymal destruction (emphysema), whose relative ...

    Characterization of the spectrum of cardiac adaptation to endurance exercise: Impact of gender and training load 

    Sanz de la Garza, María (Date of defense: 2017-05-05)

    The beneficial impact of regular physical activity on cardiovascular health is well established. However, the ideal amount of exercise required to provide these benefits is not well defined, with some recent reports showing ...

    Cierre percutáneo de la orejuela izquierda: eficacia, seguridad y nuevas perspectivas 

    Freixa Rofastes, Xavier (Date of defense: 2015-11-27)

    Esta tesis, presentada como compendio de publicaciones, estudia diversos aspectos relacionados con el cierre percutáneo de orejuela izquierda. Está técnica, de reciente introducción, permite mantener la protección frente ...

    Clinical approach and management of bacterial infections of the central nervous system related to hydrocephalus 

    Pelegrín Senent, Iván (Date of defense: 2017-06-30)

    INTRODUCTION: Community-acquired bacterial meningitis is a relevant entity related to a high morbidity and mortality, despite of the adjuvant and antibiotic treatments available. Morbidity and mortality are caused by ...

    Combination of cytotoxic agents and targeted therapy for the treatment of advanced sarcomas: preclinical background and early clinical development 

    Martín Liberal, Juan Jesús (Date of defense: 2016-11-07)

    Sarcomas are a group of malignancies characterized by their bad prognosis and the absence of effective treatments. Median survival of advanced sarcoma patients is only one year in spite of treatment. Therefore, it is ...

    Combined Therapies for Neuroblastoma Based on the Activation of the Calcium- Sensing Receptor 

    Gonçalves Alves, Eliana Carolina (Date of defense: 2021-01-15)

    [eng] Neuroblastoma (NB) is the most common extracranial solid childhood tumour. Its clinical and histological manifestations range from benign tumours that spontaneously regress to highly aggressive metastatic tumours ...

    Comprehensive Molecular Characterization of Childhood Liver Cancer: Identification of Prognostic Biomarkers 

    Simon Coma, Marina (Date of defense: 2017-12-14)

    Malignant tumors in children and adolescents are one of the leading causes of death from disease in this population despite being rare events. The main liver tumor in children is Hepatoblastoma (HB) representing two thirds ...

    Computational analysis of schizophrenia: Implementation of a multivariate model of anatomical differences 

    Monté Rubio, Gemma C. (Date of defense: 2015-12-17)

    Chronic schizophrenia has been widely studied, consistent findings have shown the anatomical pattern associated with this disease, but the clinical picture is often undifferentiated at first presentation. Finding morphometric ...

    Computational Intelligence Techniques for Electro-Physiological Data Analysis 

    Riera Sardà, Alexandre (Date of defense: 2012-11-09)

    This work contains the efforts I have made in the last years in the field of Electrophysiological data analysis. Most of the work has been done at Starlab Barcelona S.L. and part of it at the Neurodynamics Laboratory of ...

    Condensin complex and Molecular Motor KIF4A, new players in CRC under WNT signalling regulation = Papel del Complejo Condensina y el Motor Molecular KIF4A en el Cáncer Colorrectal como nuevas dianas de la vía de señalización Wnt 

    Súarez López, Lucía (Date of defense: 2013-07-05)

    Durante la división celular, el ADN debe estructurarse en cromosomas para asegurar un correcto reparto de la información genética a las dos células hijas. El complejo condensina, junto con el motor molecular KIF4A, son los ...

    Connecting RAGE and cell plasticity in triple-negative breast cancer 

    Pujals Pruneda, Mireia (Date of defense: 2022-03-01)

    RAGE is a transmembrane protein of the immunoglobulin family highly expressed during embryonic development but rarely expressed in adult healthy tissues. However, under cellular stress RAGE is re-expressed and mediates ...

    Contribución de la anemia y de la exposición al virus de la inmunodeficiencia humana a la morbi-mortalidad infantil en África 

    Moraleda Redecilla, Cinta (Date of defense: 2015-04-15)

    INTRODUCCIÓN Cada año mueren en el mundo más de 6 millones de niños menores de 5 años. Cerca del 50% en África subsahariana. Mejorar el conocimiento de patologías como la anemia y la exposición perinatal al VIH, que ...

    Control of integrin-mediated mechanoresponse by binding partners and force loading rates 

    González Tarragó, Víctor (Date of defense: 2019-07-11)

    This thesis is a study on the integrin-mediated mechanoresponse by binding partners and force loading rates. Regarding the binding partners, here we demonstrate an alternative and counter-intuitive mechanism, by which ...