Now showing items 416-435 of 457

    Study of the expression and regulation of the autocrine loop components of the cyclooxygenase pathway and their implication in aspirin exacerbated respiratory disease 

    Machado de Carvalho, Liliana Sofia (Date of defense: 2015-11-27)

    Aspirin exacerbated respiratory disease (AERD) is a clinical syndrome characterized by the combination of nasal polyps (NPs), chronic hypertrophic eosinophilic sinusitis, asthma and severity to any medication that inhibits ...

    Surgical Assessment of Insular Gliomas: Operative Technique and Clinical Outcomes 

    Benet Cabero, Arnau (Date of defense: 2020-11-09)

    BACKGROUND: Surgical treatment of Insular gliomas is technically challenging and may lead to high postoperative morbidity. However, previous research has proven that maximal safe resection is critical for ...

    Susceptibilidad a Melanoma: nuevos aspectos clínico-patológicos, desarrollo de herramientas y modelos de estudio y evaluación de medidas preventivas 

    Aguilera Peiró, Paula (Date of defense: 2015-09-23)

    El trabajo contenido en esta Tesis Doctoral ha ido encaminado a mejorar el conocimiento del Melanoma Familiar con el fin de mejorar su prevención y tratamiento. En el primero de los trabajos publicados se han descrito y ...

    Susceptibilidad genética al cáncer gástrico y lesiones precursoras, y mecanismos moleculares que intervienen en la progresión de la metaplasia intestinal 

    Companioni Nápoles, Osmel (Date of defense: 2015-10-26)

    El cáncer gástrico es el resultado de sucesivos cambios histológicos en la mucosa gástrica conocidos como lesiones preneoplásicas y cuya sucesión es conocida como la Cascada de Correa, constituyendo el mecanismo de ...

    Synaptic and non-synaptic propagation of slow waves and their modulation by endogenous electric fields 

    Rebollo González, Beatriz (Date of defense: 2017-06-14)

    The cerebral cortex is organized in complex circuits of neurons strongly interconnected in a conductive medium. During deep sleep stage, this neuronal connectivity generates recurrent synchronized synaptic activity leading ...

    Synthesis and biological function of fucose in Plasmodium falciparum 

    Sanz Sender, Silvia (Date of defense: 2017-04-28)

    Malaria is a parasitic disease caused by Plasmodium parasites and it is transmitted by female Anopheles mosquito. P. falciparum has a complex life cycle that includes important stages in two different hosts: a mosquito and ...

    A Systems Medicine approach to multimorbidity. Towards personalised care for patients with Chronic Obstructive Pulmonary Disease 

    Tényi, Ákos (Date of defense: 2018-07-13)

    BACKGROUND: Multimorbidity (i.e. the presence of more than one chronic disease in the same patient) and comorbidity (i.e. the presence of more than one chronic disease in the presence of an index disease) are main sources ...

    Target Therapy in Rhabdomyosarcoma: Discovering new targets and apportunities 

    Prada Varela, Estela Maria (Date of defense: 2021-11-05)

    Pediatric RMS is a developmental tumor that affects patients from birth to late adolescence. RMS tumorigenesis involves the stalk of embryological myogenic processes. Classically, two main subgroups of RMS have been defined ...

    Targeted therapies in CLL. New drugs against CLL recurrent mutations 

    Giménez Carabaza, Neus (Date of defense: 2019-11-15)

    Chronic lymphocytic leukemia (CLL) is the most common leukemia in the western countries. It is currently an incurable disease. CLL is a B-lymphoid neoplasm in which the microenvironment plays a key role in the development ...

    Targeting Malaria Transmission: A Transdisciplinary Approach 

    Portugaliza, Harvie P. (Date of defense: 2020-12-16)

    To achieve malaria elimination, great emphasis must be put on targeting the parasite’s transmissible stages, so that along with effective treatment of clinical malaria caused by asexual stages, complete interruption of the ...

