Facultat de Química: Recent submissions
Now showing items 121-130 of 130
Textiles funcionales obtenidos a partir de la incorporación de nanopartículas poliméricas
El objetivo principal de la presente tesis es el diseño de nanopartículas de etilcelulosa para su utilización como vehículos de principios activos o sustancias lipofílicas y su deposición sobre un tejido, con la finalidad ...
Study of the aggregation process of the amyloid beta-protein associated to Alzheimer's disease. Examination of pharmaceutically important small molecules.
Alzheimer’s disease (AD) is a neurodegenerative disorder which major risk factor is age. Current drugs only offer symptomatic alleviation in AD, thus a disease-modifying treatment is urgent. The amyloid-β (Aβ) protein ...
Small molecules for modulating biological targets
CHAPTER 1: Respiratory Infectious Diseases (RID) are diseases affecting the air passages, the bronchi and the lungs. They range from acute infections, such as pneumonia and bronchitis, to chronic conditions such as ...
Formación y caracterización de emulsiones altamente concentradas de betún en agua
El objetivo principal de la presente tesis ha sido la preparación y caracterización de emulsiones bituminosas concentradas y altamente concentradas de betún en agua controlando el tamaño de gota. Las investigaciones y ...
Protease inhibitors as therapeutic agents
Proteases are involved in a high number of diseases, and thus, are relevant targets. For that reason our main goal was the discovery of protease inhibitors as therapeutic agents. We focused our study in four proteases: ...
Novel Disulfide Formation Strategies in Peptide Synthesis
Cysteine (Cys) is a unique amino acid due to its ability to form reversible covalent disulfide bonds. These bonds cause conformational constraints which make peptides or proteins more rigid and stable. In addition, the ...
Chemically synthesized peptide libraries as a new source of BBB-shuttles. Use of Mass Spectrometry for peptide identification and quantification
The blood-brain barrier (888) is a biological barrier that plays a crucial role protecting the brain from neurotoxic agents and regulating the influx and efflux of molecules required for the correct function of this organ. ...
Desenvolupament i aplicació de metodologies analítiques i quimiomètriques per a l’estudi de la contaminació atmosfèrica
En aquesta Tesi s’han estudiat les fonts d’emissió de diversos contaminants atmosfèrics, principalment a l’àrea de Barcelona. Els contaminants estudiats han estat l’òxid de nitrogen (NO), compost tòxic que s’emet en grans ...
Synthesis, Biological Evaluation and Insights into the Mode of Action of Quinoxaline Containing Peptides
Triostins are members of the quinoxaline antibiotic family, together with the "prototypical bisintercalator" echinomycin. These molecules display interesting antitumour activities as they inhibit transcription through ...
Design of multifunctional polymeric nanoparticles for biomedical applications
The general objective of this research was the design of polymeric cationic nanoparticles from nano-emulsions obtained by low-energy methods for biomedical applications. This general objective includes the preparation of ...
