Kurtz, Katryn Lucille (Date of defense: 2008-12-12)
The study of chromatin structure in several simple sperm models of increasing complexity was performed. Species demonstrating different types of sperm nuclear protein transitions and structural changes ...
González Franquesa, Alba (Date of defense: 2015-12-18)
Type 2 Diabetes Mellitus (T2DM) is the metabolic disorder that accounts for the presence of hyperglycemia within insulin resistance (IR). The International Diabetes Federation estimated in 2013 that 382 ...
Rodilla Benito, Verónica (Date of defense: 2011-05-13)
Colorectal tumors with mutations on Wnt family members show an overexpression of several Notch target genes, suggesting a link between Wnt and Notch signaling pathways. In this work, we have ...
Rubio Patiño, Camila (Date of defense: 2012-10-31)
Glucocorticoids (GC) induce cell cycle arrest and apoptosis in different cell types and therefore are widely used to treat a variety of diseases including autoimmune disorders and cancer. This effect ...
Alsina Sanchís, Elisenda (Date of defense: 2016-01-21)
Role of TGFβ in physiological angiogenesis and ovarian cancer Transforming Growth Factor Beta (TGFβ) is a signalling pathway involved in a wide range of cellular processes such as proliferation, ...
Moncunill Massaguer, Cristina (Date of defense: 2015-07-23)
The pro-apoptotic effects of two new drugs have been studied for the development of new strategies for cancer treatment. On the one hand, we proved that AICAR induces apoptosis in an AMPK- and p53-independent ...
Gamez Molina, Beatriz (Date of defense: 2015-12-17)
We propose a molecular description of the mechanism whereby the osteogenic master gene Osx is controlled post-transcriptionally through a mechanism driven by miR-322/Tob2, strongly suggesting that control ...