A computational study of intervertebral disc degeneration in relation to changes in regional tissue composition and disc nutrition 

    Ruiz Wills, Carlos (Date of defense: 2015-07-17)

    Up to 85% of the world population suffers from low back pain, a clinical condition often related to the intervertebral disc (IVD) degeneration (DD). Altered disc cell nutrition affects cell viability and can generate ...

    Bone regeneration by tuning the drug release from the calcium phosphate scaffolds 

    Khurana, Kanupriya (Date of defense: 2017-11-10)

    Bone is among the most transplanted tissues for regeneration of bone defects, caused by trauma, age-related bone loss or bone infections. Due to their similar characteristics to the mineral phase of bone, calcium phosphates ...

    Design of hybrid fibers for bone tissue engineering 

    Sachot, Nadège (Date of defense: 2014-07-03)

    Most of the conventional organic-inorganic composite materials developed for bone tissue engineering do not possess intimate interactions between their constituents. As a consequence, they generally degrade in a non-homogeneous ...

    Functionalization of titanium surfaces with TGF-beta inhibitor peptides 

    Sevilla Sánchez, Pablo (Date of defense: 2013-07-16)

    Esta tesis queda enmarcada en el ámbito de los biomateriales metálicos, concretamente en superficies de titanio desarrolladas para la regeneración ósea. Las aplicaciones más habituales del titanio como biomaterial son los ...

    Time dependent flow of biolubricant and suspended particles behavior within total hip replacement 

    Safari, Alaleh (Date of defense: 2017-03-31)

    Total hip replacement (THR) has been one of the most successful surgeries in the 21st century. Ultra-high-molecular-weight-polyethylene (UHMWPE) shows favorable mechanical and tribological properties when used as a bearing ...

    Tuning the biological performance of calcium phosphates through microstructural and chemical modifications 

    Díez Escudero, Anna (Date of defense: 2017-11-13)

    Bone is the most transplanted tissue after blood. As pointed out by the World Health Organization, musculoskeletal diseases can potentially rise as the fourth largest cause of disability within the next years. Unfortunately, ...