Universitat de Barcelona
Now showing items 1-15 of 15
[spa] La presente Tesis de carácter multidisciplinar se centra en el diseño y síntesis de nuevos derivados de C75 como potenciales agentes antitumorales e inhibidores de la ingesta para el desarrollo de nuevos fármacos ...
[eng] In this doctoral thesis, the design and synthesis of bifunctional molecules that induce the degradation of a target protein in cells are described. The synthesis of molecules capable of inducing the phosphorylation ...
[eng] Protein-protein interactions (PPIs) play a crucial role in the homeostasis of the cells; therefore, they are important therapeutic targets. Typically, the goal in targeting PPIs is to impede them. On the contrary, ...
Modern medical treatments are largely based on the ability of pharmacological drugs to interact with a molecular target in the human body (e.g., receptors) in order to evoke a physiological response. Such targets are ...
[eng] Organic chemistry is recognized for its ability to arrange a limited set of atoms in numerous ways, a quality that is crucial in molecular magnetism. This branch benefits from the adaptability of organic chemistry ...
In the present thesis we have investigated the development of new methodologies for the selective and straightforward chemical modification of Trp amino acid either alone or in peptides. In the first chapter, we have ...
The Immune System (IS) is a complex collection of tissues, organs, cells and molecules to defense the body against threatens. IS is organized into two lines of defense: innate immunity which acts in a non-specific manner ...
Photopharmacology has the main purpose to allow the control of protein activity with light. The most exploited strategy used to achieve this objective is the freely diffusible photopharmacology and it is based in the use ...
Alzheimer’s disease (AD) is the most common form of dementia. It was first described in 1906 by Alois Alzheimer. Later on, in 1984 George Glenner and Colin Masters isolated the amyloid-beta (Aβ) peptide from a human brain ...
Marine natural products (MNPs) are, undoubtedly, highly valuable starting points for drug-development programs. Generally, MNPs show a well-defined spatial orientation that have evolved for thousands of years to interact ...
Peptides are defined as compounds that contain between two and fifty amino acids connected together by amide bonds. Inside our body, peptides are natural biological messengers that play critical roles in human physiology ...
Chemical protein synthesis has become a potent tool for the synthesis of proteins, especially those which are not easily accessed by DNA recombinant methods, such as proteins with posttranslational modifications. The key ...
Triostins are members of the quinoxaline antibiotic family, together with the "prototypical bisintercalator" echinomycin. These molecules display interesting antitumour activities as they inhibit transcription through ...
[eng] Drug discovery is the process by which new drugs are found and developed into the market. Given the scope of this thesis, the term “drug” will refer to small molecules and the term “target” to proteins, otherwise ...
Amyloid-beta peptide (Aβ) is strongly linked to the aetiology of Alzheimer’s disease (AD). Aβ is the main component of the amyloid plaques found in the brain of AD patients, however, Aβ is also present in the brain of ...
