Universitat Pompeu Fabra: Recent submissions
Now showing items 26-45 of 3213
Uncertainty analysis of individual predictions and integrated safety assessments in toxicology
The growing importance of uncertainty analysis in toxicology stems from its role in supporting regulatory decisions regarding chemical safety. The general objective of this thesis is to identify gaps in state-of-the- art ...
Inhaled treatment and patient-reported outcomes in asthma
The general aim of this doctoral thesis was to examine the impact on persons with persistent asthma of inhaled treatment use and sociodemographic factors, in terms of patient-reported outcomes. To achieve this, a new ...
Characterization of synthetic lethality between MYC activation and splicing inhibition in an immortalized cell line : roles of alternative splicing
Cancer cells exhibit a synthetic lethal (SL) phenotype when Myc upregulation is combined with antitumor drugs targeting the splicing factor SF3B1. However, the molecular events and mechanisms responsible for this vulnerability ...
The Hajar Mountains of Southeastern Arabia: a laboratory to understand how reptile diversity is generated, distributed and maintained in arid environments
This thesis provides new insights into the evolution of biodiversity in arid regions by exploring the patterns and drivers of reptile diversity in the Hajar Mountains of Southeastern Arabia. We first assemble a genomic ...
Exploring the frontiers of synthetic biology: modelling, characterization, and applications of genetics circuits
Engineering biology requires a clear set of rules that ensure design predictability. However, certain biological processes difficult the application of these rules, impairing prediction. In the first section of this PhD ...
The price of deciding: balancing resource constraints for optimisation
Prendre decisions es un repte, i a la par un aspecte inevitable a les nostres vides. D’entre totes les opcions viables, hom ha de sotmetre a escrutini i avaluació les diverses alternatives en tant gestionant la frustració ...
Adaptations in cancer: a molecular and mechanistic rewiring
Cancer cells are constantly subject to complex stresses in the tumour microenvironment. These stresses encapsulate a wide array of challenging stimuli from physical and mechanical forces to interference in major mechanistic ...
Temporal resolution by multiomic approaches of acute myeloid leukemias
Acute myeloid leukemias (AMLs) are a type of cancer where undifferentiated myeloid cells abnormally proliferate. Such phenotype can be caused by the expression of chimeric proteins like PML-RARα and MLL-AF9. Many studies ...
Understanding the molecular basis of neuronal 3'UTR length-dependent mRNA sorting
The local translation of messenger RNAs (mRNAs) within different neuronal compartments is a prerequisite the formation of long-term memories. mRNAs are localized via active transport along microtubules, however, the ...
Integration of genetic and chemical screens to discover targeted therapies for HNF1 A-deficient diabetes
HNF1A encodes a key transcription factor in insulin-secreting beta cells from pancreatic islets. Heterozygous mutations in HNF1A cause monogenic diabetes, and hypomorphic variants in HNF1A increase the risk for type 2 ...
Mitochondria-to-cytosol H2O2 fluxes in redox biology
Los efectos del H2O2 en la fisiología celular, como oxidante y como señalizador es un campo que aún esta en expansión. Para intentar desvelar como ocurren estos fenómenos, hemos utilizado sondas codificadas genéticamente ...
Long-term resilience of cultivation systems in Tigrai (Ethiopia): an integrated approach combining archaeobotany, ethnoarchaeology and ecological modelling
The present study expands our understanding of human-environment interactions in drylands throughout time, with a specific focus on the development of resilient agroecological systems based on Traditional Ecological ...
Poéticas opositivas del tardofranquismo: Una crítica histórica de las poéticas de Juan Benet, Rafael Sánchez Ferlosio, Carmen Martín Gaite, Juan Goytisolo y Manuel Vázquez Montalbán
El objetivo de esta investigación es describir y analizar como un fenómeno de conjunto el emerger de las reflexiones sobre el hecho literario que Juan Benet, Rafael Sánchez Ferlosio, Carmen Martín Gaite, Juan Goytisolo y ...
Corporeidades al límite: El cuerpo femenino como territorio fronterizo desde la práctica artística como investigación
En Corporeidades al límite. El cuerpo femenino como territorio fronterizo desde la práctica artística como investigación, planteo una aproximación teórico-práctica de la presentación y representación del cuerpo femenino ...
Los bastiones del Rey, el camino de la Patria: Guerra, control y pacificación en el Camino Real de Veracruz, 1762-1821
This proposal focuses on the study of the military roads implemented by the viceregal government after 1815, in the different segments of the Camino Real during the Mexican War of Independence. From this perspective, ...
Climate change, migration, and corrective duties: Thinking beyond sinking islands
The philosophical discussion on climate change and migration to date has focused mainly on the case ‘sinking islands’. Though critical, this case represents only a small fraction of the empirical and normative landscape ...
Constitucionalismo deliberativo: Objeciones a la jurisdicción constitucional y democracia deliberativa
El constitucionalismo fuerte, hoy prevaleciente a nivel global, fue puesto en tela de juicio desde sus orígenes, pero hay dos circunstancias que han agudizado dicho cuestionamiento. Por un lado, las crecientes y más ...
The Value of Values: A critical assessmet of citizenship by investment programs in the European Union
The primary objective of this doctoral dissertation is to examine the phenomenon of citizenship by investment programs (CIPs) thoroughly by analyzing the existing programs within the European Union (EU) as of 2018. ...
The Internatinoal authoritiy of the International Court of Justice: International adjudication in the Asia-Pacific region
The main objective of this dissertation is to analyze the international authority of the International Court of Justice in the Asia-Pacific region against a scenario of redistribution of power and potential shifts in ...
Productores libres e iguales: Trabajo y democracia en la teoría republicana
This thesis uses republican political philosophy to analyse several central labour issues, propose institutional responses to the problems addressed and discuss which conceptual tools are necessary to understand them. I ...