    Targeting the crosstalk between tumor cells and microenvironment: a new therapeutic approach for the treatment of lymphoid neoplasms 

    Vidal Crespo, Anna (Date of defense: 2017-04-28)

    In this thesis we have focused on two novel therapeutic strategies that target the crosstalk between the tumor cells and the microenvironment. Chronic lymphocytic leukemia (CLL) remains an incurable disease where high ...

    Targeting tumor microenvironment crosstalk through GPCR receptors and PI3K pathway 

    Guerrero Hernández, Martina (Date of defense: 2019-02-19)

    The tumor microenvironment (TME) is gaining momentum due to its contribution to cancer progression and therapy resistance. This TME has a direct crosstalk with tumor cells that involves the activation of different ...

    Tatuaje y delincuencia 

    Font Riera, Gabriel (Date of defense: 1971-01-01)

    Por el nacimiento y habitual radicación en las Islas Baleares, y en tanto cursamos los estudios preuniversitarios. permitió que durante varios años llamara poderosamente nuestra atención el observar en innumerables ...

    Temperamento y carácter en trastornos de la conducta alimentaria: correlatos clínicos, psicopatológicos y terapéuticos 

    Agüera, Zaida (Date of defense: 2013-12-12)

    Los Trastornos de la Conducta Alimentaria (TCA) son enfermedades mentales complejas en las que convergen numerosos de factores de riesgo y mantenimiento. La literatura previa pone de relieve la importancia de los rasgos ...

    Teràpia gènica amb hHGF en models de dany renal 

    Franquesa Bartolomé, Marcela (Date of defense: 2010-01-15)

    La isquèmia renal és una de les principals causes del Fracas Renal Agut i en el context del trasplantament renal predisposa l’òrgan a un dany crònic i a una possible pèrdua de l’empelt. La cèl•lula epitelial tubular ...

    The association of DNA methylation patterns in TCF7L2 and GIPR genes with Type 2 Diabetes 

    Canivell Fusté, Silvia (Date of defense: 2014-10-14)

    The incidence of type 2 diabetes mellitus (T2D) is increasing worldwide. There are several explanations to this fact, such as the increased prevalence of obesity, population’s ageing, and the lack of physical activity ...

    The dynamics of emotional and cognitive networks: Graph-based analysis of brain networks using fMRI and theoretical model for cingulo-frontal network dynamics in major depression 

    Ramírez Mahaluf, Juan Pablo (Date of defense: 2015-05-14)

    This thesis is composed of two complementary projects. One focuses on the study of the dynamics between emotional and cognitive networks in healthy subjects using functional magnetic resonance imaging (fMRI). The second ...

    The epidemiology of diarrhea: Determination of the burden, etiology and consequences of diarrheal disease in children aged 0-59 months in Manhiça District, Mozambique = La epidemiología de las diarreas: Determinación del peso, etiología y secuelas de la enfermedad diarreica en niños de 0-59 meses de edad en el Distrito de Manhiça, Mozambique 

    Nhampossa, Tacilta Helena Francisco (Date of defense: 2013-12-20)

    The objective of this thesis is to improve our understanding of the epidemiology of diarrhea, particularly to estimate the population-based burden, microbiologic etiology and adverse clinical consequences of moderate-to-severe ...

    The possible link between high glucose-induced PKCβ expression and the appearance of GLP-1 resistance in endothelial cells 

    De Nigris, Valeria (Date of defense: 2015-12-03)

    INTRODUCTION. It has been demonstrated that Glucagon-like peptide-1 (GPL-1) has a protective effect on endothelial cells. GLP-1 improves endothelial function in diabetes, however the mechanisms underlying the GLP-1 protective ...

    The role of cyclin-dependent kinase 5 (Cdk5) in colorectal cancer 

    Kjaergaard Bystrup, Sara (Date of defense: 2021-07-20)

    [cat] El càncer colorectal (CCR) és el tercer càncer més freqüent en homes i el segon en dones a nivell mundial. Tot i que les taxes de supervivència a 5 anys en els primers estadis superen el 90%, la situació canvia ...