Browsing Departament de Bioquímica i Biologia Molecular (Farmàcia) by Title

Now showing items 105-113 of 113

Search for new antiviral compounds using fragment screening methodology

Kaczmarska, Zuzanna (Date of defense: 2014-12-05)

Picornaviridae are among the most diverse and oldest known viral families that include many important pathogens of humans and animals. They are small, icosahedral (+)ssRNA viruses, causing a variety of diseases, such as ...

Síndrome de cáncer de mama y ovario hereditario: Estudio in vitro de variantes BRCA1 y BRCA2 de significado biológico desconocido y búsqueda de nuevos genes responsables de este síndrome

Quiles Vidal, Francisco de Asís (Date of defense: 2016-02-05)

ANTECEDENTES: Entre un 20-25% de pacientes con cáncer de mama y ovario muestran historia familiar de dicha enfermedad. Una porción de estos casos son debidos a mutaciones germinales en genes de predisposición conocidos y ...

Structural and functional analysis of natural protein-based inhibitors and their protease targets

dos Reis Mendes, Soraia Inês (Date of defense: 2022-10-28)

[eng] Several proteases and their antagonistic protein or peptide inhibitors sparked researchers’ interest due to their potential as therapeutic targets. The present thesis, which compiles results obtained in three independent ...

Study of carnitine palmitoyltransferase 1A (CPT1A) in adipose tissue. Effects on obesity, inflammation and insulin resistance

Malandrino, Maria Ida (Date of defense: 2013-10-04)

Current lifestyle with high-energy diets and little exercise is triggering an alarming growth in obesity. Excess of adiposity is leading to severe increase in associated pathologies, such as insulin resistance, type ...

Study of the molecular mechanisms responsible for E2F1-induced Mtorc1 activation

Meo Evoli, Nathalie (Date of defense: 2014-07-07)

The oncogenic properties of E2F1 have been traditionally associated with the role of the oncogene in proliferation, but during the last few years many other functions associated with this family of transcription factors ...

Study of the phosphorylation and activation of the protein kinase NEK9 during mitosis

Bertran Domingo, M. Teresa (Date of defense: 2012-11-29)

Nek9 is a NIMA-related kinase that is phosphorylated in mitosis and a small pool of it (5%) is activated at the centrosomes by a complex mechanism which has remained elusive until now. Nek6 and Nek7 bind to the C-terminal ...

Study of the physiological function of carnitine palmitoyltransferase 1C enzyme

Carrasco Rodríguez, Patricia (Date of defense: 2012-03-16)

Carnitine palmitoyl transferase 1 (CPT1) enzymes catalyze the conversion of long-chain acyl-CoA to acyl-carnitines, thus facilitating the entry of long-chain fatty acids to the mitochondria, where they undergo β-oxidation. ...

Systematic identification and quantification of substrate specificity determinants in human protein kinases = Identificación y cuantificación sistemática de determinantes de la especificidad por sustrato en las proteínas quinasas de humano

Alonso Tarajano, Manuel Alejandro (Date of defense: 2013-10-24)

In human there are 518 protein kinases reported and many of them are involved in several cellular processes and also in important pathologies. Kinases have a diverse specificity for the sequences they phosphorylate, and ...

The structure and function of maize scutellum during early stages of germination

Tnani, Hédia (Date of defense: 2012-07-18)

The embryo in grasses, at grain maturity, comprises the embryonic axis and the scutellum. The scutellum is supposed to be the single cotyledon in the monocotyledoneus embryos and is attached to the embryo axis in the ...