Martínez Gutiérrez, Alfredo (Date of defense: 2019-12-13)
One of the main causal factors of skin aging is ultraviolet radiation as part of sun exposure. This radiation induces many changes at the molecular level that alter the proper function of skin biological ...
Rodón Ahnert, Laura (Date of defense: 2012-11-28)
The TGF-β pathway is currently considered a therapeutic target in advanced tumors, including glioblastoma (GBM), and several anti-TGFβ agents are in clinical trials and have shown promising results .A ...
Khojasteh, Abbas (Date of defense: 2019-11-22)
Rosmarinic acid (RA), an ester of caffeic acid and 3,4-dihydroxyphenyl lactic acid, is widely distributed in the plant kingdom, including Satureja khuzistanica, a threatened Iranian plant species. ...
Novoa Pardo, Eva Maria (Date of defense: 2012-12-20)
Gene translation is a central process in all cells, in which messenger RNA (mRNA) is decoded by the ribosome to produce a specific amino acid chain, that will later fold into an active protein. This ...
Solé i Codina, Laura (Date of defense: 2013-12-13)
Voltage gated potassium channels (Kv) play important roles in different biological process such as generation and propagation of the nerve pulse and the cardiac action potential, promotion of insulin ...
Brenchat Barberà, Àlex (Date of defense: 2012-03-26)
The work showed in this Thesis has been part of the “5-HT7 and neuropathic pain” project in the pharmaceutical company Esteve. Thus, the aim of this Thesis was in line with the goal of the 5-HT7 project ...
Torrealba Sandoval, Débora Alejandra (Date of defense: 2016-06-03)
El mantenimiento de la homeostasis del sistema inmune innato es fundamental, ya que éste debe mantener una respuesta equilibrada frente a los patógenos. En mamíferos, uno de los mecanismos por el cual ...
Angulo Urarte, Ana (Date of defense: 2017-02-24)
Class IA PI3K (PI3K) functions have been widely investigated over the last two decades. PI3K signalling is located at the crossroads of many cell surface receptors sending signals to coordinate multiple ...
Eibes González, Susana (Date of defense: 2016-09-13)
Mitosis is a tightly regulated process that aims to ensure the correct distribution of the chromosomes between the two newly generated cells. Many protein kinases have been defined as essential for this ...
Escobedo Pascual, Albert (Date of defense: 2014-11-06)
Nedd4L is a HECT-type E3 ubiquitin ligase (it covalently binds ubiquitin molecules before transferring them to the final substrate). Ubiquitination is a posttranslational modification (PTM) that labels ...